The possible viral aetiology of disseminated sclerosis1

Cathala, F; Brown, P.

doi:10.1136/jcp.s3-6.1.141

Cited by 13 publications

(6 citation statements)

References 37 publications

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“…The involvement of measles virus in the slowly progressive neurological disease subacute sclerosing panencephalitis (SSPE) (2, 4, 10, 21) and its possible role in multiple sclerosis (5,14,15) have led to increased interest in the strategies of its replicative cycle. Preliminary characterization of virion polypeptides and RNA have been carried out, (3,7,8,17,37).…”

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confidence: 99%

Intracellular synthesis of measles virus-specified polypeptides

Wechsler¹,

Fields²

1978

J Virol

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The intracellular synthesis of measles-specified polypeptides was examined by means of polyacrylamide gel electrophoresis of cell extracts. Since measles virus does not efficiently shut off host-cell protein synthesis, high multiplicities of infection were used to enable viral polypeptides to be detected against the high background of cellular protein synthesis. The cytoplasm of infected cells contained viral structural polypeptides with estimated molecular weights of 200,

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confidence: 99%

Intracellular synthesis of measles virus-specified polypeptides

Wechsler¹,

Fields²

1978

J Virol

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“…Measles virus, normally associated with acute childhood infections, has been implicated in a slow persistent infection in children and young adults, namely subacute sclerosing panencephalitis (SSPE) (Baublis & Payne, 1968;Bouteille et al, 1965;Connoly et al, 1967;Horta-Barbosa et al, 1969), and has also been linked with multiple sclerosis (Cathala & Brown, 1972;Levy et al, 1976) and Paget's bone disease (Basl6 et al, 1979). Measles virus is antigenically stable, a single infection giving life-long immunity.…”

Section: Introductionmentioning

confidence: 99%

Monoclonal Antibodies Against Measles Virus

Giraudon¹,

Wild²

1981

Journal of General Virology

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“…Of course, our model is highly artificial, and one must be very cautious in extrapolation of the data obtained for the understanding of the pathogenesis of SSPE and another chronic infection apparently due to measles virus, i. e. disseminated sclerosis (6). The possible participation of an oncornavirus in SS1)E has been recently shown (9).…”

Section: Discussionmentioning

confidence: 98%

Integration of measles virus nucleic acid into the cell genome

Zhdanov

Parfanovich

1974

Archiv f Virusforschung

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SummaryA system of chick embryo fibroblasts chronically infected with measles virus has been obtained, which supported production of the infectious virus in low titres. Virus-specific ribonucleoprotein (200S, 1.31 g/ml) is synthesized in this system and no mature virions can be detected. Hybridization experiments showed that measles virus DNA-transcript is integrated into the cell genome. This may be due to the presence of a latent oncornavirus in chick embryo fibroblasts. Possible relation of the model studied to subacute selerosing paneneephalitis is discussed.

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The possible viral aetiology of disseminated sclerosis1

Cited by 13 publications

References 37 publications

Intracellular synthesis of measles virus-specified polypeptides

Intracellular synthesis of measles virus-specified polypeptides

Monoclonal Antibodies Against Measles Virus

Integration of measles virus nucleic acid into the cell genome

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