The potential for clinical application of automatic quantification of olfactory bulb volume in MRI scans using convolutional neural networks

Postma, Elbrich M.; Noothout, Julia M. H.; Boek, Wilbert M.; Joshi, Akshita; Herrmann, Theresa; Hummel, Thomas; Smeets, Paul A.M.; Išgum, Ivana; Boesveldt, Sanne

doi:10.1016/j.nicl.2023.103411

NeuroImage: Clinical

2023

DOI: 10.1016/j.nicl.2023.103411

|View full text |Cite

The potential for clinical application of automatic quantification of olfactory bulb volume in MRI scans using convolutional neural networks

Elbrich M. Postma

Julia M. H. Noothout

Wilbert M. Boek

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Clinical significance of MRI-measured olfactory bulb height as an imaging biomarker of idiopathic Parkinson’s disease

Park,

Lee,

Kim

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

Objectives This study aimed to determine whether the olfactory bulb height (OBH) measured using magnetic resonance imaging (MRI) has clinical utility as an imaging biomarker in the evaluation of patients with idiopathic Parkinson’s disease (iPD) through its correlation with movement impairment. Methods This retrospective study included cognitively intact patients with suspected parkinsonism. All participants underwent T2-weighted imaging to measure OBH. Logistic regression was used to determine whether OBH was an independent risk factor for distinguishing iPD patients from disease controls, and its relation with clinical parameters related to motor impairment, including clinical laterality, modified Hoehn and Yahr (HY) stage, and Unified Parkinson’s Disease Rating Scale (UPDRS) III score, was investigated. Results Based on the final clinical diagnosis, 79 patients with iPD and 16 disease controls were included. The mean OBH was significantly smaller in iPD than in disease controls (p < 0.0001). OBH was a significant independent predictor of iPD, with a cutoff of 1.52 mm. In the comparison among the ipsilateral, contralateral side of iPD with clinical laterality, and disease control group, the OBH of the disease control group was significantly larger than both the ipsilateral and contralateral sides (P < 0.05). However, there was no significant difference in OBH between the ipsilateral and contralateral sides (p > 0.05). OBH according to HY stage was significantly smaller in HY stage 2–3 groups than in the disease control group (p < 0.001). The correlation analysis between UPDRS III and OBH showed a mild negative correlation (r = -0.32, p = 0.013). Conclusions MRI-measured OBH is decreased in iPD regardless of age and sex and may be correlated with the progression of motor symptoms in the iPD.

show abstract

Clinical significance of MRI-measured olfactory bulb height as an imaging biomarker of idiopathic Parkinson’s disease

Park,

Lee,

Kim

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

show abstract

Preliminary Findings on the Morphometric Characteristics of the Olfactory Bulb in the Cat

Alvites,

Caine,

Cherubini

et al. 2024

Animals

View full text Add to dashboard Cite

The aim of this preliminary study was to morphologically and dimensionally characterize the cat’s olfactory bulb in the sagittal plane and to establish potential relationships with the cranial conformation, based on the study of in vivo MRI images. Midsagittal and transverse T2-weighted images of the head of 40 cats subjected to MRI were selected. For each animal, the skull index was calculated to classify the cranial conformation. Then, for the olfactory bulb, the angle was calculated, the orientation was determined, and the sagittal section area was measured. It was established that animals classified as brachycephalic have more compact olfactory bulbs, with smaller cross-sectional areas, ventral orientation and smaller angles established with the line that goes from the hard palate and the intercondylar notch of the foramen magnum. Animals classified as dolichocephalic have more globose and wider olfactory bulbs, dorsal orientation, and larger angles. Mesocephalic animals present an intermediate position. Males and younger adult animals have olfactory bulbs with larger cross-sectional areas than females and older animals. This work allows for the preliminarily characterization of the olfactory bulb in cats in the sagittal plane, and the correlations identified with other head structures open doors for the use of the bulb as an early indicator for the establishment of alterations of varied etiology.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

The potential for clinical application of automatic quantification of olfactory bulb volume in MRI scans using convolutional neural networks

Cited by 2 publications

References 49 publications

Clinical significance of MRI-measured olfactory bulb height as an imaging biomarker of idiopathic Parkinson’s disease

Clinical significance of MRI-measured olfactory bulb height as an imaging biomarker of idiopathic Parkinson’s disease

Preliminary Findings on the Morphometric Characteristics of the Olfactory Bulb in the Cat

Contact Info

Product

Resources

About