The potential health risk of titania nanoparticles

Sequential assessment via daphnia and zebrafish for systematic toxicity screening of heterogeneous substances

“…To evaluate the combined toxicities of mixtures with various combination of UV-filters rather than a single UV-filter, two different types of UV-filters, ethylhexyl methoxycinnamate (EHMC) (UVA protection) (Christen et al, 2011;Kaiser et al, 2012a;Sieratowicz et al, 2011) and Benzophenone-3 (BP-3) (UVB protection) Sieratowicz et al, 2011), were chosen based on their toxicities to aquatic organisms. To better understand the interaction between toxic-and non-toxic substances in a mixture, titanium dioxide nanoparticles (TiO 2 NPs) was also chosen in this study, due to the reports that there was no noticeable toxicity of TiO 2 NPs (George et al, 2014;Marcone et al, 2012;Pavagadhi et al, 2014;Strigul et al, 2009;Zhang et al, 2012;Zhu et al, 2010) to aquatic organisms such as Vibrio fischeri, Daphnia magna, and zebrafish embryo (approximately up to 10 mg/L).…”

Biomarker analysis for nanotoxicology

“…There are protein oxidation assays that test for protein carbonyls, various tyrosine products, and methionine sulfoxidation. Lastly, there are antioxidant assays that will quantify the levels of ascorbic acid, tocopherols, GSH, GSSG, uric acid, and total antioxidant capacity (TAC) (Zhang et al, 2012). All of the stated biomolecules above are biomarkers for various metal oxide nanoparticle species (Hyeon et al, 2012).…”

Biomedical Nanoparticles: Overview of Their Surface Immune-Compatibility

“…For this reason, they are commonly used for cosmetics or sunscreens preparations as an efficient filter of UV light [82]. In contrast, other studies reported cell toxicity and genotoxicity [83][84][85]. The discrepancy may be due to different TiO 2 particle compositions, different cellular origin, or variation in TiO 2 sensitivity between the organisms.…”