The physiology of waterborne silver toxicity in freshwater rainbow trout (Oncorhynchus mykiss) 1. The effects of ionic Ag+

Wood, Chris M.; Högstrand, Christer; Gálvez, Fernando; Munger, R. Stephen

doi:10.1016/0166-445x(96)00003-3

Cited by 200 publications

(210 citation statements)

References 37 publications

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“…According to the BLM concept, ions compete with each other for transport sites at the biotic ligands, and this competition acts as a mechanism for ion-ion interactions [1,2]. This assumption is based on physiological findings indicating that toxic cations, such as Cu 2þ and Ag þ , may inhibit the uptake of Na þ or Ca 2þ for specific binding sites at the fish gill, leading to adverse effects [3][4][5]. Furthermore, the assumption potentially allows taking into account interactions between different metal ions in assessment of mixture toxicity [1,6,7].…”

Section: Introductionmentioning

confidence: 99%

Modeling toxicity of binary metal mixtures (Cu2+–Ag+, Cu2+–Zn2+) to lettuce, Lactuca sativa, with the biotic ligand model

Vijver

Hendriks

et al. 2012

Environmental Toxicology and Chemistry

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Abstract-The biotic ligand model (BLM) was applied to predict metal toxicity to lettuce, Lactuca sativa. Cu 2þ had the lowest median effective activity (EA50 M ), compared with Ag þ and Zn 2þ (EA50 Cu ¼ 2.60 Â 10 À8 M, EA50 Ag ¼ 1.34 Â 10 À7 M, EA50 Zn ¼ 1.06 Â 10 À4 M). At the 50% response level, the fraction of the total number of biotic ligands occupied by ions ( f50 M ) was lowest for Ag þ among the metals ( f50 Ag ¼ 0.22, f50 Cu ¼ 0.36, f50 Zn ¼ 0.42). Cu 2þ had the highest affinity for biotic ligands compared with Ag þ and Zn 2þ , as shown by stability constants of the cation-biotic ligand binding, expressed as log K MBL (log K CuBL ¼ 7.40, log K AgBL ¼ 6.39, log K ZnBL ¼ 4.00). Furthermore, the BLM was combined with the toxic equivalency factor approach in predicting toxicity of mixtures of Cu 2þ -Zn 2þ and Cu 2þ -Ag þ . The fraction of biotic ligands occupied by ions was used to determine the relative toxic potency of metals and the toxic equivalency quotient (TEQ) of mixtures. This approach allowed for including interactions in estimating mixture toxicity and showed good predictive power (r 2 ¼ 0.64-0.84). The TEQ at the 50% response level (TEQ50, Cu 2þ equivalents) for Cu 2þ -Zn 2þ mixtures was significantly lower than the value for Cu 2þ -Ag þ mixtures. Joint toxicity depended on both TEQ and specific composition of the mixture. The present study supports the use of the accumulation of metal ions at the biotic ligands as a predictor of toxicity of single metals and mixtures. Environ. Toxicol. Chem. 2013;32:137-143. # 2012 SETAC

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Section: Introductionmentioning

confidence: 99%

Modeling toxicity of binary metal mixtures (Cu2+–Ag+, Cu2+–Zn2+) to lettuce, Lactuca sativa, with the biotic ligand model

Vijver

Hendriks

et al. 2012

Environmental Toxicology and Chemistry

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“…Silver toxicity and the pathological effects of waterborne silver are well known in freshwater fish species (Janes and Playle 1995;Wood et al 1996;Zhou et al 2005). The gill is considered the main route for waterborne Ag uptake and destruction of tissue by reaching the branchial epithelial cells via the Na ?…”

Section: Introductionmentioning

confidence: 99%

Histopathological effects of waterborne silver nanoparticles and silver salt on the gills and liver of goldfish Carassius auratus

Abarghoei

Hedayati

Ghorbani

et al. 2016

Int. J. Environ. Sci. Technol.

