The polymorphism of the immunoglobulin heavy chain switch region gene in IgA nephropathy, Henoch-Sch�nlein nephritis and idiopathic nephrotic syndrome

Jin, Dong Kyu; Kohsaka, Takao; Kobayashi, Noboru

doi:10.1007/bf00857569

Cited by 4 publications

(3 citation statements)

References 8 publications

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“…In line with a previous report (Jin et al, 1993), the present analysis of some polymorphisms of IgA switch regions did not allow the identification of any gene of susceptibility at these loci, which occurred with IgA nephropathy (Demaine et al, 1986;Julian et al, 1987). In line with a previous report (Jin et al, 1993), the present analysis of some polymorphisms of IgA switch regions did not allow the identification of any gene of susceptibility at these loci, which occurred with IgA nephropathy (Demaine et al, 1986;Julian et al, 1987).…”

Section: Discussionsupporting

confidence: 67%

“…Nevertheless, susceptibility to HS cannot be due only to HLA genes: in fact, 35% of patients show HLA antigens different from DRB1*01 or DRB1*11, and 48% of healthy subjects do not suffer from HS, even if they have the HLA-DRB1 antigens linked with susceptibility. In line with a previous report (Jin et al, 1993), the present analysis of some polymorphisms of IgA switch regions did not allow the identification of any gene of susceptibility at these loci, which occurred with IgA nephropathy (Demaine et al, 1986;Julian et al, 1987). That does not rule out that either the regulation of IgA levels, which is genetically controlled, or other sequences of constant IgA genes may be further genetic factors of susceptibility to HS.…”

Section: Discussionsupporting

confidence: 67%

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Immunogenetics of Henoch–schoenlein Disease

Amoroso

Berrino

Canale

et al. 1997

European Journal of Immunogenetics

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In order to investigate the genetic basis of susceptibility to Henoch-Schoenlein purpura (HS), blood samples of 152 patients, 105 of whom had renal disease, were collected in a two-step study. The evaluation of DRB, DQB and DQA polymorphism was done by analysis of the restriction polymorphisms produced by TaqI enzyme. DRB1*07 was less frequent in patients than in the control group (gene frequency 0.09 and 0.18, respectively; P = 0.0023), whereas 64% of the patients were positive for DRB1*01 and/or DRB1*11 compared with 48% of the control group (P = 0.0069). Polymerase chain reaction-sequence-specific oligonucleotide (PCR-SSO) typing of DRB1*01- and DRB1*11-positive individuals did not show any deviation of frequencies of DRB1*01 subtypes between patients and controls, whereas among DRB1*11 subtypes DRB1*1104 was significantly increased in the patients (Pc = 0.033). The comparison between patients with renal disease and those without renal disease showed no significant differences in the frequency of the single DRB, DQB and DQA alleles. The study of restriction polymorphisms in the switch region of the constant genes alpha 1, alpha 2 and mu of the heavy chains of immunoglobulins, using the enzyme Sacl and a specific probe, did not show any difference between 44 patients and 54 controls. This study demonstrates that susceptibility to HS also has a genetic origin: on one hand, the presence of DRB1*01 or DRB1*11 makes disease onset easier; on the other hand, DRB1*07 could induce some resistance to the disease. It is suggested that, as well as for other diseases caused by an impaired immune response, single amino acids in a key position in the HLA-DRB molecule make it more or less easy to recognize some antigenic peptide, towards which an immune response leading to disease is triggered.

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Section: Discussionsupporting

confidence: 67%

Section: Discussionsupporting

confidence: 67%

Immunogenetics of Henoch–schoenlein Disease

Amoroso

Berrino

Canale

et al. 1997

European Journal of Immunogenetics

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“…Different information has been reached in parallel to the developments in the science of immunology related to the pathogenesis of HSP, which is a leukocytoclastic small vessel vasculitis. Many studies were performed in the light of this information, and different results were stated [20][21][22][23][24][25][26][27][28][29][30][31].…”

Section: Discussionmentioning

confidence: 99%

Interleukin 8 gene 2767 A/G polymorphism is associated with increased risk of nephritis in children with Henoch–Schönlein purpura

2011

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The objective of this study is to investigate the association between IL-8 gene 2767 G/A polymorphism and clinical features, kidney involvement and prognosis in childhood Henoch Schnölein purpura (HSP). A total of 115 patients with HSP (59 male, 56 female) were included in the study with age at diagnosis between 2 and 17 years (8.0 ± 3.0). Hundred and eight healthy adults were included in the study as controls. The patients had been followed up for kidney involvement for at least 6 months and in average 8.2 ± 7.5 months. Interleukin 8 (IL-8) gene 2767 G/A polymorphism was studied by PCR-RFLP method. Frequency of the "A" allele was 0.37 in the patient group, whereas it was 0.36 in the control group. The difference was not statistically significant (P = 0.696). No association was detected between the IL-8 gene G/A polymorphism and the clinical, laboratory, and demographic data related to the patients with HSP. Kidney involvement was more common in those with the G/A polymorphism of the IL-8 gene. While a 0.44 frequency of the "A" allele was detected in those with kidney involvement, this rate was 0.29 in those with no kidney involvement (P = 0.046). Follow-up of those with the "A" allele revealed higher proteinuria (P = 0.023, odds ratio 0.176, 95% CI 0.034-0.917) and higher creatinine levels (P = 0.049, odds ratio 0.024, 95% CI 0.036-0.094). These results suggest that the kidney involvement is more common in patients with the "A" allele, and degree of proteinuria and creatinine levels is higher in these patients at follow-up.

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Immunoglobulin A Nephropathies in Children (Includes HSP)

Nakanishi

Yoshikawa

2014

Pediatric Nephrology

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The polymorphism of the immunoglobulin heavy chain switch region gene in IgA nephropathy, Henoch-Sch�nlein nephritis and idiopathic nephrotic syndrome

Cited by 4 publications

References 8 publications

Immunogenetics of Henoch–schoenlein Disease

Immunogenetics of Henoch–schoenlein Disease

Interleukin 8 gene 2767 A/G polymorphism is associated with increased risk of nephritis in children with Henoch–Schönlein purpura

Immunoglobulin A Nephropathies in Children (Includes HSP)

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