The Position of the Oxygen Dissociation Curve of Human Blood at High Altitude

Keys, Ancel; Hall, F. G.; Barrón, E. S. Guzmán

doi:10.1152/ajplegacy.1936.115.2.292

Cited by 97 publications

(18 citation statements)

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“…The significance of the differences of the mean PO2 (6). However, the interest in these results lies not so much in the position of the normal dissociation curve at this altitude as in the difference between its position and that of the cases of sickle cell anemia or trait.…”

Section: Resultsmentioning

confidence: 86%

Oxygen Dissociation Curves in Sickle Cell Anemia and in Subjects With the Sickle Cell Trait

Becklake¹,

Griffiths²,

McGregor³

et al. 1955

J. Clin. Invest.

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Section: Resultsmentioning

confidence: 86%

Oxygen Dissociation Curves in Sickle Cell Anemia and in Subjects With the Sickle Cell Trait

Becklake¹,

Griffiths²,

McGregor³

et al. 1955

J. Clin. Invest.

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“…This was attributed to alkalemia of acclimatization, since a similar shift was observed in the lowlanders studied at the same altitude. Keys et al (1936) conducted a similar study in Peruvian highlanders living at 5340 m. They found that the standardized ODCs of the highlanders (measured at a cellular pH of 7.1) were right shifted with respect to lowlanders at sea level, but left shifted with respect to lowlanders at high altitude, the latter of which was attributed to a greater degree of acclimatization due to a longer period of exposure to high altitude. Because, however, the lowlanders at altitude exhibited a respiratory alkalosis (whereas the altitude residents had pH values similar to those of lowlanders at sea level), their ODCs at physiological pH were similar to those of the altitude residents.…”

Section: The Odc In Highlandersmentioning

confidence: 97%

“…These results were not reconciled with those previously reported. Keys et al (1936) studied the position of the ODC in acclimatizing lowlanders at six different altitudes, from sea level to 6140 m. The ODCs of the subjects at altitude standardized for pH were right shifted (P 50 increase of 3.5 mmHg). At physiological pH, the ODC's were left-shifted up to an altitude of approximately 4267 m, above which they became increasingly right-shifted.…”

Section: The Odc In Lowlanders At High Altitudementioning

confidence: 99%

The in-vivo oxyhaemoglobin dissociation curve at sea level and high altitude

Balaban

Duffin

Preiss

et al. 2013

Respiratory Physiology & Neurobiology

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Some animals have adapted to hypoxia by increasing their haemoglobin affinity for oxygen, but in vitro studies have not shown any change of haemoglobin affinity for oxygen in human high altitude natives or lowlanders acutely acclimatized to high altitude. We conducted the first in vivo study of the oxyhaemoglobin dissociation curve by progressively reducing arterial PO 2 while maintaining normocapnia in lowlanders at sea level, lowlanders sojourning at 3600m for two weeks and native Andeans at the same altitude. We found that the in vivo PO 2 at which haemoglobin is half-saturated (P 50 ) is higher in lowlanders at sea level (32 mmHg) than that measured in vitro (27 mmHg) and that lowlanders and highlanders do significantly increase the in vivo affinity of their haemoglobin for oxygen with exposure to high altitude. These results indicate the value of an in vivo approach for studying the oxyhaemoglobin dissociation curve.iii

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“…Methods: The methods employed were essentially those described by D. B. Dill in the high altitude report of Keys, Hall and Barron (1). Samples of blood (4 ml.…”

Section: Methodsmentioning

confidence: 99%

The Position of the Oxygen Dissociation Curve of the Blood in Normal Children and Adults 1

Morse¹,

Cassels²,

Holder³

et al. 1950

J. Clin. Invest.

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Oxyhemoglobin dissociation curves were determined in normal children and adults as a preliminary to a study of such curves in patients with cyanotic congenital heart disease. A comparison of the curves of normal children with those of normal adults showed that the dissociation curves of children tend to lie to the right of those of the adult. In order to confirm this observation, the study was extended to include more cases and a wide range of ages. Thi-s report presents the results of the study.The report consists of a comparison between the positions of the oxyhemoglobin dissociation curves of the child and the adult in a group of 21 children two to ten years of age and 22 adults 21 to 45 years of age. In addition, it includes oxygen dissociation data for six newborn infants less than one day old, for a group of 15 older infants varying in age from 11 days to two years, and for a group of nine pre-adolescents, adolescents and post-adolescents from 11 to 20 years of age. The older infants were included in order to determine whether the slight shift of the curve to the right in childhood is greater in infancy. The older children were studied in the hope of determining the approximate age at which the leftward shift to the normal adult position occurs. on the dissociation curve, usually between 20 and 90 per cent saturation. The samples when drawn were mixed with heparin and kept in ice water. After equilibration they were stored in sampling tubes over mercury and were kept in ice water until the analyses for carbon dioxide and oxygen by the Van Slyke-Neill manometric method (2) were completed. Analyses were completed within eight hours after drawing the sample. The oxygen and carbon dioxide concentrations of the gas phase of the tonometers were determined by Haldane analysis. SUBJECTS AND METHODS SubjectsThe pH,, of each equilibrated sample was calculated from the Table I gives for both children and adults the means and their standard errors, the standard deviations of distribution, and the "t" values which were calculated to test the significance of observed differences between the means of the PO2 values of children and those of adults at given percentage saturations. Figure 1 shows

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The Position of the Oxygen Dissociation Curve of Human Blood at High Altitude

Cited by 97 publications

References 0 publications

Oxygen Dissociation Curves in Sickle Cell Anemia and in Subjects With the Sickle Cell Trait

Oxygen Dissociation Curves in Sickle Cell Anemia and in Subjects With the Sickle Cell Trait

The in-vivo oxyhaemoglobin dissociation curve at sea level and high altitude

The Position of the Oxygen Dissociation Curve of the Blood in Normal Children and Adults 1

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