The phytoactive constituents of Eugenia selloi B.D. Jacks (pitangatuba): Toxicity and elucidation of their anti-inflammatory mechanism(s) of action

Lazarini, Josy Goldoni; Massarioli, Adna Prado; Soares, Jackeline Cintra; Nani, Bruno Dias; Charó, Nancy L.; Oliveira, Denise Silva de; Camargo, Luiz Octávio de Lima; Alvarez-Flores, Miryam Paola; Batista, Isabel de Fátima Correia; Chudzinski-Tavassi, Ana Marisa; Alencar, Severino Matias de; Franchin, Marcelo; Rosalen, Pedro Luiz

doi:10.1016/j.fochms.2022.100093

Food Chemistry: Molecular Sciences

2022

DOI: 10.1016/j.fochms.2022.100093

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The phytoactive constituents of Eugenia selloi B.D. Jacks (pitangatuba): Toxicity and elucidation of their anti-inflammatory mechanism(s) of action

Josy Goldoni Lazarini

Adna Prado Massarioli

Jackeline Cintra Soares

et al.

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Cited by 4 publications

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Pathogenesis‐Guided Engineering: pH‐Responsive Imprinted Polymer Co‐Delivering Folate for Inflammation‐Resolving as Immunotherapy in Implant‐Related Infections

Costa,

Nagay,

Villa

et al. 2024

Adv Funct Materials

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Folate (FT) is a suitable targeting ligand for folate receptors (FOLR) overexpressed on inflamed cells. Thus, FT‐loaded polymers can be used as FOLRs‐targeted immunotherapy to positively modulate the inflammatory process. A novel biodegradable imprinted polymer with a FT delivery mechanism driven by pH changes [PCL‐MIP@FT] is designed with molecularly imprinted technology. The pH mechanism is validated in vitro, demonstrating that an acidic environment accelerated and increased the release of FT for a period of 7 days (∼100 µg mL−1). For the first time, FT receptors (FOLR‐1 and FOLR‐3) are discovered and also overexpressed on activated human gingival fibroblasts, representing a favorable target in the oral environment. Although FT itself does not have antimicrobial effects, the nanomechanical properties of biofilm are changed after topical FT administration. In vivo systemic toxicity of PCL‐MIP@FT has been demonstrated to be a safe biomaterial (up to 1.3 mg kg−1). When the PCL‐MIP@FT is assessed in the subcutaneous tissue, it promoted an alleviating inflammation and may be able to stimulate tissue repair. The present findings have demonstrated the reliable in vitro and in vivo anti‐inflammatory actions of FT‐loaded polymer and support its use as a novel drug‐free therapeutic platform for modulating and mitigating inflammatory responses in dental implant‐related infections.

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Pathogenesis‐Guided Engineering: pH‐Responsive Imprinted Polymer Co‐Delivering Folate for Inflammation‐Resolving as Immunotherapy in Implant‐Related Infections

Costa,

Nagay,

Villa

et al. 2024

Adv Funct Materials

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show abstract

Progress and promise of alternative animal and non-animal methods in biomedical research

et al. 2023

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Changes in phenolic profile and anti-inflammatory activity of Baccharis beebread during gastrointestinal digestion/intestinal permeability in vitro

Giovanini de Oliveira Sartori,

Martelli Chaib Saliba,

Sêneda Martarello

et al. 2024

Food Chemistry

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The phytoactive constituents of Eugenia selloi B.D. Jacks (pitangatuba): Toxicity and elucidation of their anti-inflammatory mechanism(s) of action

Cited by 4 publications

References 37 publications

Pathogenesis‐Guided Engineering: pH‐Responsive Imprinted Polymer Co‐Delivering Folate for Inflammation‐Resolving as Immunotherapy in Implant‐Related Infections

Pathogenesis‐Guided Engineering: pH‐Responsive Imprinted Polymer Co‐Delivering Folate for Inflammation‐Resolving as Immunotherapy in Implant‐Related Infections

Progress and promise of alternative animal and non-animal methods in biomedical research

Changes in phenolic profile and anti-inflammatory activity of Baccharis beebread during gastrointestinal digestion/intestinal permeability in vitro

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