The plasma catecholamine stress response is characteristic for a given animal over a one-year period

Taylor, J.; Weyers, Peter; Harris, Nina; Vogel, Wolfgang

doi:10.1016/0031-9384(89)90048-6

Cited by 23 publications

(12 citation statements)

References 11 publications

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“…For example, it is known that increases in plasma catecholamine in response to stress is much greater in female rats (Livezey et al, 1985;Taylor et al, 1989;Weinstock et al, 1998) and in women (Frankenhaeuser et al, 1976). Although the site of action of sex steroids on the sympathoadrenal system is unknown, and an action in the CNS cannot be excluded (Hinojosa-Laborde et al, 1999), the presence of estrogen receptor on female adrenal medullary cells provides support for the suggestion that these cells are the target for estrogen's action.…”

Section: Sympathoadrenal Axismentioning

confidence: 81%

“…Of note, the sympathetic and sympathoadrenal stress axes are sexually dimorphic; for example, female rats exhibit higher basal (DeTurck and Vogel, 1980) and stimulated (Livezey et al, 1985;Taylor et al, 1989) plasma epinephrine and norepinephrine levels, muscle sympathetic nerve activity (burst frequency and burst incidence) is higher in women (Ng et al, 1993), and stress-induced increases in plasma norepinephrine in men are enhanced by estradiol treatment (Kirschbaum et al, 1996). In addition, androgens also modulate sympathoadrenal activity in male rats (Le Thu et al, 1984) and men (Del Rio et al, 1995).…”

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confidence: 99%

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Sex Steroid Regulation of the Inflammatory Response: Sympathoadrenal Dependence in the Female Rat

et al. 1999

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To investigate the role of sex steroids in sex differences in the response of rats to the potent inflammatory mediator bradykinin (BK), we evaluated the effect of sex steroid manipulation on the magnitude of BK-induced synovial plasma extravasation (PE). The magnitude of BK-induced PE is markedly less in females. Ovariectomy of female rats increased BK-induced PE, and administration of 17␤-estradiol to ovariectomized female rats reconstituted the female phenotype. Castration in male rats decreased BK-induced PE, and administration of testosterone or its nonmetabolizable analog dihydrotestosterone reconstituted the male phenotype. The results of these experiments strongly support the role of both male and female sex steroids in sex differences in the inflammatory response.Because the stress axes are sexually dimorphic and are important in the regulation of the inflammatory response, we evaluated the contribution of the hypothalamic-pituitaryadrenal and the sympathoadrenal axes to sex differences in BK-induced PE. Neither hypophysectomy nor inhibition of corticosteroid synthesis affected BK-induced PE in female or male rats. Adrenal denervation in females produced the same magnitude increase in BK-induced PE as adrenalectomy or ovariectomy, suggesting that the adrenal medullary factor(s) in females may account for the female sex steroid effect on BK-induced PE. Furthermore, we have demonstrated that in female but not male rats, estrogen receptor ␣ immunoreactivity is present on medullary but not cortical cells in the adrenal gland. These data suggest that regulation of the inflammatory response by female sex steroids is strongly dependent on the sympathoadrenal axis, possibly by its action on estrogen receptors on adrenal medullary cells.

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Section: Sympathoadrenal Axismentioning

confidence: 81%

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confidence: 99%

Sex Steroid Regulation of the Inflammatory Response: Sympathoadrenal Dependence in the Female Rat

et al. 1999

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“…The heterogeneity of reinstatement was more pronounced in females, as the range of active lever responding to CRF greatly exceeded that of males (range for females=0–278, males=0–114), and females displayed significantly more variable responding than males. Since individual sensitivity to stressful stimuli is well documented in other paradigms [35–38], the individual variability to the effects of CRF on cocaine seeking is not surprising. Previous reports on CRF-induced reinstatement in males have demonstrated variable and modest results [39, 40].…”

Section: Discussionmentioning

confidence: 99%

Corticotrophin releasing factor (CRF) induced reinstatement of cocaine seeking in male and female rats

Buffalari¹,

Baldwin²,

Feltenstein³

et al. 2012

Physiology & Behavior

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Significant sex differences have been demonstrated in clinical and preclinical studies of cocaine addiction, with some of the most consistent differences noted in regards to the role of stress and craving. The current study examined stress-induced reinstatement of cocaine seeking in male and female rats in an animal model of relapse using corticotropin-releasing factor (CRF) administration. Both male and female rats demonstrated increased cocaine seeking in response to CRF. CRF-induced reinstatement was highly variable across both male and female rats, and further analysis revealed a subpopulation that was particularly sensitive to CRF (high responders). Female high responders displayed significantly increased responding to CRF compared to males. Individual differences in stress responsivity could thus contribute to the likelihood of relapse, with females showing greater heterogeneity to stress-induced relapse.

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“…Alternatively, some studies assess the “best” level of footshock and adjust accordingly for each rat prior to the reinstatement test [31]. Since individual sensitivity to stressful stimuli is well-documented in other paradigms [6, 30], it is not surprising that individual variability to the effects of stress on drug-seeking are seen in relapse paradigms.…”

Section: Discussionmentioning

confidence: 99%

Footshock stress potentiates cue-induced cocaine-seeking in an animal model of relapse

Buffalari

See

2009

Physiology & Behavior

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Drug-associated cues and stress increase craving and lead to greater risk of relapse in abstinent drug addicts. This risk may be increased when these factors occur simultaneously. The current study examined whether the presentation of three different levels of intermittent footshock would trigger reinstatement or potentiate reinstatement of cocaine-seeking caused by conditioned cues. Male, Long Evans rats underwent daily i.v. cocaine self-administration, followed by extinction of lever responding in the absence of previously cocaine-paired cues. Reinstatement of cocaine-seeking was measured during presentation of cocaine-paired cues, following pretreatment with three levels of intermittent footshock (0.25, 0.5, and 0.75 mA), or after the combination of footshock and cues. Footshock at the 0.5 and 0.75 mA levels led to significant reinstatement when presented alone, and also potentiated the reinstatement triggered by the presentation of conditioned cues. These results demonstrate that while stress and drug-paired cues reinstate drug-seeking when presented in isolation, their interaction leads to potentiated reinstatement. Dual targeting of stress and cues is thus a critical consideration for treatment intervention in abstinent drug users.

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The plasma catecholamine stress response is characteristic for a given animal over a one-year period

Cited by 23 publications

References 11 publications

Sex Steroid Regulation of the Inflammatory Response: Sympathoadrenal Dependence in the Female Rat

Sex Steroid Regulation of the Inflammatory Response: Sympathoadrenal Dependence in the Female Rat

Corticotrophin releasing factor (CRF) induced reinstatement of cocaine seeking in male and female rats

Footshock stress potentiates cue-induced cocaine-seeking in an animal model of relapse

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