The Possible Protective Role of Bone Marrow Transplantation against Alternations Induced by Gamma Radiations on Heart of Pregnant Albino Rats and Their Fetuses

Emam, Nahed Mohamed Mansour; Ibrahim, Mohamed T.

doi:10.5296/jbls.v4i1.3245

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…Increased total protein content of lung tissue post exposure to gamma radiation was recorded before by Mansour. [48] ; the author declared that the increase in staining affinity of total protein of lung tissues following gamma radiation exposure may be attributed to increased RBCs in the blood vessels and also to increased collagen fibres deposition. Increased staining affinity of both DNA and total protein may be due to the generation of ROS and consequent oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Effects of Olive Leaf Extract or Bone Marrow Mesenchymal Stem Cells against Lung Damage Induced in Male Albino Rats Exposed to Gamma Radiation

El-Hady

Aljalaud

2015

EJHM

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Aim of the work-This study aimed to investigate the histological and histochemical changes in the lung tissue of male albino rats post exposure to gamma radiation and the possible therapeutic effect of both olive leaf extract and bone marrow mesenchymal stem cells. Matrerial and methods-The current study was carried out on 40 adult male albino rats (Sprague dawely strain); they were divided equally into 5 groups (C group: control rats; O group : rats treated with olive leaves extract(15 mg /kg body weight/daily) ; R group: rats exposed to a single dose of gamma-radiation(3 Gy); RO group: rats of this group treated with olive extract 15 mg /kg body weight/daily one week before and one week after irradiation; RS group: rats of this group irradiated with 3Gy then treated with bone marrow mesenchymal stem cells (BMSCs) 3×10 6 cells/ml suspension through caudal vein about 5h post radiation exposure. Histopathological and histochemical changes were studied. Results-Rats exposed to gamma radiation showed numerous histological and histochemical changes, these changes were ameliorated by using either olive leaf extract or bone marrow mesenchymal stem cells. BMSCs showed more obvious therapeutic effect than olive leaf extract. Conclusion-The present work showed that olive leaf extract or bone marrow mesenchymal stem cells (BMSCs) have lung tissue radiotherapeutic effects against whole body gamma radiation in male albino rats.

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Section: Discussionmentioning

confidence: 99%

Therapeutic Effects of Olive Leaf Extract or Bone Marrow Mesenchymal Stem Cells against Lung Damage Induced in Male Albino Rats Exposed to Gamma Radiation

El-Hady

Aljalaud

2015

EJHM

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“…Such increase in collagen fibers deposition might lead to rapid healing process where increasing secretion of collagen subtype within the site of injury lead to replacing of necrotic tissue during the proliferative phase of the wound healing mechanism (Suvik & Effendy, 2012). The increased collagen fibers may lead to increase the defense reaction against toxic materials (Mansour et al, 2013). Increased collagen deposition may be due to oxidative stress that stimulates the expression of genes involved in collagen biosynthesis (Guler et al, 2009).…”

Section: Journal Of Biology and Life Sciencementioning

confidence: 99%

Maternal and Fetal Toxicity of Carisoprodol Drug (Somadril Compound) on Pulmonary Tissues of Albino Rats

Emam

2019

JBLS

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Carisoprodol is a common muscle relaxant indicated as adjunctive therapy in acute, painful musculoskeletal cases. This current study aimed to investigate the histopathological, histochemical and immunohistochemical effects in the lung tissue of the pregnant rats and their fetuses after carisoprodol treatment. The present study was applied on twenty seven pregnant female rats and they were randomly divided into three groups (nine pregnant female rats in each group). Rats of the first (control) group were administered oral doses of distilled water. Rats of the second (S1) and third groups (S2) were administered oral doses of carisoprodol in the distilled water equivalent to 10.8 mg and 21.6 mg/100g body weight/day respectively for fifteen days from the six to the twenty day of gestation. Several histopathological, histochemical and some immunohistochemical changes were studied to detect the pathological changes. Maternal and fetal pulmonary tissues of both treated groups showed numerous degenerative changes post-treatment with carisoprodol, the severity of these changes was more obvious in the fetal lung tissue of both groups. Also, carisoprodol treated rats showed a marked increase in caspase-3 content in the maternal and fetal pulmonary tissues. Treatment of pregnant rats with carisoprodol drug led to numerous dystrophic changes in both maternal and fetal lung tissues.

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Protective Role of Royal Jelly Against Gamma Radiation Induced Oxidative Stress, Cardio-Toxicity and Organ Dysfunctions in Male Rats

Sarhan

Naoum

2020

The Egyptian Journal of Hospital Medicine

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The Possible Protective Role of Bone Marrow Transplantation against Alternations Induced by Gamma Radiations on Heart of Pregnant Albino Rats and Their Fetuses

Abstract: Aim of the work: It is well recognized that radiation can be carcinogenic. Bone marrow cells (BM) suppress immune cell responses and have beneficial effects in various inflammatory-related immune disorders. The present study is designed to evaluate the

Cited by 4 publications

References 35 publications

Therapeutic Effects of Olive Leaf Extract or Bone Marrow Mesenchymal Stem Cells against Lung Damage Induced in Male Albino Rats Exposed to Gamma Radiation

Therapeutic Effects of Olive Leaf Extract or Bone Marrow Mesenchymal Stem Cells against Lung Damage Induced in Male Albino Rats Exposed to Gamma Radiation

Maternal and Fetal Toxicity of Carisoprodol Drug (Somadril Compound) on Pulmonary Tissues of Albino Rats

Protective Role of Royal Jelly Against Gamma Radiation Induced Oxidative Stress, Cardio-Toxicity and Organ Dysfunctions in Male Rats

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