The potential etiopathogenetic role and diagnostic utility of CD3<sup>+</sup>CD56<sup>+</sup> regulatory T lymphocytes in Myelodysplastic Syndromes

Rubino, Valentina; Leone, Stefania; Carriero, Flavia; Pane, Fabrizio; Ruggiero, Giuseppina; Terrazzano, Giuseppe

doi:10.1111/ejh.13931

Cited by 4 publications

(7 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Such evidence suggests that T R3-56 cells may play a role in regulating the activity of cytotoxic T cells in the bone marrow. Furthermore, the study showed that T R3-56 cells from MDS patients exhibited a regulatory phenotype and were capable of suppressing the proliferation and activation of cytotoxic T cells [112,113]. This indicates that T R3-56 cells may have immunosuppressive functions in the bone marrow microenvironment, as we previously described for Tregs [114].…”

Section: A New Cell Candidate For Immune Regulation: the T R3-56supporting

confidence: 62%

“…MDS comprises a group of blood disorders characterized by ineffective hematopoiesis and a consistent risk of leukemia evolution [112]. We found that in patients with very-low-risk/low-risk MDS, there was an inverse association between the number of T R3-56 cells and the activation and expansion of bone marrow cytotoxic T cells [112,113]. Such evidence suggests that T R3-56 cells may play a role in regulating the activity of cytotoxic T cells in the bone marrow.…”

Section: A New Cell Candidate For Immune Regulation: the T R3-56mentioning

confidence: 90%

“…In addition, we investigated the role of bone marrow T R3-56 cells in patients with verylow-risk/low-risk myelodysplastic syndrome (MDS) [112,113] according to the Revised International Prognostic Scoring System (IPSS-R) [112,113]. MDS comprises a group of blood disorders characterized by ineffective hematopoiesis and a consistent risk of leukemia evolution [112].…”

Section: A New Cell Candidate For Immune Regulation: the T R3-56mentioning

confidence: 99%

“…Indeed, the imbalance between T R3-56 cells and cytotoxic T cells in the bone marrow of very-low-risk/low-risk MDS patients may contribute to the immune-mediated elimination of healthy hematopoiesis, affecting MDS pathogenesis. On the other hand, an increased number and activity of T R3-56 cells could contribute to the generation of an immune-suppressed microenvironment in high-risk MDS, which may contribute to the progression of acute leukemia [112,113].…”

Section: A New Cell Candidate For Immune Regulation: the T R3-56mentioning

confidence: 99%

“…However, a more extensive phenotypic and functional characterization of all the lymphocyte subtypes co-expressing CD3 and CD56 represents the only approach to determining their role and possible involvement in effector and/or immune regulation mechanisms. In this regard, our original and pioneering research on T R3-56 cells in the TD1, MDS, and CLL models revealed the phenotypic and functional characteris-tics of this distinct subpopulation of CD3+ CD56+ T cells, highlighting its distinctiveness in immunoregulation [111][112][113][114].…”

Section: Previous Observations On Cd3+cd56+ Co-expressing T Cells In ...mentioning

confidence: 99%

See 4 more Smart Citations

Regulatory TR3-56 Cells in the Complex Panorama of Immune Activation and Regulation

Carriero,

Rubino,

Leone

et al. 2023

Cells

Self Cite

View full text Add to dashboard Cite

The interplay between immune activation and immune regulation is a fundamental aspect of the functional harmony of the immune system. This delicate balance is essential to triggering correct and effective immune responses against pathogens while preventing excessive inflammation and the immunopathogenic mechanisms of autoimmunity. The knowledge of all the mechanisms involved in immune regulation is not yet definitive, and, probably, the overall picture is much broader than what has been described in the scientific literature so far. Given the plasticity of the immune system and the diversity of organisms, it is highly probable that numerous other cells and molecules are still to be ascribed to the immune regulation process. Here, we report a general overview of how immune activation and regulation interact, based on the involvement of molecules and cells specifically dedicated to these processes. In addition, we discuss the role of TR3-56 lymphocytes as a new cellular candidate in the immune regulation landscape.

show abstract

Section: A New Cell Candidate For Immune Regulation: the T R3-56supporting

confidence: 62%

Section: A New Cell Candidate For Immune Regulation: the T R3-56mentioning

confidence: 90%

Section: A New Cell Candidate For Immune Regulation: the T R3-56mentioning

confidence: 99%

Section: A New Cell Candidate For Immune Regulation: the T R3-56mentioning

confidence: 99%

Section: Previous Observations On Cd3+cd56+ Co-expressing T Cells In ...mentioning

confidence: 99%

See 3 more Smart Citations

Regulatory TR3-56 Cells in the Complex Panorama of Immune Activation and Regulation

