The Polymorphism of DNA Repair Gene ERCC2/XPD Arg156Arg and Susceptibility to Breast Cancer in a Chinese Population

Yin, Jinfang; Liang, Dan; Vogel, Ulla; Chang, Yaping; Liu, Zhengrong; Li, Yue; Sun, Xiaofeng; Qi, Rong; Song, Tiehua

doi:10.1007/s10528-009-9246-2

Cited by 7 publications

(6 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There were more subjects with family history of cancer (defined as first or second degree relatives) among cases (11.9%) than among controls (0.9%) (P b 0.001) ( Table 1). The minor allele frequencies were 0.10 for XRCC1 Pro206Pro and 0.48 for ERCC2 Arg156Arg among controls, respectively, and thus similar to our previous reports (Table 2) (Yin et al, 2007(Yin et al, , 2008(Yin et al, , 2009a. The genotype distributions of XRCC1 Pro206Pro and ERCC2 Arg156Arg among healthy controls were consistent with those predicted from Hardy-Weinberg equilibrium (P = 0.80 and P = 0.87, respectively) ( Table 2).…”

Section: Resultssupporting

confidence: 89%

“…Genotypes were AA (432 bp), AG (432, 344 and 88 bp) and GG (344 and 88 bp). For ERCC2 Arg156Arg, the genotyping data were published previously (Yin et al, 2009a).…”

Section: Laboratory Genotypingmentioning

confidence: 99%

“…The XRCC1 gene contains 17 exons and spans~32.27 kb on chromosome 19q13.2 (Lamerdin et al, 1995; http://www.ncbi.nlm.nih.gov/gene). The gene ERCC2 (excision repair cross-complementing rodent repair deficiency, complementation group 2) (Gene ID: 2068) is involved in NER (nucleotide excision repair) and basal transcription pathway (Yin et al, 2009a). The genomic DNA of the ERCC2 gene comprises 23 exons and spans 19.20 kb on chromosome 19q13.3 (Benhamou and Sarasin, 2002;http://www.ncbi.nlm.nih.gov/gene).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

No evidence of association between the synonymous polymorphisms in XRCC1 and ERCC2 and breast cancer susceptibility among nonsmoking Chinese

Yin

Wang

Liang

et al. 2012

Gene

Self Cite

View full text Add to dashboard Cite

Section: Resultssupporting

confidence: 89%

“…Genotypes were AA (432 bp), AG (432, 344 and 88 bp) and GG (344 and 88 bp). For ERCC2 Arg156Arg, the genotyping data were published previously (Yin et al, 2009a).…”

Section: Laboratory Genotypingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

No evidence of association between the synonymous polymorphisms in XRCC1 and ERCC2 and breast cancer susceptibility among nonsmoking Chinese

Yin

Wang

Liang

et al. 2012

Gene

Self Cite

View full text Add to dashboard Cite

“…Consistently with their finding, we also found that the minor A allele of ERCC2 rs238406 was associated with high BPDE-DNA adduct levels and low DNA repair capacity. These results were also in line with three studies on ERCC2 rs238406 polymorphisms based on the Chinese population [48]–[50]. However, Lovatt et al [51] reported that those genotypes were associated with a low risk of skin cancer.…”

Section: Discussionsupporting

confidence: 87%

ERCC1 and ERCC2 Haplotype Modulates Induced BPDE-DNA Adducts in Primary Cultured Lymphocytes

