The position of the Radin blood group locus in relation to other chromosome 1 loci

Lewis, Marion; Kaita, Hiroko; Philipps, S.; Giblett, E. R.; Anderson, Jeanne E.; McAlpine, P.J.; Nickel, Birgit

doi:10.1111/j.1469-1809.1980.tb00956.x

Cited by 28 publications

(13 citation statements)

References 6 publications

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“…7 The latest data indicated a genomic position of 1p34 to 1p36. 8 A second low-frequency antigen, Radin (Rd; 700.015) shared this position 9,10 and was found on a protein of similar size. 11 Both anti-Sc2 12 and anti-Rd 13 are clinically relevant, having caused hemolytic disease of the newborn.…”

Section: Introductionmentioning

confidence: 98%

Scianna antigens including Rd are expressed by ERMAP

Wagner

Poole

Flegel

2003

Blood

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The Scianna blood group encompasses the high-frequency antigens Sc1 and Sc3 and the low-frequency antigen Sc2. Another lowfrequency antigen Rd (Radin) was suggested to belong to the Scianna blood group. The molecular basis of the Scianna blood group was unknown. The erythrocyte membrane-associated protein (ERMAP) shared the genomic location, protein product size, and localization to the red blood cell (RBC) membrane surface with Scianna. The ERMAP gene was sequenced in probands with known Scianna and Radin phenotypes. In a Sc:-1,-2 proband, only an ERMAP allele with a 2-bp deletion in exon 3 causing a frameshift could be detected. A Sc:-1,2 proband was homozygous for the ERMAP(Gly57Arg) allele. An Rd ؉ proband was heterozygous for the ERMAP(Pro60Ala) allele. Polymerase chain reaction with sequence-specific priming (PCR-SSP) systems was developed to detect the Sc2 and Rd alleles of the ERMAP gene. The 2 alleles occurred with about 1% and less than 1% frequency in the population, which was compatible with the frequency of the Sc2 and Rd antigens known in whites. Two Sc2 ؉ and one Rd ؉ samples that were found by genotyping were confirmed by serology.

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Section: Introductionmentioning

confidence: 98%

Scianna antigens including Rd are expressed by ERMAP

Wagner

Poole

Flegel

2003

Blood

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“…The data on which these lod scores are based are contained in or can be found from the following: Robson and King 1984;Lewis et al 1980Lewis et al , 1983Cosgriff et al 1983;Pericak-Vance et al 1982;Stebbins and Conneally 1982;Greiner et al 1983;van der Schroeff et al 1984;Darby et al 1985 and HGM8;Hilden et al HGM8;Rogde et al HGM8. Kohl et al (1983); myc related oncogene Kanda et al (1983);Schwab et al (1984); Shiloh et al (1985) p24-p22 D2S7 DNA fragment probe pXG5 Only new references and those not easily found from other HGM reports are given here.…”

mentioning

confidence: 99%

Report of the committee on the genetic constitution of chromosomes 1 and 2

Povey¹,

Morton²,

Sherman³

1985

Cytogenet Genome Res

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“…4 members of this kindred have the ability to remove anti-700.4 activity with 700:4,41 cells from the Croatian fami ly and from Swann, M.A.P. and J.W.…”

Section: Methodsmentioning

confidence: 99%

The Swann Phenotype 700:4,-41; Genetic Studies

Lewis¹,

Kaita²,

Philipps³

et al. 1988

Vox Sanguinis

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Serological analysis of the red cells from members of a large French-Canadian kindred proved that the Sw^a antigen is not part of the P1, Dombrock or Yt blood group systems. A linkage analysis of the AH7 blood group locus in relation to 27 other loci indicates that SW is not closely linked to ABO, ACPI, ADA, AK1, C3, D2S5, DO, ESD, F13A, EY, GLOl, GPT, HP, IGHG, JK, LU, MYCL, PI, PGP, PGM1, PLG, RH or YT. By inference the study also allows exclusion of Sw^a from the Landsteiner-Wiener, Radin and Scianna blood group systems and exclusion of SW from the p22.1 to p34 segment of chromosome 1.

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The position of the Radin blood group locus in relation to other chromosome 1 loci

Abstract: Summary Data are presented which indicate that the Radin blood group antigen is governed by a locus, for the present called Rd, which is located between PGM1 and αFUC Rh, and is either very closely linked to or identical with Sc.

Cited by 28 publications

References 6 publications

Scianna antigens including Rd are expressed by ERMAP

Scianna antigens including Rd are expressed by ERMAP

Report of the committee on the genetic constitution of chromosomes 1 and 2

The Swann Phenotype 700:4,-41; Genetic Studies

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