The pheromone affects reproductive physiology and behavior by regulating hormone in juvenile mice

Hu, Bing; Mo, Zhongxiang; Jiang, Jianlin; Liang, Jie; Wei, Minlin; Zhu, Xinyuan; Liang, Yuan; Huang, Qiao-Juan; Ouyang, Yanling

doi:10.1080/08977194.2022.2053527

Cited by 3 publications

(5 citation statements)

References 25 publications

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“…Pesticides that extensively used in farming act as endocrine-disrupting chemicals, and significantly affect the time of puberty onset (72). In addition, pheromones are also considered to promote hormone secretions and induce CPP (73). Collectively, keeping children from this environmental pollution helps prevent CPP and related diseases.…”

Section: Treatment and Prevention Strategies For Cppmentioning

confidence: 99%

Childhood obesity and central precocious puberty

Jiang

Zhang

2022

Front. Endocrinol.

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Childhood obesity is a major public health problem worldwide, and the relationship between obesity and central precocious puberty has long been confirmed, however, the mechanisms underlying this association remain elusive. This review provides an overview of the recent progress regarding how childhood obesity impacts on hypothalamic-pituitary-gonadal axis and pubertal onset, focusing on adipokines (leptin and ghrelin), hormone (insulin), and lipid (ceramide), as well as critical signaling pathways (AMPK/SIRT, mTOR) that integrate the peripheral metabolism and central circuits. Notably, prevention of obesity and CPP is beneficial for the adult life of the children, thus we further summarize the potential strategies in treating and preventing childhood obesity and CPP. The updated understanding of metabolic stress and pediatric endocrine disease will arise the attention of society, and also contribute to preventing more serious comorbidities in the later period of life in children.

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Section: Treatment and Prevention Strategies For Cppmentioning

confidence: 99%

Childhood obesity and central precocious puberty

Jiang

Zhang

2022

Front. Endocrinol.

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“…Pheromones play a major role in reproduction in mammals [ 7 , 9 , 13 ]; however, a few studies have demonstrated pheromone synthesis molecular pathways and their specified role in reproduction. In this study, two odorous 16-androstenes (androstenone and androstenol) were identified in mouse deer which showed that the mouse deer P450C17 gene possesses an andien-β-synthase activity to transform pregnenolone to 5,16-androstadien-3β-ol, although the 5,16-androstadien-3β-ol is considered to be an intermediate and precursor in the 16 androstene pathway leading to the biosynthesis of androstenone and androstenol [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

“…In mammals, pheromones play various important roles in distantly related species, such as in social interactions and organization [ 2 ], sexual attraction [ 3 ], communication between mother and offspring [ 4 ], dominance and aggregation behavior [ 5 ], and scent marking and territorial behavior [ 6 ]. Pheromones are known to influence the secretion of gonadotropin hormones, testosterone, and luteinizing hormones in mice [ 7 ], sea lampreys [ 8 ], and sows [ 9 ]. A significant relationship between pheromones and reproductive hormones in pigs [ 10 ] and Asian elephants [ 11 ] was observed.…”

Section: Introductionmentioning

confidence: 99%

Discovery of 16-Androstenes (Androstenone and Androstenol), Their Synthesis Pathway, and Possible Role in Reproduction of Mouse Deer (Moschiola indica)

Kumar

Manu

Caroline

et al. 2022

Cells

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We discovered odorous 16-androstenes (Androstenone and Androstenol) in endangered mouse deer during a captive breeding program. This study examined the molecular characteristics, their synthesis pathway, and the possible functional role of these compounds in the reproduction of mouse deer. CYP17A1 and CYB5 genes were cloned and expressed in HEK-293, COS-7 cell lines, and gonads of mouse deer to investigate the CYP17A1 gene’s andien-β-synthase activity towards the synthesis of 16-androstenes in mouse deer. An enzyme immunoassay was further developed and standardized to measure fecal androstenone during the reproductive cycles of mouse deer. Results showed that the mouse deer CYP17A1 gene possesses andien-β-synthase activity and could transform pregnenolone into 5,16-androstadien-3β-ol. The expression of the CYP17A1 gene upregulated in the testis and ovary compared to other tissues in mouse deer. Significantly elevated androstenone and estrogens were recorded prior to delivery and postpartum estrus/mating in mouse deer. Further, there were weak correlations between fecal androstenone and estrogens/androgens in mouse deer during the breeding season. These findings suggest that androstenone probably plays a role in the reproductive activities of mouse deer. This knowledge can be used for captive breeding programs of mouse deer in India and elsewhere.

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“…Pheromones play major role in reproduction in mammals (13,7,9), however, a few studies have demonstrated the pheromone synthesis molecular pathways and their specified role in reproduction. In this study, two putative sex pheromones (androstenone and androstenol) which we identified in mouse deer showed that mouse deer P450C17 gene possess an andien-β-synthase activity to transform pregnenolone to 5,16-androstadien-3β-ol, Although he 5,16-androstadien-3β-ol is considered to be an intermediate and precursor in the 16 androstene pathway leading to the biosynthesis of androstenone and androstenol (34).…”

Section: Discussionmentioning

confidence: 99%

“…In mammals, the pheromone plays various important roles in distantly related species such as in social interactions and organization (2), sexual attraction (3), communication between mother and offspring (4), dominance and aggregation behaviour (5), scent marking and territorial behaviour (6). Pheromones are known to influence the secretion of gonadotropin hormones, testosterone, and luteinizing hormones in mice (7), Sea lampreys (8), and sows (9). A significant relationship between pheromones and reproductive hormones in pigs (10) and Asian elephants (11) was observed.…”

Section: Introductionmentioning

confidence: 99%

Discovery of Boar Pheromones and their Functional Role in Reproduction of Mouse Deer (<em>Moschiola Indica</em>)

Kumar¹,

Manu²,

Caroline³

et al. 2022

Preprint

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Two putative boar pheromones (Androstenone and Androstenol) were discovered in endangered mouse deer during captive breeding program. This study further examined the molecular characteristics, pheromone synthesis pathway, and the functional role of these pheromones in reproduction of mouse deer. CYP17A1 and CYB5 genes were cloned and expressed in HEK-293, COS-7 cell lines and gonads of mouse deer to investigate CYP17A1 gene’s andien-β-synthase activity towards synthesis of sex pheromones in mouse deer. An enzyme immunoassay was also developed and standardized to measure the fecal androstenone during reproductive cycles of mouse deer. Results showed that mouse deer’s CYP17A1 gene possesses andien-β-synthase activity and could transform pregnenolone into 5,16-androstadien-3β-ol. The expression of CYP17A1 gene upregulated in the testis and ovary, compared to other tissues in mouse deer. Significantly elevated pheromones and estrogens were recorded prior to delivery and postpartum estrus / mating in mouse deer. Further, there were weak correlations between fecal pheromones and estrogens/ androgens in mouse deer during breeding season. The findings suggest that the boar pheromones might play a direct role in the reproductive activities of mouse deer which might be used for breeding of mouse deer elsewhere.

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The pheromone affects reproductive physiology and behavior by regulating hormone in juvenile mice

Cited by 3 publications

References 25 publications

Childhood obesity and central precocious puberty

Childhood obesity and central precocious puberty

Discovery of 16-Androstenes (Androstenone and Androstenol), Their Synthesis Pathway, and Possible Role in Reproduction of Mouse Deer (Moschiola indica)

Discovery of Boar Pheromones and their Functional Role in Reproduction of Mouse Deer (<em>Moschiola Indica</em>)

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