The possible role of XRCC1 gene polymorphisms with idiopathic azoospermia in south-east Turkey

Akbas, Halit; Balkan, Mahmut; Binici, Mahir; Gedik, Abdullah

doi:10.1016/j.jbiotec.2018.06.060

Cited by 7 publications

(7 citation statements)

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“…The endometrium becomes receptive between days 19 -23, of a normal human menstrual cycle, which is referred to as the window of implantation (WOI). This window is induced through increased levels of 17-b-estradiol and progesterone and results in several endometrial changes (10)(11)(12). Endometrial receptivity requires a well-orchestrated interplay of various cell types, such as epithelial cells (hEC), stromal (hESC), immune cells, and trophoblasts.…”

Section: Introductionmentioning

confidence: 99%

TNF-α Regulated Endometrial Stroma Secretome Promotes Trophoblast Invasion

et al. 2021

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Successful implantation requires the coordinated migration and invasion of trophoblast cells from out of the blastocyst and into the endometrium. This process relies on signals produced by cells in the maternal endometrium. However, the relative contribution of stroma cells remains unclear. The study of human implantation has major technical limitations, therefore the need of in vitro models to elucidate the molecular mechanisms. Using a recently described 3D in vitro models we evaluated the interaction between trophoblasts and human endometrial stroma cells (hESC), we assessed the process of trophoblast migration and invasion in the presence of stroma derived factors. We demonstrate that hESC promotes trophoblast invasion through the generation of an inflammatory environment modulated by TNF-α. We also show the role of stromal derived IL-17 as a promoter of trophoblast migration through the induction of essential genes that confer invasive capacity to cells of the trophectoderm. In conclusion, we describe the characterization of a cellular inflammatory network that may be important for blastocyst implantation. Our findings provide a new insight into the complexity of the implantation process and reveal the importance of inflammation for embryo implantation.

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Section: Introductionmentioning

confidence: 99%

TNF-α Regulated Endometrial Stroma Secretome Promotes Trophoblast Invasion

et al. 2021

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“…Then, one article (Gu et al., 2007) was excluded because of overlapping data through full‐text screening. Finally, six case–control articles with 1,886 patients and 1,212 controls were included in our meta‐analysis (Akbas et al., 2019; Garcia‐Rodriguez, et al., 2018; Ghasemi et al., 2017; Ji et al., 2010; Singh, Bansal, et al, 2019; Zheng et al., 2012). The detailed selection process was shown in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…Compared with two previous relative meta‐analyses (Ibrahimi et al., 2019; Singh, Bansal, et al, 2019), we added two new original articles (Akbas et al., 2019; Garcia‐Rodriguez, et al., 2018). In addition, we changed or deleted some papers which were included in previous studies.…”

Section: Discussionmentioning

confidence: 99%

“…Some reported that Arg‐related genotypes or allele indicated a high risk of male infertility (Garcia‐Rodriguez, de la Casa, Serrano, Gosalvez, & Roy Barcelona, 2018; Zheng et al., 2012). However, others found little statistic association between XRCC1 Arg399Gln and male infertility risk (Akbas, Balkan, Binici, & Gedik, 2019; Ji et al., 2010). Although two well‐designed meta‐analyses on this topic had been conducted in 2019 (Ibrahimi et al., 2019; Singh, Bansal, et al, 2019), more related articles were published thereafter.…”

Section: Introductionmentioning

confidence: 99%

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Association between X‐ray repair cross‐complementing group 1 Arg399Gln polymorphism and male infertility: An update meta‐analysis

et al. 2020

Andrologia

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“…Two SNPs in the XRCC1 gene were associated with increased bladder cancer risk among Asians [113], whilst another one, the R339Q, has been implicated in susceptibility for both idiopathic azoospermia and different types of cancer, such as hepatocellular cancer in Asians and breast cancer in Indians [114][115][116][117][118].…”

Section: Genetic Polymorphismsmentioning

confidence: 99%

Genetic Factors of Non-Obstructive Azoospermia: Consequences on Patients’ and Offspring Health

Krausz

Cioppi

2021

JCM

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Non-Obstructive Azoospermia (NOA) affects about 1% of men in the general population and is characterized by clinical heterogeneity implying the involvement of several different acquired and genetic factors. NOA men are at higher risk to be carriers of known genetic anomalies such as karyotype abnormalities and Y-chromosome microdeletions in respect to oligo-normozoospermic men. In recent years, a growing number of novel monogenic causes have been identified through Whole Exome Sequencing (WES). Genetic testing is useful for diagnostic and pre-TESE prognostic purposes as well as for its potential relevance for general health. Several epidemiological observations show a link between azoospermia and higher morbidity and mortality rate, suggesting a common etiology for NOA and some chronic diseases, including cancer. Since on average 50% of NOA patients has a positive TESE outcome, the identification of genetic factors in NOA patients has relevance also to the offspring’s health. Although still debated, the observed increased risk of certain neurodevelopmental disorders, as well as impaired cardiometabolic and reproductive health profile in children conceived with ICSI from NOA fathers may indicate the involvement of transmissible genetic factors. This review provides an update on the reproductive and general health consequences of known genetic factors causing NOA, including offspring’s health.

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The possible role of XRCC1 gene polymorphisms with idiopathic azoospermia in south-east Turkey

Cited by 7 publications

References 0 publications

TNF-α Regulated Endometrial Stroma Secretome Promotes Trophoblast Invasion

TNF-α Regulated Endometrial Stroma Secretome Promotes Trophoblast Invasion

Association between X‐ray repair cross‐complementing group 1 Arg399Gln polymorphism and male infertility: An update meta‐analysis

Genetic Factors of Non-Obstructive Azoospermia: Consequences on Patients’ and Offspring Health

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