The Platelet Count, Platelet Adhesiveness and Aggregation and the Mechanism of Fibrinolytic Inhibition in Pregnancy and the Puerperium

Shaper, A. G.; Kear, D.T.M. H. Jill; Kyobe, Ch.B. J.; Njama, Denise

doi:10.1111/j.1471-0528.1968.tb00140.x

Cited by 34 publications

(12 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By contrast, Shaper et al (1968), reporting on the second largest number of patients, found a consistent fall in platelet counts during pregnancy. In the remaining nine studies, the number of pregnant women studied was small.…”

Section: Discussionmentioning

confidence: 81%

“…Five groups of workers reported that there was no significant change in the platelet count during pregnancy (Bland et al, 1930;Fresh et al, 1956;Kennan and Bell, 1957;Ratnoff et al, 1954;Todd et al, 1965). By way of contrast, there were three reports of a progressive fall in platelet counts during pregnancy (Bonnar et al, 1969;Shaper et al, 1968;Ward and MacArthur, 1948).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Platelet counts during normal pregnancy.

Sejeny¹,

Eastham²,

Baker³

1975

J Clin Pathol

View full text Add to dashboard Cite

SYNOPSIS Eleven reports of platelet counts were found in the literature which reported a progressive increase, no change, or a progressive fall during pregnancy. The counts had been made using venous or capillary blood, with either simple dilution or red cell lysis prior to enumeration in a haemocytometer, with or without phase-contrast microscopy. It was therefore decided to examine whole blood platelet counts taken during normal pregnancy. Results from 405 venous blood samples, using an electronic platelet counter, confirmed the finding of a significant progressive fall in platelet counts during normal pregnancy, the lowest counts falling in some women outside the recognized normal range of values.

show abstract

Section: Discussionmentioning

confidence: 81%

mentioning

confidence: 99%

Platelet counts during normal pregnancy.

Sejeny¹,

Eastham²,

Baker³

1975

J Clin Pathol

View full text Add to dashboard Cite

show abstract

“…The platelet count during pregnancy has been the subject of conflicting reports; a continuous increase in the platelet count during pregnancy was reported by Mor et al (1960), and Shaper et al (1968) recorded a progressive decrease as pregnancy advanced.…”

Section: Resultsmentioning

confidence: 98%

Fibrinolytic Enzyme System and Pregnancy

Bonnar¹,

McNicol²,

Douglas³

1969

BMJ

145

View full text Add to dashboard Cite

Smmary: The effect of pregnancy on the components of the fibrinolytic enzyme system was determined by serial observations on 10 healthy women during normal pregnancy, labour, and the puerperium. The The haemostatic mechanism in pregnancy appears to be altered towards an enhanced capacity to form fibrin and a diminished ability to lyse fibrin. These changes may be a physiological development to ensure the integrity of the foetal and maternal circulations and provide rapid and effective haemostasis in the uterus during and after placental separation. Nevertheless, the changes may also establish a vulnerable state for intravascular fibrin deposition. Introduction The fibrinolytic enzyme system or plasminogen-plasmin system has a physiological role complementary to the coagulation mechanism in maintaining the patency of the blood vessels by promoting the removal of intravascular fibrin. The behaviour of the fibrinolytic mechanism in human pregnancy is therefore of special interest because an increase in the concentration of certain coagulation factors, particularly fibrinogen, is known to occur as pregnancy advances. Fibrinolytic activity has been reported to be decreased in late pregnancy, but many of the previous reports are single observations obtained under varying conditions and conflicting results have been presented. The purpose of this investigation was to elucidate the changes in the components of the fibrinolytic enzyme system induced by pregnancy and parturition by serial observations on a group of healthy women followed throughout normal pregnancy, labour, and the puerperium.According to current concepts the coagulation and fibrinolytic systems may be in a state of dynamic equilibrium which keeps the vascular compartment intact and patent, the coagulation system laying down fibrin on the vascular endothelium to seal any gaps which may occur, and the fibrinolytic system removing such fibrinous deposits after they have served their

show abstract

“…In most studies, no significant changes were observed, 11,15,21,26,27 while in others, like our own, a slight reduction was found. 15,28,29 In contrast to these findings, Mor et al 30 found a marked and progressive increase in the platelet count during pregnancy and a sharp drop at the time of placental delivery. As with antithrombin III, the fluctuations in platelet counts, though statistically significant, were within the normal range for nonpregnant controls.…”

Section: Discussionmentioning

confidence: 52%

“…In contrast, other investigators could not establish any differences between pregnant and nonpregnant women. 28,42 The recently reported increase in the plasma levels of thromboxane B2 and its release from thrombin-induced platelet aggregates in pregnant women suggests enhanced in vivo platelet activity during pregnancy. 43 In conclusion, the various changes in the hemostatic variables, especially the increase in clotting factor levels, in Saudi pregnant women are similar to many previously published results and support the description of pregnancy being a "hypercoagulable state" 2,44 that assures rapid and effective hemostasis during parturition.…”

Section: Discussionmentioning

confidence: 99%

Hemostasis in Pregnant Saudi Women

et al. 1990

View full text Add to dashboard Cite

A cross-sectional study of various hemostatic variables was undertaken in women during the three trimesters of normal pregnancy. In the third trimester of pregnancy, there was significant elevation of plasma fibrinogen, 55%; factor VIII activities, 64%; factor VIII:ristocetin cofactor, 44% ; factor VIII-related antigen, 49% ; factor X, 9% ; and plasminogen, 19%, and a reduction of antithrombin III, 10%; alpha2-antiplasmin, 7%; and platelet count, 20%, compared with those values obtained in healthy nonpregnant controls. These fluctuations developed gradually during the first and second trimesters. Prothrombin time, partial thromboplastin time, thrombin time, and reptilase time were similar in pregnant women and nonpregnant controls. Platelet aggregation in response to adenosine diphosphate, collagen, adrenaline, and arachidonic acid was significantly reduced in pregnant women compared to controls. The reduced platelet aggregability in Saudi pregnant women may counterbalance the increased plasmatic coagulation potential, thereby minimizing the risk of thromboembolic disease during pregnancy.

show abstract

The Platelet Count, Platelet Adhesiveness and Aggregation and the Mechanism of Fibrinolytic Inhibition in Pregnancy and the Puerperium

Cited by 34 publications

References 25 publications

Platelet counts during normal pregnancy.

Platelet counts during normal pregnancy.

Fibrinolytic Enzyme System and Pregnancy

Hemostasis in Pregnant Saudi Women

Contact Info

Product

Resources

About