Liu

et al. 2013

PLoS ONE

View full text Add to dashboard Cite

BackgroundBenzo[a]pyrene(B[a]P), and its ultimate metabolite Benzo[a]pyrene 7,8-diol 9,10-epoxide (BPDE), are classic DNA damaging carcinogens. DNA damage caused by BPDE is normally repaired by Nucleotide Excision Repair (NER), of which ERCC1 and ERCC2/XPD exert an indispensable role. Genetic variations in ERCC1 and ERCC2 have been related to DNA repair efficiency. In this study we used lymphocytes from healthy individuals to show that polymorphisms in ERCC1 and ERCC2 are directly associated with decreased DNA repair efficiency.Methods ERCC1 (rs3212986 and rs11615) and ERCC2 (rs13181, rs1799793 and rs238406) were genotyped in 818 healthy Han individuals from the northeast of China. BPDE induced DNA adducts in lymphocytes were assessed by high performance liquid chromatography (HPLC) in 282 randomly selected participants. The effect of ERCC1 rs3212986 and ERCC2 rs238406 on DNA damage caused by B[a]P was assessed with a modified comet assay.ResultsWe found that the variant genotypes of ERCC1 rs3212986 and ERCC2 rs238406 were associated with the high levels of BPDE-DNA adducts. Especially ERCC1 rs3212986 A-allele variant was significantly associated with the high BPDE-DNA adducts. Haplotype analysis showed that the ERCC1 haplotype AC (OR = 2.36, 95% CI = 1.84–2.97), ERCC2 haplotype AGA (OR = 1.51, 95% CI = 1.06–2.15) and haplotype block AGAAC (OR = 5.28, 95% CI = 2.95–9.43), AGCAC (OR = 1.35 95% CI = 1.13–1.60) were linked with high BPDE-DNA adducts. In addition, we found that the combined minor alleles of ERCC1 rs3212986 and ERCC2 rs238406 were associated with a reduced DNA repair capacity.ConclusionsOur results suggest that the variant genotypes of ERCC1 rs3212986 and ERCC2 rs238406 are associated with decreased repair efficiency of BPDE induced DNA damage, and may be predictive for an individual’s DNA repair capacity in response to environmental carcinogens.

show abstract

“…Therefore, an accompanying higher expression of another gene may confer increased cancer risk. Previous studies demonstrated that XPD codon 156 polymorphisms were associated with lung (20), bladder (21) and breast cancer (22) in Chinese populations. To the best of our knowledge, the present study was the first to demonstrate that the silent polymorphisms of XPD156 affect the risk of PCa.…”

Section: Discussionmentioning

confidence: 98%

Susceptibility of XPD and hOGG1 genetic variants to prostate cancer

et al. 2013

View full text Add to dashboard Cite

Abstract. DNA repair genes are important in maintaining genomic stability and integrity. DNA repair gene polymorphisms, such as those of the human homolog of 8-oxoguanine DNA glycosylase 1 (hOGG1) and excision repair cross-complementing rodent repair deficiency, complementation group 2̸Xeroderma pigmentosum complementation group D (ERCC2̸XPD), contribute to carcinogenesis. The aim of this study was to investigate the association of prostate cancer (PCa) risk with hOGG1 and ERCC2̸XPD genetic variants. A case-control study of 200 cases including 100 PCa patients and 100 healthy subjects was conducted. Two single-nucleotide polymorphisms (SNPs) (ERCC2/XPD Arg156Arg and hOGG1 Ser326Cys) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The results demonstrated a significant association of the XPD156 homozygous (AA, OR=3.80; 95% CI: 1.19-12.18; P=0.017), heterozygous (AC, OR=2.48; 95% CI: 1.02-6.35; P=0.033) and combined (AA+AC, OR=2.76; 95% CI: 1.18-6.84; P=0.011) mutant genotypes with a predisposition to high-risk PCa. In the stratified analysis, predisposition to high-risk PCa was also associated with the mutant genotypes of hOGG1 326 homozygous mutant (GG, OR=2.93; P=0.033). The results also showed that the A allele of XPD Arg156Arg and the G allele of hOGG1 Ser326Cys were associated with an increased risk of PCa (OR=1.86 and 1.62; 95% CI: 1.13-3.06 and 1-2.67, respectively). In conclusion, the findings of this study demonstrated that the ERCC2/XPD Arg156Arg and hOGG1 Ser326Cys polymorphisms increased the susceptibility to high-risk PCa.

show abstract

The Polymorphism of DNA Repair Gene ERCC2/XPD Arg156Arg and Susceptibility to Breast Cancer in a Chinese Population

Cited by 7 publications

References 28 publications

No evidence of association between the synonymous polymorphisms in XRCC1 and ERCC2 and breast cancer susceptibility among nonsmoking Chinese

No evidence of association between the synonymous polymorphisms in XRCC1 and ERCC2 and breast cancer susceptibility among nonsmoking Chinese

ERCC1 and ERCC2 Haplotype Modulates Induced BPDE-DNA Adducts in Primary Cultured Lymphocytes

Susceptibility of XPD and hOGG1 genetic variants to prostate cancer

Contact Info

Product

Resources

About