The Possibility of Increasing the Effectiveness of Correcting Motor Skills and Cognitive Functions Using Noninvasive Brain Stimulation in Humans

Popyvanova, Alena; Koriakina, M. A.; Pomelova, E. D.; Ilyukina, N. A.; Agranovich, Olga E.; Шестакова, Анна; Blagovechtchenski, Evgeny

doi:10.1007/s11055-023-01412-w

Cited by 2 publications

(4 citation statements)

References 128 publications

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“…In our opinion, the problem lies in the multidirectional effects of stimulation at different intensities and intragroup variabilities. Often, at the same stimulation intensity, different subjects have multidirectional responses, and an increase in the sample size can lead to the “ceiling” effect, where, even with pronounced stimulation of a significant part of the group of subjects, on average, we do not observe effects due to the multidirectional action of the other part of the group [ 3 , 11 ].…”

Section: Variability In Tdcs Resultsmentioning

confidence: 99%

“…When the central nervous system is the target of such an impact, the direct targets include the cerebral cortex, cerebellum, and spinal cord, due to the anatomical proximity of these structures to the surface [ 3 , 5 ]. However, they have pronounced structural differences, including a different laminar structure of the organization of neuronal layers, different structures of afferents and efferents, and different tissue configurations between the structure and the surface [ 3 , 6 , 7 ]. However, in relation to the anatomical features, the question arises of how to select the intensity of the impact on the desired structure.…”

Section: Major Targets In the Central Nervous Systemmentioning

confidence: 99%

“…The results of comparing the protocols used at different levels are of great interest. [ 3 , 5 , 33 ]. Thus, protocols using an impulse structure are rarely used to affect the cerebral cortex, which is a common approach for the spinal cord, likely because the mechanisms of stimulation have different purposes.…”

Section: Differences In Protocolsmentioning

confidence: 99%

“…Of particular interest herein, non-invasive brain stimulation is a widely used protocol that involves stimulation with a direct current, leading to long-lasting neuroplastic changes [ 1 , 2 ]. Active use of such stimulation is beginning to increase in clinics, as its advantages include simplicity and a low cost [ 3 , 4 ].…”

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confidence: 99%

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Using a Pulse Protocol to Fix the Individual Dosage of Transcranial and Transspinal Direct Current Electrical Stimulation

Blagovechtchenski

Kostromina

Шаболтас

2023

Life

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The non-invasive current stimulation protocol differs significantly between the brain and spinal cord, such that when comparing the two, there is a clear predominance of protocols using transcranial direct current stimulation (tDCS) for the brain and of protocols using pulsed stimulation for the spinal cord (psSC). These protocols differ in their effects on the central nervous system and in such important parameters as stimulation intensity. In most cases, tDCS has a fixed amplitude for all subjects/patients, while psSC is usually chosen on a case-by-case basis, according to the thresholds of muscle responses. In our opinion, it is possible to use the experience of identifying thresholds during psSC to adjust the dose of the direct current for transcranial and transspinal electrical stimulation, an approach that may provide more homogeneous tDCS data.

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Section: Variability In Tdcs Resultsmentioning

confidence: 99%

Section: Major Targets In the Central Nervous Systemmentioning

confidence: 99%

Section: Differences In Protocolsmentioning

confidence: 99%

mentioning

confidence: 99%

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Using a Pulse Protocol to Fix the Individual Dosage of Transcranial and Transspinal Direct Current Electrical Stimulation

Blagovechtchenski

Kostromina

Шаболтас

2023

Life

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Transspinal direct current stimulation with an intensity of 2.5 mA does not affect the corticospinal system excitability and motor skills

Pomelova,

Popyvanova,

Bredikhin

et al. 2023

Genes & Cells

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BACKGROUND: Non-invasive brain stimulation is an effective way to affect movement production, including the spinal cord level. It is known, that the stimulation effects are very sensitive to montage and protocols of applied stimulation, because it can involve different neuronal mechanisms. AIM: The purpose of the study was to estimate the effect of anodal transspinal direct current stimulation (tsDCS) with intensity 2,5 mA applied at the level of the cervical enlargement of the spinal cord (C7-Th1 segments) on the corticospinal system (CSS) excitability and motor skills. METHODS: The study involved 54 healthy adults aged 21,19 3,2 years. The effect of tsDCS was assessed using motor evoked potentials (MEP) from the first dorsal interosseous (FDI) muscle by transcranial magnetic stimulation in the primary motor cortex before stimulation, immediately after stimulation, and after 15 minutes. RESULTS: Our results showed that the application of an 11-minute anodal tsDCS at the level of the cervical spine C7-Th1 with a current value of 2.5 mA does not affect the MEP of FDI. The statistical analysis demonstrated that the dynamics of MEP amplitudes did not differ between groups receiving anodal tsDCS and sham stimulation. Also, anodal tsDCS did not affect motor skills. An individual's ability to coordinate fingers and manipulate objects effectively (a measure of dexterity) in 9-HPT, and pressing a key in response to a visual stimulus in SRT, did not differ from sham stimulation. CONCLUSION: Therefore, it can be assumed that 2.5 mA anodal tsDCS on the cervical enlargement of the spinal cord does not affect the CSS excitability or change motor skills associated with precise hand movements.

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The Possibility of Increasing the Effectiveness of Correcting Motor Skills and Cognitive Functions Using Noninvasive Brain Stimulation in Humans

Cited by 2 publications

References 128 publications

Using a Pulse Protocol to Fix the Individual Dosage of Transcranial and Transspinal Direct Current Electrical Stimulation

Using a Pulse Protocol to Fix the Individual Dosage of Transcranial and Transspinal Direct Current Electrical Stimulation

Transspinal direct current stimulation with an intensity of 2.5 mA does not affect the corticospinal system excitability and motor skills

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