2019
DOI: 10.1007/s10103-019-02725-4
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The photocytotoxicity effect of cationic sulfonated corrole towards lung cancer cells: in vitro and in vivo study

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Cited by 6 publications
(5 citation statements)
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“…In general, the cationic structure is widely used for antimicrobial PDT due to the promotion of electrostatic interaction between positively charged photosensitizer and negatively charged bacterial cell wall [55,56] . Several studies also have shown that positive electric charge is able to promote the PDT effects in cancer therapy [57–59] . However, it was also found that the photodynamic effect may decrease gradually with the increase in the number of positive charges .…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…In general, the cationic structure is widely used for antimicrobial PDT due to the promotion of electrostatic interaction between positively charged photosensitizer and negatively charged bacterial cell wall [55,56] . Several studies also have shown that positive electric charge is able to promote the PDT effects in cancer therapy [57–59] . However, it was also found that the photodynamic effect may decrease gradually with the increase in the number of positive charges .…”
Section: Resultsmentioning
confidence: 99%
“…[55,56] Several studies also have shown that positive electric charge is able to promote the PDT effects in cancer therapy. [57][58][59] However, it was also found that the photodynamic effect may decrease gradually with the increase in the number of positive charges . [60] Thus, the amount of positive electric charges of the photosensitizer should be carefully optimized.…”
Section: Singlet Oxygen Generation Measurementsmentioning
confidence: 99%
“…Water-soluble sodium salts of sulfonated corrole 98 and its metal complexes of copper ( 99 - Cu ), iron ( 99 - Fe ) and manganese ( 99 - Mn ) were prepared and their photodynamic anti-cancer activity against human tumor cell lines, namely lung carcinoma (A549), hepatocellular cancer (HepG2) and cervical cancer (HeLa), was evaluated ( Figure 3 ) [ 79 ]. Photocytotoxicity studies demonstrated that all the tested cell lines are sensitive to the presence of corrole 98 , especially A549 cells (IC 50 = 5.0 μM), while no dark toxicity was observed with the studied corroles.…”
Section: Corroles As Pdt Agents In Cancer Treatmentmentioning
confidence: 99%
“…Previously, metalated corroles demonstrated increased cytotoxicity towards various cells based on the metal present in the corrole core. 20,27,28…”
Section: Resultsmentioning
confidence: 99%