The potential cardioprotective effects of amifostine in irradiated rats

Tokatli, Füsun; Uzal, Cem; Doğanay, Latife; Koçak, Zafer; Kaya, Meryem; Türe, Mevlüt; Kürüm, Turhan; Alkaya, Fadime; Karadağ, Çetin Hakan; Kutlu, Kemal

doi:10.1016/j.ijrobp.2003.09.071

Cited by 33 publications

(51 citation statements)

References 39 publications

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“…Agents with evidence for cardiac efficacy include free radical scavengers, antioxidants, statins, steroids, natural products, and other agents (8,10,36,80,90). In the present discussion, this will be limited to compounds that are potentially available to act as pharmaceutical and nutraceutical medical countermeasures against radiation-induced injury to the heart.…”

Section: Baker Et Almentioning

confidence: 99%

“…The initial radiation exposure originated from > 40 different radionuclides, notably in the first 10 days after the accident. The most significant of these were iodine ( 131 I), caesium ( 137 Cs), and strontium (particularly 90 Sr). 131 I produces b-and g-ray emissions, 137 Cs produces grays, and 90 Sr produces b-emissions.…”

Section: Radiation Accidentsmentioning

confidence: 99%

“…The most significant of these were iodine ( 131 I), caesium ( 137 Cs), and strontium (particularly 90 Sr). 131 I produces b-and g-ray emissions, 137 Cs produces grays, and 90 Sr produces b-emissions. In 1986, the average dose to > 300,000 recovery workers, ''liquidators,'' was nearly 150 mSv, and > 350,000 other individuals received doses > 10 mSv (71a).…”

Section: Radiation Accidentsmentioning

confidence: 99%

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Radiation as a Risk Factor for Cardiovascular Disease

Baker

Moulder

Hopewell

2011

Antioxidants & Redox Signaling

108

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Humans are continually exposed to ionizing radiation from terrestrial sources. The two major contributors to radiation exposure of the U.S. population are ubiquitous background radiation and medical exposure of patients. From the early 1980s to 2006, the average dose per individual in the United States for all sources of radiation increased by a factor of 1.7-6.2 mSv, with this increase due to the growth of medical imaging procedures. Radiation can place individuals at an increased risk of developing cardiovascular disease. Excess risk of cardiovascular disease occurs a long time after exposure to lower doses of radiation as demonstrated in Japanese atomic bomb survivors. This review examines sources of radiation (atomic bombs, radiation accidents, radiological terrorism, cancer treatment, space exploration, radiosurgery for cardiac arrhythmia, and computed tomography) and the risk for developing cardiovascular disease. The evidence presented suggests an association between cardiovascular disease and exposure to low-to-moderate levels of radiation, as well as the well-known association at high doses. Studies are needed to define the extent that diagnostic and therapeutic radiation results in increased risk factors for cardiovascular disease, to understand the mechanisms involved, and to develop strategies to mitigate or treat radiation-induced cardiovascular disease. Antioxid. Redox Signal. 15, 1945Signal. 15, -1956

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Section: Baker Et Almentioning

confidence: 99%

Section: Radiation Accidentsmentioning

confidence: 99%

Section: Radiation Accidentsmentioning

confidence: 99%

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Radiation as a Risk Factor for Cardiovascular Disease

Baker

Moulder

Hopewell

2011

Antioxidants & Redox Signaling

108

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“…One of the characterized biological damages caused by ROS is their reaction with unsaturated lipids, known as lipid peroxidation (30). In their experimental study, Tokatlı et al (31) have used amifostine, a potential ROS scavenger that is currently in use in radiotherapy. At the 100 th day of irradiation, according to a myocardial degeneration grading, they observed a protective effect of amifostine on heart.…”

Section: Discussionmentioning

confidence: 99%

The effect of magnesium and vitamin E pre-treatments on irradiation-induced oxidative injury of cardiac and pulmonary tissues in rats: a randomized experimental study

