The Phospholipids of Normal and Thalassaemic Erythrocytes

Haemolysis and Erythrocyte Lipids in Thalassaemia Major

“…An analysis of the phospholipid fractions reveals a highly significant increase of sphingomyelin and phosphatidylcholine, matched by a highly significant decrease of phosphatidylethanolamine and phosphatidylserine. These findings are in agreement with those of Nicolopoulos et al [17], who used methods similar to ours and showed an increase of sphingomyelin and phosphatidylcholine. An increase of sphin- gomyelin and a slight decrease of phosphatidylethanolamine were also pointed out by M ussini et al [15].…”

“…In this disease, the red cell lipids have been studied [1,4,15,17,20] while, to our knowledge, no studies concerning the fatty acid composition of erythrocyte phospholipid fractions have been pub lished, but only some studies pertaining to the total erythrocyte fatty acids [2,9,10,18,19], Therefore, we have studied the red cell lipids and the fatty acid com position of phospholipid fractions in 20 patients with /Mhalassaemia as compared to healthy subjects of the same age.…”

Λιπιδιακη Διερευνησις Των Ερυθροκυτταρων Εις Την Ετεροζυγον Β - Μεσο- Γειακων Αναιμιαν

“…Τό ως άνω εύρημα συμφωνεί μέ τά ευρήματα άλλων ερευνητών προ κειμένου διά τήν όμόζυγον β-Μεσ. άναιμίαν (Nicolopoulos 1966 καί συν. 1974) ή οποία στερεί τό έσωτερικόν του ερυθροκυττάρου άπό Κ τά όποια ενεργοποιούν εις τό μέγιστο τήν πυροσταφυλική κινάση (Lehninger 1971) ϊδε σχήμα 7.…”