The polarographic behavior and determination of glafenine

Differential pulse cathodic voltammetric determination of floctafenine and metopimazine

“…1). This peak was not observed in the polarogram of the closely related drug, glafenine [12], therefore this reduction peak can be attributed to the trifluoromethyl group which is located at C 8 in the quinoline moiety of FFN while glafenine lacks this group. A proposed mechanism concerning the reduction of this functional group is shown in the following scheme.…”

“…Examples of these compounds are the closely related compound, glafenine [12] which showed a cathodic polarographic wave at −1.145 V in B-R buffer pH 8.5, doxazocin [13] giving a reduction peak at −1.33 V and buspirone hydrochloride and piribedil [14] which showed voltammetric signals at about −1.2 V in B-R buffer pH 7.0.…”

Quantification of Pyritinol in Solid Pharmaceutical Formulation by High-Performance Thin-Layer Chromatography-Ultraviolet Detection and Selectivity Evaluation by Mass Spectrometry

“…[6] However, together with its beneficial properties, some serious adverse effects were attributed lately, i.e., cholestatic hepatitis [1] and acute pancreatitis. [7] Through all these years, several analytical methods have been used to determine pyritinol in pharmaceutical formulations and other matrices, e.g., UV [8] and Vis spectrophotometry, [9] derivative spectrophotometry, [10] polarography, [11] ion-pair high-performance liquid chromatography (HPLC), [12] and conductimetry. [13] Thin-layer chromatography (TLC) has been used in combination with principal component analysis and other chromatographic techniques for simultaneous qualitative analysis of several drugs, including pyritinol.…”