The Potential Benefits and Adverse Effects of Phytic Acid Supplement in Streptozotocin-Induced Diabetic Rats

Abstract

In this study, the effect of phytic acid supplement on streptozotocin-induced diabetic rats was investigated. Diabetic rats were fed rodent chow with or without phytic acid supplementation for thirty days. Blood and organ samples were collected for assays. The average food intake was the highest and the body weight gain was the lowest in the group fed phytic acid supplement compared to the diabetic and normal control groups. There was a downward trend in intestinal amylase activity in the group fed phytic acid supplement compared to the other groups. The spike in random blood glucose was the lowest in the same group. We noted reduced serum triglycerides and increased total cholesterol and HDL cholesterol levels in the group fed phytic acid supplement. Serum alkaline phosphatase and alanine amino transferase activities were significantly (P < 0.05) increased by phytic acid supplementation. Systemic IL-1β level was significantly (P < 0.05) elevated in the diabetic control and supplement treated groups. The liver lipogenic enzyme activities were not significantly altered among the groups. These results suggest that phytic acid supplementation may be beneficial in the management of diabetes mellitus. The observed adverse effect on the liver may be due to the combined effect of streptozotocin-induced diabetes and phytic acid supplementation.

Use of unripe plantain (Musa paradisiaca) in the management of diabetes and hepatic dysfunction in streptozotocin induced diabetes in rats

“…The decreased serum amylase activities of the diabetic control rats as observed in this study is attributed to the inhibition of STZ on Ca and Mg homeostasis and amylase gene expression [30] while the increased amylase activities of the nondiabetic rats may be related to fl uctuations in the rates of amylase synthesis and its secretion by secretory glands [31,32].…”

The effect of combined inositol hexakisphosphate and inositol supplement in streptozotocin‐induced type 2 diabetic rats

“…However, treatment with the combination significantly reduced serum total cholesterol and triglyceride levels compared with the diabetic control group. Omoruyi et al (2013) highlighted a positive association between decreased body weight and increased HDL in diabetic rats fed phytic acid. There were no significant changes observed in serum lipids in diabetic rats treated with glibenclamide compared with the untreated diabetic control group.…”

“…This may account for the observed reductions in serum cholesterol and triglyceride concentrations in these animals. Omoruyi et al (2013) highlighted a positive association between decreased body weight and increased HDL in diabetic rats fed phytic acid. It is however not known whether it is increased lipid uptake or increased utilization that may be affecting serum HDL in these animals.…”

“…Therefore, a positive response to this test suggests that a type 2 diabetic model was achieved. Previous research (Dilworth et al 2005;Lee et al 2006;Kuppusamy et al 2011;Omoruyi et al 2013) has demonstrated the hypoglycaemic effects of phytic acid alone in diabetic and non-diabetic rats. The data showed no significant difference in fasting serum insulin levels between the diabetic and non-diabetic groups, and this was reported to be characteristic of type 2 diabetes (Reed et al 2000).…”

“…However, the administration of the combination or glibenclamide to the diabetic rats significantly reduced insulin resistance to normal levels. Previous research (Dilworth et al 2005;Lee et al 2006;Kuppusamy et al 2011;Omoruyi et al 2013) has demonstrated the hypoglycaemic effects of phytic acid alone in diabetic and non-diabetic rats. In this study however, the main focus was on the treatment of type 2 diabetic rats with an IP6/inositol combination product that we theorized may be more effective than IP6 or inositol alone.…”