The Possible Protective Role of the Il6-174GC Genotype in Dengue Fever

Moreira, S.T.; Cardoso, D.M.; Visentainer, J.E.; Fonzar, U.J.V.; Moliterno, R.A.

doi:10.2174/1874315301002010087

Cited by 2 publications

(2 citation statements)

References 32 publications

(38 reference statements)

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“…Correlation between TNF-α -308A allele and DHF has been reported earlier in patient population of Venezuela and Cuba 38 , 39 , but other studies did not find association in their group of patients 40 - 43 . A study in Mexico showed that the -238A allele was associated with protection of symptomatic dengue 41 .…”

Section: Discussionmentioning

confidence: 59%

High Producing Tumor Necrosis Factor Alpha Gene Alleles in Protection against Severe Manifestations of Dengue

et al. 2015

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Dengue virus (DENV) infection usually presents with mild self-limiting dengue fever (DF). Few however, would present with the more severe form of the disease, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). In the present study, the association between IL-12B, IL-10 and TNF-α gene polymorphisms and dengue severity was investigated. Methods: A case-control study was performed on a total of 120 unrelated controls, 86 DF patients and 196 DHF/DSS patients. The polymorphisms in IL-12B, IL-10 and TNF-α genes were genotyped using PCR-RFLP and PCR-sequencing methods. Results: A protective association of TNF-α -308A allele and -308GA genotype against DHF/DSS was observed, while TNF-α -238A allele and -238GA genotype were associated with DHF/DSS. A combination of TNF-α -308GA+AA genotype and IL-10 non-GCC haplotypes, IL-12B pro homozygotes (pro1/pro1, pro2/pro2) and IL-12B 3'UTR AC were significantly correlated with protective effects against DHF/DSS. An association between the cytokine gene polymorphisms and protection against the clinical features of severe dengue including thrombocytopenia and increased liver enzymes was observed in this study. Conclusion: The overall findings of the study support the correlation of high-producer TNF-α genotypes combined with low-producer IL-10 haplotypes and IL-12B genotypes in reduced risk of DHF/DSS.

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Section: Discussionmentioning

confidence: 59%

High Producing Tumor Necrosis Factor Alpha Gene Alleles in Protection against Severe Manifestations of Dengue

et al. 2015

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“…Some of these polymorphisms influence the level of cytokine production, which can confer flexibility in the immune response [98–101]. Thus, the presence of certain alleles may influence the course of bacterial and viral infections [102, 103] and confer susceptibility or resistance to autoimmune disease [104]. SNPs in cytokine genes have been described as important genetic factors in the occurrence of different clinical forms of Chagas disease.…”

Section: Genetic Factors and Their Influence On Chagas Diseasementioning

confidence: 99%

Genetic Susceptibility to Chagas Disease: An Overview about the Infection and about the Association between Disease and the Immune Response Genes

Ayo

Dalalio

Visentainer

et al. 2013

BioMed Research International

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Chagas disease, which is caused by the flagellate parasite Trypanosoma cruzi, affects 8–10 million people in Latin America. The disease is endemic and is characterised by acute and chronic phases that develop in the indeterminate, cardiac, and/or gastrointestinal forms. The immune response during human T. cruzi infection is not completely understood, despite its role in driving the development of distinct clinical manifestations of chronic infection. Polymorphisms in genes involved in the innate and specific immune response are being widely studied in order to clarify their possible role in the occurrence or severity of disease. Here we review the role of classic and nonclassic MHC, KIR, and cytokine host genetic factors on the infection by T. cruzi and the clinical course of Chagas disease.

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The Possible Protective Role of the Il6-174GC Genotype in Dengue Fever

Cited by 2 publications

References 32 publications

High Producing Tumor Necrosis Factor Alpha Gene Alleles in Protection against Severe Manifestations of Dengue

High Producing Tumor Necrosis Factor Alpha Gene Alleles in Protection against Severe Manifestations of Dengue

Genetic Susceptibility to Chagas Disease: An Overview about the Infection and about the Association between Disease and the Immune Response Genes

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