The Physiological Role of Glucagon in the Gastrointestinal Tract

Wingate, David; Pearce, Elizabeth

doi:10.1007/978-94-009-9212-2_3

Cited by 6 publications

(2 citation statements)

References 34 publications

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“…Wingate and his colleagues (Wingate, Morris & Thomas, 1977;Wingate & Pearce, 1979) studying electrical activity in the duodenum and jejunum of the conscious fasted dog, described an apparent discrepancy between glucagon given as an intravenous bolus and an infusion. Whilst a bolus dose of 1 mg of glucagon caused apparent inhibition of fast spiking electrical activity, an infusion of 0.5, 0.25 and 0.125 mgh caused a significant increase in spiking activity.…”

Section: Introduction Methodsmentioning

confidence: 99%

“…This action on smooth muscle has been used to clinical advantage during hypotonic duodenography (Chernish & Miller, 1972) and barium enema examination (Gohel, Dalinka & Goren, 1974) and has led to improved visualization during endoscopic retrograde pancreatography (Hradsky, Stockbrugger & Dotevall, 1974). Wingate and his colleagues (Wingate, Morris & Thomas, 1977;Wingate & Pearce, 1979) studying electrical activity in the duodenum and jejunum of the conscious fasted dog, described an apparent discrepancy between glucagon given as an intravenous bolus and an infusion. Whilst a bolus dose of 1 mg of glucagon caused apparent inhibition of fast spiking electrical activity, an infusion of 0.5, 0.25 and 0.125 mgh caused a significant increase in spiking activity.…”

Section: Introduction Methodsmentioning

confidence: 99%

See 1 more Smart Citation

The Action of Porcine Glucagon on the Motility of the Canine Duodenum and Jejunum

Evans

Foster

Hardcastle

et al. 1982

British J Pharmacology

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Intravenous bolus doses of porcine glucagon of 0.001 −0.05 mg kg−1 caused intense stimulation of the duodenum and jejunum of the dog. Intravenous infusion of porcine glucagon at 0.025 −0.05 mg kg−1 h−1 caused similar stimulation. In both cases the stimulation was phasic in nature. Stimulation of the duodenum and jejunum following glucagon was accompanied by a decrease in frequency of the intestinal basic electrical rhythm (BER). No change was seen in the intervals between successive periods of phase III motor activity.

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Section: Introduction Methodsmentioning

confidence: 99%