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This study aimed to compare histopathological effect of waterborne silver nanoparticles and silver salt (AgNO 3 ) on the gills and liver of Carassius auratus. Therefore, one hundred and five live specimens of goldfish were obtained and treated in five aquariums with 0, 0.01, 0.025, 0.05, and 0.1 ppm of AgNO 3 and 0, 0.1, 0.5, 1, and 5 ppm of Ag nanoparticles (mean particle size of 5 nm). Fish were sampled after 14 days of exposure. Results showed that the kinds of pathologies observed with Ag NPs were broadly of the same type as AgNO 3 including hyperplasia, edema and lifting of the gill epithelium, and lamellar fusion of the gills, and hemosiderosis, hemorrhage, hydropic swelling, and pyknotic nuclei of the liver. Overall, the data showed that although Ag nanoparticles and AgNO 3 pathology were similar, but Ag nanoparticles caused less injury than AgNO 3 in the gills and liver of goldfish. Therefore, it is more proper to use nanoform of Ag in industrials.

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“…This may be due to the short exposure time (3 h) because the inhibition of Na influx was related to the exposure time. In rainbow trout, AgNO 3 exposure initially decreased the Na influx by nearly 40% (0-to 4-h exposure) and finally by 99% (46-to 50-h exposure), which was much more obvious than that of daphnids [27]. It appeared that such an effect on Na influx could only be observed under waterborne Ag exposure.…”

Section: Na Influx and Effluxmentioning

confidence: 92%

“…However, in the present study, the highest reduction of Na body burden under AgNO 3 and AgNP exposures was 11.0 to 13.6% after 2 d of exposure. Wood et al [27] also found that Na influx was inhibited dramatically in 24 h, but Na content in the plasma of rainbow trout was not significantly reduced. This indicated that some other mechanisms on Na compensation may be activated.…”

Section: Na Influx and Effluxmentioning

confidence: 95%

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Regulation of sodium and calcium in Daphnia magna exposed to silver nanoparticles

Zhao

Wang

2013

Environmental Toxicology and Chemistry

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Abstract-The toxicity of manufactured silver nanoparticles (AgNPs) has been widely studied, but the influence of AgNPs on the major ions (such as sodium [Na] and calcium [Ca]) regulations are unknown. In the present study, a freshwater cladoceran Daphnia magna was exposed to commercial AgNPs coated with polyvinylpyrrolidone. After 48 h, the Na body content was significantly reduced by AgNO 3 exposure, but the Ca body content was significantly increased under AgNO 3 and AgNP exposures, respectively. No effect was observed on the body concentrations of Na and Ca at 50 to 500 mg/L AgNPs with 1-mM cysteine addition. Exposure of AgNO 3 and AgNPs inhibited the Na influx and elevated the Na efflux. In contrast, their exposure increased the Ca influx, but did not affect the Ca efflux. The results of the present study demonstrated the significant influences of AgNO 3 and AgNPs (without cysteine) on Na and Ca regulations. Such effect of AgNPs on Na and Ca regulation disappeared after cysteine addition, indicating that the soluble Ag released from AgNPs played a major role in the ionoregulatory dysfunction. Environ. Toxicol. Chem. 2013;32:913-919. # 2013 SETAC

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The physiology of waterborne silver toxicity in freshwater rainbow trout (Oncorhynchus mykiss) 1. The effects of ionic Ag+

Cited by 200 publications

References 37 publications

Modeling toxicity of binary metal mixtures (Cu2+–Ag+, Cu2+–Zn2+) to lettuce, Lactuca sativa, with the biotic ligand model

Modeling toxicity of binary metal mixtures (Cu2+–Ag+, Cu2+–Zn2+) to lettuce, Lactuca sativa, with the biotic ligand model

Histopathological effects of waterborne silver nanoparticles and silver salt on the gills and liver of goldfish Carassius auratus

Regulation of sodium and calcium in Daphnia magna exposed to silver nanoparticles

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