The Phenotype Distribution of Paraoxonase-1 in Patients with Multiple Myeloma, Bladder, and Colorectal Cancer

Elli̇dağ, Hamit Yaşar; Eren, Esin; Aydın, Özgür; Neşeli̇oğlu, Salim; Yılmaz, Necat

doi:10.2478/jomb-2014-0011

Cited by 6 publications

(8 citation statements)

References 22 publications

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“…In agreement with the present study, previous reports of Ellidag et al (2014), they determined the phenotype distribution and enzymatic activity of PON1 and ARE in CRC, bladder cancer and multiple myeloma patients as compared to healthy subjects. PON 1 and ARE activities were significantly lower in the cancer patients as compared to the control group.…”

Section: Discussionsupporting

confidence: 93%

The interplay between paraoxonase-1 and epigenetic changes in colorectal carcinoma

Kamel¹,

Hussein²,

Ibrahim³

et al. 2018

Afr. J. Biochem. Res.

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Colorectal cancer (CRC) is the third leading cause of cancer-related death. Colorectal mucosa has high levels of oxidative stress (OS) landmarks. OS has deleterious effect on cell structures as lipids, proteins and DNA. Markers of protein oxidation are named as advanced oxidation protein products (AOPPs) which have been considered as novel disease biomarkers. OS may also induce DNA damage which leads to mutation of chromosomes. Paraoxonase 1 (PON1) and Arylesterase (ARE) metabolize different substrates and act as antioxidant enzymes. Disruption of epigenetic processes can lead to altered gene function and malignant transformation. Altered expression of genes that encode histone deacetylase (HDACs) are linked to tumor development. The aim of this study was to evaluate the PON1 and ARE activities in CRC patients and to assess the epigenetic fingerprint via estimation of HDAC. The study was carried out on 30 CRC patients. After excision of tumor, segments were divided into two groups: group A (Control group) included parts taken from safety margin; Group B: (CRC group) subdivided into 3 grades, grade I: well differentiated tumor, grade II: moderately differentiated tumor, and grade III: poor differentiated tumor. CRC groups showed elevation of OS landmarks (AOPPs and DNA damage), HDACs activity and significant decrease in the level of PON1 and activities of PON1 and ARE. The histopathological results were correlated with the laboratory results. It was concluded that the damage of AOPPs and DNA is novel biomarkers in diagnosis of CRC; PON1 is important protective antioxidant enzyme and HDAC activity estimation is a promising line in CRC diagnosis.

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Section: Discussionsupporting

confidence: 93%

The interplay between paraoxonase-1 and epigenetic changes in colorectal carcinoma

Kamel¹,

Hussein²,

Ibrahim³

et al. 2018

Afr. J. Biochem. Res.

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“…The frequency of the PON1 R allele in the current study was in line with previous studies carried out on this population. Our previous study revealed that the frequency of the R allele in cancer patients was 0.28 [ 16 ]. Karakaya et al .…”

Section: Discussionmentioning

confidence: 99%

Phenotype distribution of the paraoxonase gene in patients with cardiac disease

Elli̇dağ

Aydın²,

Eren

et al. 2017

aoms

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IntroductionParaoxonase (PON1) is an enigmatic enzyme with multiple enzymatic properties including arylesterase and lactonase activities besides its ability to hydrolyze the toxic metabolite of parathion, paraoxon. The aim of this study was to determine the phenotype distribution of PON1 in patients with cardiac disease who were classified in coronary artery bypass grafting (CABG), heart valve disease (HVD), heart failure (HF) and ST elevation myocardial infarction (STEMI) groups and healthy subjects as a control group.Material and methodsA total of 300 people (100 cardiac surgery (70 CABG and 30 HVD), 70 HF, 30 STEMI patients and 100 healthy controls) were admitted to this study. Individual variations in PON1 were determined using the dual substrate (paraoxon and phenylacetate) method.ResultsThe following phenotype distributions were found in the cardiac disease and control groups: cardiac disease group (n = 200): 48.5% (QQ), 42.5% (QR), 9% (RR) and control group (n = 100): 58% (QQ), 39% (QR), 3% (RR). RR (high activity) phenotypic distribution was more common in the cardiac disease group than in controls (p = 0.04). In particular, the frequency of the RR phenotype was two- to three-fold higher in the STEMI and HF patients compared to the controls as well as CABG and HVD groups.ConclusionsWe found a higher percentage of RR phenotype in STEMI and HF patients compared to a large control group as well as compared to two other groups of cardiac disease patients.

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“…In Group II, CEA sensitivity alone was the same, the specificity of both CEA and CA 19-9 was lower and the sensitivity and specificity of the combined detection of CEA and CA 19-9 were also lower in relation to the Group I, which was the group with patients suffering from CRC in all stages of the disease ( Table II ). In addition to the widely used tumor markers CEA and CA 19-9, there is an indication of the importance of new biomarkers that might be able to improve the diagnosis of CRC ( 28 , 29 ). Studies by other authors suggest that, although elevated to a significant proportion in preclinical CRC, CEA alone is not sufficient as a screening tool.…”

Section: Discussionmentioning

confidence: 99%

Predictive Value of Carcinoembryonic and Carbohydrate Antigen 19-9 Related to Some Clinical, Endoscopic and Histological Colorectal Cancer Characteristics

Tomašević

Milosavljević

Stojanović

et al. 2016

Journal of Medical Biochemistry

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SummaryBackgroundColorectal cancer (CRC) is an important oncological and public health problem worldwide, including Serbia. Unfortunately, half of the patients are recognized in an advanced stage of the disease, therefore, early detection through specific tumor biomarkers, such as carcinoembryonic (CEA) and carbohydrate antigen 19-9 (CA 19-9), is the only way to cope with CRC expansion.MethodsOur cross-sectional study evaluated the influence of some clinical, endoscopic and histological characteristics of CRC on CEA and CA 19-9 serum levels, to determine whether these biomarkers could be related to CRC detection. The study included 372 participants: 181 suffered from CRC and 191 participants were controls. Endoscopic and histological examinations were used for CRC diagnosis, while additional ultrasound and abdominal computerised tomography imaging were used for staging the disease. Measurement of CEA and CA 19-9 was performed after CRC confirmation.ResultsAge, gender, tumor localization, macro-morphological and histological characteristics did not influence biomarkers serum levels. Both were significantly higher (p<0.01) in patients with Dukes D stage of CRC compared with controls. Sensitivity (76.8%) and specificity (76.6%) of CEA alone were higher than for CA 19-9, but with no statistical significance. Furthermore, sensitivity of CEA alone in the Dukes A/B group was similar to the entire CRC patient group.ConclusionsAlthough not recommended as a screening method for the general population, elevated values of each biomarker indicate further diagnostic procedures and their simultaneous testing can improve the diagnostic sensitivity in early detection of CRC, as shown by the united analysis (AUC 0.842).

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The Phenotype Distribution of Paraoxonase-1 in Patients with Multiple Myeloma, Bladder, and Colorectal Cancer

Cited by 6 publications

References 22 publications

The interplay between paraoxonase-1 and epigenetic changes in colorectal carcinoma

The interplay between paraoxonase-1 and epigenetic changes in colorectal carcinoma

Phenotype distribution of the paraoxonase gene in patients with cardiac disease

Predictive Value of Carcinoembryonic and Carbohydrate Antigen 19-9 Related to Some Clinical, Endoscopic and Histological Colorectal Cancer Characteristics

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