Carriero,

Rubino,

Leone

et al. 2023

Cells

Self Cite

View full text Add to dashboard Cite

show abstract

Adaptive and Innate Cytotoxic Effectors in Chronic Lymphocytic Leukaemia (CLL) Subjects with Stable Disease

Rubino,

Carriero,

Palatucci

et al. 2023

IJMS

Self Cite

View full text Add to dashboard Cite

Chronic lymphocytic leukaemia (CLL) is characterised by the expansion of a neoplastic mature B cell clone. CLL clinical outcome is very heterogeneous, with some subjects never requiring therapy and some showing an aggressive disease. Genetic and epigenetic alterations and pro-inflammatory microenvironment influence CLL progression and prognosis. The involvement of immune-mediated mechanisms in CLL control needs to be investigated. We analyse the activation profile of innate and adaptive cytotoxic immune effectors in a cohort of 26 CLL patients with stable disease, as key elements for immune-mediated control of cancer progression. We observed an increase in CD54 expression and interferon (IFN)-γ production by cytotoxic T cells (CTL). CTL ability to recognise tumour-targets depends on human leukocyte antigens (HLA)-class I expression. We observed a decreased expression of HLA-A and HLA-BC on B cells of CLL subjects, associated with a significant reduction in intracellular calnexin that is relevant for HLA surface expression. Natural killer (NK) cells and CTL from CLL subjects show an increased expression of the activating receptor KIR2DS2 and a reduction of 3DL1 and NKG2A inhibiting molecules. Therefore, an activation profile characterises CTL and NK cells of CLL subjects with stable disease. This profile is conceivable with the functional involvement of cytotoxic effectors in CLL control.

show abstract

Immune Profile in COVID-19: Unveiling TR3-56 Cells in SARS-CoV-2 Infection

Carriero,

Rubino,

Gelzo

et al. 2024

IJMS

View full text Add to dashboard Cite

The emergence of COronaVIrus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), presented a global health challenge since its identification in December 2019. With clinical manifestations ranging from mild respiratory symptoms to severe multi-organ dysfunction, COVID-19 continues to affect populations worldwide. The complex interactions between SARS-CoV-2 variants and the human immune system are crucial for developing effective therapies, vaccines, and preventive measures. Understanding these immune responses highlights the intricate nature of COVID-19 pathogenesis. This retrospective study analyzed, by flow cytometry approach, a cohort of patients infected with SARS-CoV-2 during the initial pandemic waves from 2020 to 2021. It focused on untreated individuals at the time of hospital admission and examined the presence of TR3-56 cells in their immune profiles during the anti-viral immune response. Our findings provide additional insights into the complex immunological dynamics of SARS-CoV-2 infection and highlight the potential role of TR3-56 cells as crucial components of the immune response. We suggest that TR3-56 cells could serve as valuable biomarkers for identifying more severe cases of COVID-19, aiding in the assessment and management of the disease.

show abstract

The potential etiopathogenetic role and diagnostic utility of CD3⁺CD56⁺ regulatory T lymphocytes in Myelodysplastic Syndromes

Cited by 4 publications

References 8 publications

Regulatory TR3-56 Cells in the Complex Panorama of Immune Activation and Regulation

Regulatory TR3-56 Cells in the Complex Panorama of Immune Activation and Regulation

Adaptive and Innate Cytotoxic Effectors in Chronic Lymphocytic Leukaemia (CLL) Subjects with Stable Disease

Immune Profile in COVID-19: Unveiling TR3-56 Cells in SARS-CoV-2 Infection

Contact Info

Product

Resources

About

The potential etiopathogenetic role and diagnostic utility of CD3+CD56+ regulatory T lymphocytes in Myelodysplastic Syndromes

Cited by 4 publications

References 8 publications

Regulatory TR3-56 Cells in the Complex Panorama of Immune Activation and Regulation

Regulatory TR3-56 Cells in the Complex Panorama of Immune Activation and Regulation

Adaptive and Innate Cytotoxic Effectors in Chronic Lymphocytic Leukaemia (CLL) Subjects with Stable Disease

Immune Profile in COVID-19: Unveiling TR3-56 Cells in SARS-CoV-2 Infection

Contact Info

Product

Resources

About

The potential etiopathogenetic role and diagnostic utility of CD3⁺CD56⁺ regulatory T lymphocytes in Myelodysplastic Syndromes