The plasma membrane of erythrocytes plays a fundamental role in the transport of oxygen, carbon dioxide and nitric oxide and in the maintenance of the reduced state of the heme iron

Rosa, Maria Cristina De; Alinovi, Cristiana Carelli; Galtieri, Antonio; Scatena, Roberto; Giardina, Bruno

doi:10.1016/j.gene.2007.02.048

Cited by 45 publications

(43 citation statements)

References 53 publications

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“…35 Particularly, when the membrane fluidity is altered (for example chemically, with forming cholesterol-enriched membrane), 36 the membrane rearrangement changes the oxygen transport. To analyze the effect of cND on this RBC function, we study the process of oxygenation/deoxygenation.…”

Section: Resultsmentioning

confidence: 99%

“…43,44 The influence of cND on the RBC's mechanical properties is observed via variations of the cell deformability related to its membrane rigidity, which depends on the membrane structure and connects with the membrane functionality. 35,36,45,46 The dependencies of the cell deformability on the shear stress for normal RBC and RBC incubated with 100 nm cND in different concentrations are shown in Fig. 9.…”

Section: Resultsmentioning

confidence: 99%

“…35 The membrane structural changes created by cND interaction affect the RBC function, and thus can be reasons of the variations in the oxygenation-deoxygenation dynamics. Generally, it has been accepted that the oxygen can penetrate the RBC membrane via direct diffusion.…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, it has been already shown that the organic phosphate, i.e., 2,3-diphosphoglycerate (2, 3 DPG) in the RBC, binds with Hb (with β-sheets) and affects the Hb affinity to oxygen (oxygen binding capacity), facilitating the detaching O 2 from Hb molecule. 35 It is important that 2, 3 DPG is involved in the interaction of Hb with membrane, particularly with the band three protein. Thus, varying membrane state can vary conditions of 2, 3 DPG interaction with the membrane; and correspondingly, the interaction between Hb and 2, 3 DPG changes.…”

Section: Resultsmentioning

confidence: 99%

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The influence of nanodiamond on the oxygenation states and micro rheological properties of human red blood cells <italic>in vitro</italic>

et al. 2012

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

The influence of nanodiamond on the oxygenation states and micro rheological properties of human red blood cells <italic>in vitro</italic>

et al. 2012

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“…This property gives the red cell volume, plasticity and inherent pore sizes. Recent studies show that deoxy-haemoglobin binds to the amino terminus of Band 3 at a location adjacent to key cytoskeletal proteins [1,2]. 2,3 DPG also binds to the red cell cytoskeleton where its effect is to loosen the linkages between cytoskeletal ankyrin, Band 3 and protein 4.1.…”

mentioning

confidence: 99%

Three respiratory gases and the red cell: oxygen, carbon dioxide and nitric oxide

Dzik

2010

ISBT Science Series

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Three vital gases -oxygen, carbon dioxide and nitrogen -intersect at the level of the human red blood cell. The delivery of oxygen to all tissues by red cells is essential to human life. Evolution has created a complex molecule, haemoglobin, designed for efficient uptake and off-loading of oxygen. Iron rests at the centre of the haeme moiety and is critical for oxygen exchange. Although studied for over a century, some details of oxygen transport by the red cell remain uncertain. Recent research has focused on the interaction of haemoglobin with a complex of cellmembrane proteins centred on band 3. In addition, there is renewed interest in the question of whether or not stored red cells deliver oxygen to tissues as well as fresh red cells. The interactions of CO 2 with the red cell have drawn far less research attention. Plasma CO 2 released by tissues serves as an essential trigger for oxygen release by haemoglobin via the Bohr effect. CO 2 transport depends on conversion of CO 2 to bicarbonate via red cell carbonic anhydrase in conjunction with chloride exchange across the red cell membrane. There is very little research on the effect of blood storage on CO 2 excretion although this aspect of respiratory physiology is every bit as important as oxygen delivery. Nitric oxide (NO) physiology is directly related to oxygen delivery by the red cell. NO serves a local vasodilator to increase blood flow to hypoxic tissue beds. NO binds strongly to haemoglobin which serves as an NO sink. Under normal conditions, plasma NO synthesized by endothelial cells is not consumed by red cell haemoglobin because of a diffusion blockade across the red cell membrane that results from membrane structures not fully identified. Under conditions of red cell lysis, free haemoglobin scavenges NO reducing local vasodilation. Scavenging of NO is now recognized as an important component of the physiologic response to chronic haemolysis and is very likely to play an important role in the renal lesion of acute haemolysis. The three RBC gases are also the three principal gases of the Earth's atmosphere. While CO 2 is the least abundant of the three by far, it is also likely to be the most critical to the future survival of life on Earthbecause small further increases in the concentration of CO 2 will result in continued climate change, and large increases will be deadly. Thus, the management of three vital gases by the collection of red cells found within us has broad similarities to the collective management of our atmosphere. Just as the survival of individual tissue cells depends upon proper balance of these three respiratory gases, so too will their proper balance be the key to survival of life on Earth.The reversible binding of oxygen to haemoglobin is an event vital to the life of many species including humans. Oxygen binds co-operatively to haemoglobin such that oxygenation of one globin chain facilitates oxygenation of the other chains in the haemoglobin tetramer. At the centre

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Red blood cell metabolism and preservation

Hess¹,

D’Alessandro²

2022

Rossi's Principles of Transfusion Medicine

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The plasma membrane of erythrocytes plays a fundamental role in the transport of oxygen, carbon dioxide and nitric oxide and in the maintenance of the reduced state of the heme iron

Cited by 45 publications

References 53 publications

The influence of nanodiamond on the oxygenation states and micro rheological properties of human red blood cells <italic>in vitro</italic>

The influence of nanodiamond on the oxygenation states and micro rheological properties of human red blood cells <italic>in vitro</italic>

Three respiratory gases and the red cell: oxygen, carbon dioxide and nitric oxide

Red blood cell metabolism and preservation

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