The poor-responder patient in an in vitro fertilization-embryo transfer program

Ben‐Rafael, Zion; Feldberg, Dov

doi:10.1007/bf01207732

Cited by 22 publications

(5 citation statements)

References 18 publications

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“…Since there is no consistent definition of poor responders in the literature, the above thresholds were selected because they represent the lowest 10% of ovarian responsiveness among patients who participated in this study. These definitions are similar to others previously described (20)(21)(22). Forty-six more women who had been previously treated in our IVF clinic were selected as "good responders."…”

Section: Methodsmentioning

confidence: 73%

FSH receptor gene polymorphisms have a role for different ovarian response to stimulation in patients entering IVF/ICSI-ET programs

Loutradis¹,

Patsoula²,

Minas

et al. 2006

J Assist Reprod Genet

100

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Purpose:To examine the frequency distribution of the Ser680Asn polymorphism of the follicle-stimulating hormone receptor (FSHR) gene in ovarian dysfunction (OD) infertile women, "poor responders" (PR) and "good responders" (GR). Methods:The hormonal profiles and treatment of all patients were analyzed and FSHR polymorphism was examined by PCR and RFLP. Women from all groups were classified as Asn/Asn, Asn/Ser, and Ser/Ser genotypes. Results: The frequency distribution of Ser/Ser, Asn/Ser and Asn/Asn variants in OD patients was 45.5, 22.7, and 31.8%, respectively. Day 3 FSH levels in OD and GR patients were higher in Ser/Ser and Asn/Asn subgroups. Asn/Ser carriers from OD and GR groups provided more follicles and oocytes compared to other allelic variants. Conclusions: GR patients carry more often the Asn/Ser genotype. The latter is correlated with more follicles and oocytes in both OD and GR patients. The Ser/Ser variant might be related to higher serum FSH levels, while the Asn/Ser with lower.

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Section: Methodsmentioning

confidence: 73%

FSH receptor gene polymorphisms have a role for different ovarian response to stimulation in patients entering IVF/ICSI-ET programs

Loutradis¹,

Patsoula²,

Minas

et al. 2006

J Assist Reprod Genet

100

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“…Some authors have tried to reduce GnRH-a doses or to stop its administration during exogenous gonadotropin stimulation to improve ovarian responsiveness, although the results have been contradictory. Higher estradiol levels were achieved with lower doses of gonadotropins, increasing cost-effectiveness, but PR's were unchanged (26,27). Several groups have tried discontinuation protocols with varying success.…”

Section: Discussionmentioning

confidence: 99%

Untitled

Schächter

Friedler

Raziel

et al. 2001

Journal of Assisted Reproduction and Genetics

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Discontinuation of GnRH-a during ovarian stimulation for IVF has a beneficial, but not statistically significant, effect on both E2 and oocyte production. Embryo cleavage rates and morphology were significantly improved, this may be due to improved oocyte quality, which may have been responsible for achieving pregnancies. The efficacy of gonadotropin treatment was enhanced when GnRH-a was discontinued. These results hint that GnRH-a may have a direct negative effect on folliculogenesis and oocytes, which is apparent especially in poor responder patients.

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“…By using a smaller dose of short-acting patient had a premature LH surge; a respectable 28% pregnancy rate per attempt was achieved in these low GnRHa (Triptorelin or leuprolide) to produce pituitary suppression; further reducing the dose at the start of responders (39). A decrease in ovarian volume measured by transva-COH produced better results for low responders (31)(32)(33). The flare-up regimen of GnRHa protocol is associ-ginal sonography (TVS) was reported to be associated with poor response to ovarian stimulation (40).…”

Section: Methodsmentioning

confidence: 99%