The Philadelphia Pulmonary Neoplasm Research Project

Weiss, William A.; Boucot, Katharine R.

doi:10.1001/archinte.1974.00320200116016

Cited by 43 publications

(3 citation statements)

References 19 publications

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“…Squamous cell carcinomas generally grow more slowly and less often give rise to distant metastases than do small cell carcinomas, which metastasize early and widely. Adenocarcinomas tend to grow slowly but have a high metastatic potential (46). Increases in the relative frequencies of squamous cell carcinoma (47) and adenocarcinoma (19,48,49) have been reported.…”

Section: Manual Of Tumor Nomenclature and Coding (Motnac) (1951) 12mentioning

confidence: 99%

Environmental Associations and Histopathologic Patterns of Carcinoma of the Lung: The Challenge and Dilemma in Epidemiologic Studies

Ives¹,

Buffler²,

Greenberg³

1983

Am Rev Respir Dis

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An update of histopathologic classification schemes is provided for carcinoma of the lung and factors that influence proportional distributions of cell types, i.e., sources and preparations of tissue specimens, observer variability, and use of secondary sources of information. Consideration is given to the natural history and to current knowledge of the demographic characteristics of cell types of carcinoma of the lung. A review of studies reporting histopathologic associations with environmental exposures suggests that no single type of carcinoma of the lung is specifically associated with exposure to tobacco smoke, arsenic, or beryllium. Furthermore, studies concerned with exposure to asbestos, chloroethers, chromates, nickel, vinyl chloride, and radioactivity lack sufficient information to conclude definitively that only one specific lung cancer cell type is associated with these exposures. In conclusion, an exclusive association of a single cell type of carcinoma of the lung with exposure to the physical or chemical agents reviewed has not been demonstrated.

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Section: Manual Of Tumor Nomenclature and Coding (Motnac) (1951) 12mentioning

confidence: 99%

Environmental Associations and Histopathologic Patterns of Carcinoma of the Lung: The Challenge and Dilemma in Epidemiologic Studies

Ives¹,

Buffler²,

Greenberg³

1983

Am Rev Respir Dis

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“…Data is available from the Philadelphia project and the early lung cancer detection programs which sequentially followed at-risk groups of individuals who were heavy smokers and over 45 years of age. In these studies the incidence of lung cancer was 121/6136 (20ro) [18] and 34/6612 (0.5%) [19]. In comparison, for the treated lymphoma patients 5/83 (6010) older than 45 years and followed more than 4 years developed lung cancer.…”

Section: Disc Usslonmentioning

confidence: 88%

Lung cancer as a complication of prolonged survival in patients with lymphoma

Konits

Aisner

Whitacre

et al. 1982

Med. Pediatr. Oncol.

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As a result of successful therapy with radiation, chemotherapy, or both, patients with lymphoma are living longer. The improved survival has led to an increased awareness of long term complications including second or subsequent malignancies. We have recently seen six cases of lung cancer--three adenocarcinomas, one squamous cell carcinoma, and two small cell carcinomas--among 655 patients with Hodgkin and non-Hodgkin lymphoma suggesting a possible association, although other carcinogenic or cocarcinogenic factors cannot be eliminated.

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“…The first studies evaluating screening for lung cancer utilised chest X-ray and/or sputum cytology [6–9]. While these showed increased numbers of earlier-stage, resectable cancers and improved survival rates in the screened groups, not all studies were randomised.…”

Section: Introductionmentioning

confidence: 99%

Detection in blood of autoantibodies to tumour antigens as a case-finding method in lung cancer using the EarlyCDT®-Lung Test (ECLS): study protocol for a randomized controlled trial

et al. 2017

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BackgroundLung cancer is the most common cause of cancer related death worldwide. The majority of cases are detected at a late stage when prognosis is poor. The EarlyCDT®-Lung Test detects autoantibodies to abnormal cell surface proteins in the earliest stages of the disease which may allow tumour detection at an earlier stage thus altering prognosis.The primary research question is: Does using the EarlyCDT®-Lung Test to identify those at high risk of lung cancer, followed by X-ray and computed tomography (CT) scanning, reduce the incidence of patients with late-stage lung cancer (III & IV) or unclassified presentation (U) at diagnosis, compared to standard practice?MethodsA randomised controlled trial of 12 000 participants in areas of Scotland targeting general practices serving patients in the most deprived quintile of the Scottish Index of Multiple Deprivation. Adults aged 50–75 who are at high risk of lung cancer and healthy enough to undergo potentially curative therapy (Performance Status 0–2) are eligible to participate. The intervention is the EarlyCDT®-Lung Test, followed by X-ray and CT in those with a positive result. The comparator is standard clinical practice in the UK. The primary outcome is the difference, after 24 months, between the rates of patients with stage III, IV or unclassified lung cancer at diagnosis. The secondary outcomes include: all-cause mortality; disease specific mortality; a range of morbidity outcomes; cost-effectiveness and measures examining the psychological and behavioural consequences of screening.Participants with a positive test result but for whom the CT scan does not lead to a lung cancer diagnosis will be offered 6 monthly thoracic CTs for 24 months. An initial chest X-ray will be used to determine the speed and the need for contrast in the first screening CT. Participants who are found to have lung cancer will be followed-up to assess both time to diagnosis and stage of disease at diagnosis.DiscussionThe study will determine the clinical and cost effectiveness of EarlyCDT®-Lung Test for early lung cancer detection and assess its suitability for a large-scale, accredited screening service. The study will also assess the potential psychological and behavioural harms arising from false positive or false negative results, as well as the potential benefits to patients of true negative EarlyCDT lung test results. A cost-effectiveness model of lung cancer screening based on the results of the EarlyCDT Lung Test study will be developed.Trial registration NCT01925625. August 19, 2013Electronic supplementary materialThe online version of this article (doi:10.1186/s12885-017-3175-y) contains supplementary material, which is available to authorized users.

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The Philadelphia Pulmonary Neoplasm Research Project

Cited by 43 publications

References 19 publications

Environmental Associations and Histopathologic Patterns of Carcinoma of the Lung: The Challenge and Dilemma in Epidemiologic Studies

Environmental Associations and Histopathologic Patterns of Carcinoma of the Lung: The Challenge and Dilemma in Epidemiologic Studies

Lung cancer as a complication of prolonged survival in patients with lymphoma

Detection in blood of autoantibodies to tumour antigens as a case-finding method in lung cancer using the EarlyCDT®-Lung Test (ECLS): study protocol for a randomized controlled trial

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