Atasoy

Özgen²,

Bostancı³

et al. 2012

Anadolu Kardiyol Derg

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The effect of magnesium and vitamin E pre-treatments on irradiationinduced oxidative injury of cardiac and pulmonary tissues in rats: a randomized experimental studyProfilaktik magnezyum ve E vitamini uygulamasının sıçanlarda ışınlamaya bağlı kalp ve akciğer dokusunda gelişen oksidan hasara etkileri: Randomize deneysel bir çalışma ABSTRACTObjective: The aim of this study was to investigate the effect of pre-treatment with the free radical scavenging molecules, magnesium and vitamin E, on lipid peroxidation to limit radiation-induced heart and lung injury. Methods: Female Sprague-Dawley rats were divided into 4 groups by a simple randomization method as saline-treated control (n=4), salinetreated irradiated (IR; n=6), magnesium sulphate-treated irradiation (IR) (Mg+IR; n=6) and vitamin E-treated IR (vit E+IR; n=6), respectively. The animals were given either saline, Mg (600mg/kg/day) or vit E (100 mg/kg/day) intraperitoneally for five days prior to irradiation. Twelve hours after the fifth injection, animals in irradiation groups were irradiated to 20 Gy using 6 MV photons in linear accelerator. Twenty-four hours later cardiac and lung tissue samples were obtained for determination of myeloperoxidase activity (MPO), malondialdehyde (MDA) levels, and luminol and lucigenin levels measured by chemiluminescence (CL) methods. Results: No significant changes were observed between cardiac and pulmonary MDA and CL results of the experimental groups. However, cardiac and pulmonary MPO activities in the saline-treated IR group were increased as compared to control group (p<0.05 for all), while in the Mg-pretreated and vit E pretreated groups neutrophil infiltration was reduced, reaching to statistical significance only in the Mg-pretreated group (p<0.05). Conclusion: Prophylactic use of magnesium sulfate has limited the infiltration of neutrophils to both the cardiac and pulmonary tissues at the early 24 h of irradiation. However, how limiting neutrophils as the sources of free radicals and inflammatory mediators would alter oxidative stress of heart and lung tissues in the long-term is not clear yet. (Anadolu Kardiyol Derg 2012; 12: 508-14) Key words: Heart, irradiation, lung, magnesium, radioprotection, vitamin E Original Investigation Özgün Araşt›rma 508ÖZET Amaç: Serbest radikal süpürücü moleküller olan magnezyum sülfat ve E vitamininin profilaktik kullanımının radyasyonun tetiklediği kalp ve akciğer hasarının önlenmesinde lipit peroksidasyonu üzerindeki etkileri incelendi. Yöntemler: Sprague-Dawley türü dişi sıçanlar basit rastgele randomizasyon yöntemi kullanılarak fizyolojik tuzlu su uygulanan kontrol (n=4), tek başına radyasyon (IR; n=6), radyasyon+magnezyum (Mg+IR; n=6) ve radyasyon+vitamin E (vit E+IR; n=6) ön-tedavisine göre gruplandırıldı. Fizyolojik tuzlu su, Mg (600 mg/kg/gün) ya da vit E (100 mg/kg/gün) radyasyondan önce 5 gün boyunca intraperitonal olarak uygulandı. Son enjeksiyondan 20 saat sonra radyasyon uygulanacak tüm gruplardaki sıçanlara 6 MV foton enerjisi ile 20 Gy iyonizan radyasyon uygulandı. ...

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“…Additionally, amifostine may also act as a radioprotector by its direct actions on cells by arresting the cell cycle at G1 phase and inducing p21 expression (6). There are few articles in literature investigating the protective effect of amifostine on RIHD (7,8).…”

Section: Introductionmentioning

confidence: 99%

Histopathological efficiency of amifostine in radiation‑induced heart disease in rats

Gürses¹,

Özeren²,

Serin³

et al. 2018

BLL

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OBJECTIVE: Amifositine is a phosphorylated thiol that holds its radioprotective actions by several indirect mechanisms. The purpose of this study was to evaluate histopathologically whether amifositine administration prior to irradiation would have a long-term protective effect on heart tissue in an experimental rat model. METHODS: Single dose of 18 Gy radiation and sham radiation exposure were used in related groups. A dose of 200 mg/kg of amifostine was injected intraperitoneally 30 min prior to radiation exposure. Analyses were performed 6 months after irradiation. RESULTS: Vascular damage and vasculitis were signifi cantly decreased in amifositine treatment group. At the same time, signifi cant thickening of the medial layer was accompanied by vascular damage in irradiated groups. The number and severity of myocyte necrosis were diminished with amifostine. Nevertheless, it could not prevent epicardial and myocardial fi brosis. Severe myocardial fi brosis was observed prominently in three regions, particularly on the apex, tips of papillary muscles and in sites adjacent to the atrioventricular valves. The anti-infl ammatory effect of amifostine was not seen. CONCLUSION: The development of vascular damage and vasculitis were prevented by the use of amifostine. There was a correlation between vascular damage and fi brosis development. According to histopathological results, amifostine could be used as a protective agent against the side effects of radiotherapy (Tab. 4, Fig. 2, Ref. 22). Text in PDF www.elis.sk.

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The potential cardioprotective effects of amifostine in irradiated rats

Cited by 33 publications

References 39 publications

Radiation as a Risk Factor for Cardiovascular Disease

Radiation as a Risk Factor for Cardiovascular Disease

The effect of magnesium and vitamin E pre-treatments on irradiation-induced oxidative injury of cardiac and pulmonary tissues in rats: a randomized experimental study

Histopathological efficiency of amifostine in radiation‑induced heart disease in rats

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