The polarographic behavior of the antitumor agent tauromustine and assay of its tablets

Abstract

Tauromustine was found to be reducible at the dropping mercury electrode (DME) over the whole pH range in Britton-Robinson (BR) buffers. A well-defined cathodic wave was produced in the acid range, followed by an ill-defined, more negative additional wave starting from pH 4.0. The main reduction wave was characterized as being diffusion-controlled, although adsorption phenomena played a limited role in the electrode process. Using either direct current or differential pulse polarographic modes, the limiting current-concentration plot is linear over a convenient range with a minimum detectability of 5 x successfully analyzed adopting the United States Pharmacopoeia (USP) content uniformity test.

Voltametric Determination of Vancomycin in Dosage Forms through Treatment with Nitrous Acid

“…The wave height of nitroso vancomycin was compared with that obtained from an equimolar solution of a previously studied compound, which has a nitroso functional group and nearly identical value of diffusion coefficient, i.e. tauromustine [22]. In BRb pH 4 both compounds gave one well-defined wave of the same height corresponding to a two electrons transfer process.…”

Voltammetric determination of nitrosocimetidine in simulated gastric juice

“…The number of electrons transferred during the reduction process was investigated by comparing the wave height of MNCM with that obtained from an equimolar solution of a previously studied compound having the same functional group (nitroso group) and of nearly the same value of diffusion coefficient (tauromustin) (23). In 0·1 m HCl pH 1·0, the wave heights of the two compounds were nearly the same indicating that two electrons were transferred during the reduction process, from which it is concluded that the depolarizer contains one nitroso group.…”