2016
DOI: 10.1038/mp.2016.174
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The PHF21B gene is associated with major depression and modulates the stress response

Abstract: Major depressive disorder (MDD) affects around 350 million people worldwide, however the underlying genetic basis remains largely unknown. In this study, we took into account that MDD is a gene-environment disorder in which stress is a critical component, and used whole genome screening of functional variants to investigate the ‘missing heritability’ in MDD. GWAS analyses using single- and multi-locus linear mixed-effect models were performed in a Los Angeles Mexican-American cohort (196 controls, 203 MDD) and… Show more

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Cited by 59 publications
(49 citation statements)
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References 76 publications
(92 reference statements)
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“…PHF2 was recently detected as genome-wide significant at the latest meta-analysis of depression 80 . Notably, PHF2 paralogs have already been link with MDD through stress-response in three other studies 91-93 . Joint effects in GS also detected an additional significant association upstream CYLC2 , a gene nominally associated (p < 1×10’ 5 ) with obsessive-compulsive disorder and Tourette’s Syndrome 94 .…”
Section: Discussionmentioning
confidence: 96%
“…PHF2 was recently detected as genome-wide significant at the latest meta-analysis of depression 80 . Notably, PHF2 paralogs have already been link with MDD through stress-response in three other studies 91-93 . Joint effects in GS also detected an additional significant association upstream CYLC2 , a gene nominally associated (p < 1×10’ 5 ) with obsessive-compulsive disorder and Tourette’s Syndrome 94 .…”
Section: Discussionmentioning
confidence: 96%
“…We did not detect significantly differentially methylated loci associated with exclusive cannabis use at the epigenome-wide level. However, an assessment of those top loci reaching nominal significance (P<0.05) identified CpG sites within genes involved in brain function and mood disorders, including MUC3L 81; 82 , CDC20 83 , DUS3L 84 TMEM190 85 , FOXB1 8688 , KIAA1324L/GRM3 82; 89–94 , DDX25 81; 95; 96 TNRC6B 97; 98 and SP9 99 .…”
Section: Discussionmentioning
confidence: 99%
“…In our recent work (Wong et al, 2016) we have investigated whole-exome genotyping of a Los Angeles Mexican-American cohort of 203 MDD patients and 196 healthy controls, aged 19–65 years. Participants in this cohort had three or more grandparents born in Mexico.…”
Section: Methodsmentioning
confidence: 99%
“…We performed the variant calling analysis of high quality paired-end sequencing reads using a previously described pipeline (Wong et al, 2016). Briefly, we aligned the reads of each participant to the human reference genome (hg19, Genome Reference Consortium GRCh37) using Burrows-Wheeler Aligner (Li and Durbin, 2009) to get SAM (sequence alignment/map) format files.…”
Section: Methodsmentioning
confidence: 99%