The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation

Cao, Huojun; Jheon, Andrew H.; Li, Xiao; Sun, Zhao; Wang, Jianbo; Florez, Sergio; Zhang, Zichao; McManus, Michael T.; Klein, Ophir D.; Amendt, Brad A.

doi:10.1242/dev.089193

Cited by 99 publications

(117 citation statements)

References 65 publications

(96 reference statements)

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“…Pitx homeodomain proteins have been shown to bind a mouse Bmp4 tooth enhancer, with this binding site required for Bmp4 enhancer activity (Jumlongras et al, 2012). Pitx2 has also been shown to inhibit the BMP antagonists Bmper and Nog through miR200c in dental epithelium in mice (Cao et al, 2013) and to regulate the Wnt signaling pathway (Vadlamudi et al, 2005). Msxe, on chromosome 17, is a downstream effector of BMP signaling, and mutations in the mammalian ortholog, Msx1, cause tooth agenesis in mice (Satokata and Maas, 1994) and humans (Nieminen, 2009;Vastardis et al, 1996).…”

Section: Distinct Genetic Bases Underlie Convergently Evolved Tooth Gainmentioning

confidence: 99%

Distinct developmental and genetic mechanisms underlie convergently evolved tooth gain in sticklebacks

et al. 2015

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Teeth are a classic model system of organogenesis, as repeated and reciprocal epithelial and mesenchymal interactions pattern placode formation and outgrowth. Less is known about the developmental and genetic bases of tooth formation and replacement in polyphyodonts, which are vertebrates with continual tooth replacement. Here, we leverage natural variation in the threespine stickleback fish Gasterosteus aculeatus to investigate the genetic basis of tooth development and replacement. We find that two derived freshwater stickleback populations have both convergently evolved more ventral pharyngeal teeth through heritable genetic changes. In both populations, evolved tooth gain manifests late in development. Using pulse-chase vital dye labeling to mark newly forming teeth in adult fish, we find that both high-toothed freshwater populations have accelerated tooth replacement rates relative to lowtoothed ancestral marine fish. Despite the similar evolved phenotype of more teeth and an accelerated adult replacement rate, the timing of tooth number divergence and the spatial patterns of newly formed adult teeth are different in the two populations, suggesting distinct developmental mechanisms. Using genome-wide linkage mapping in marine-freshwater F2 genetic crosses, we find that the genetic basis of evolved tooth gain in the two freshwater populations is largely distinct. Together, our results support a model whereby increased tooth number and an accelerated tooth replacement rate have evolved convergently in two independently derived freshwater stickleback populations using largely distinct developmental and genetic mechanisms.

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Section: Distinct Genetic Bases Underlie Convergently Evolved Tooth Gainmentioning

confidence: 99%

Distinct developmental and genetic mechanisms underlie convergently evolved tooth gain in sticklebacks

et al. 2015

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“…sfrp5 has been described as a Wnt inhibitor in several systems (27,28), an integrator of Wnt-BMP signaling in the zebrafish gut (29), and a regulator of mouse incisor renewal (30). bmper has been reported as both a positive and negative mediator of BMP signaling in other organs of the mouse, frog, and fly (31)(32)(33), and as an antagonist of BMP in mouse incisor ameloblasts (34). We assayed expression of these candidates in species with divergent densities of teeth/taste buds: C. afra, a species with few teeth and taste buds and Labeotropheus fueleborni, a species with many of both (SI Appendix, Fig.…”

Section: Cichlid Tooth and Taste Bud Fields Are Specified From A Commonmentioning

confidence: 99%

Coevolutionary patterning of teeth and taste buds

Bloomquist

Parnell

Phillips

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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Teeth and taste buds are iteratively patterned structures that line the oro-pharynx of vertebrates. Biologists do not fully understand how teeth and taste buds develop from undifferentiated epithelium or how variation in organ density is regulated. These organs are typically studied independently because of their separate anatomical location in mammals: teeth on the jaw margin and taste buds on the tongue. However, in many aquatic animals like bony fishes, teeth and taste buds are colocalized one next to the other. Using genetic mapping in cichlid fishes, we identified shared loci controlling a positive correlation between tooth and taste bud densities. Genome intervals contained candidate genes expressed in tooth and taste bud fields. sfrp5 and bmper, notable for roles in Wingless (Wnt) and bone morphogenetic protein (BMP) signaling, were differentially expressed across cichlid species with divergent tooth and taste bud density, and were expressed in the development of both organs in mice. Synexpression analysis and chemical manipulation of Wnt, BMP, and Hedgehog (Hh) pathways suggest that a common cichlid oral lamina is competent to form teeth or taste buds. Wnt signaling couples tooth and taste bud density and BMP and Hh mediate distinct organ identity. Synthesizing data from fish and mouse, we suggest that the Wnt-BMP-Hh regulatory hierarchy that configures teeth and taste buds on mammalian jaws and tongues may be an evolutionary remnant inherited from ancestors wherein these organs were copatterned from common epithelium.quantitative trait loci | tooth/taste bud development | placode patterning | bipotency | plasticity

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“…The miR-200 family is comprised of five members, miR- 429-200a-200b in one cluster and miR200c-141 in another cluster located on different chromosomes. We recently reported a Pitx2:miR-200c/141:Noggin pathway regulated Bmp signaling and epithelial cell differentiation during odontogenesis (31). Thus, Pitx2 and miR-200 appear to control the fate of dental stem cells.…”

mentioning

confidence: 97%

A Pituitary Homeobox 2 (Pitx2):microRNA-200a-3p:β-catenin Pathway Converts Mesenchymal Cells to Amelogenin-expressing Dental Epithelial Cells

Sharp

Wang

et al. 2014

Journal of Biological Chemistry

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The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation

Cited by 99 publications

References 65 publications

Distinct developmental and genetic mechanisms underlie convergently evolved tooth gain in sticklebacks

Distinct developmental and genetic mechanisms underlie convergently evolved tooth gain in sticklebacks

Coevolutionary patterning of teeth and taste buds

A Pituitary Homeobox 2 (Pitx2):microRNA-200a-3p:β-catenin Pathway Converts Mesenchymal Cells to Amelogenin-expressing Dental Epithelial Cells

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