The Potential Impact of Maternal Milk Consumption During Pregnancy on mTORC1-Driven Fetal Growth

Melnik, Bodo C.

doi:10.1007/978-3-319-14874-8_18

Cited by 2 publications

(2 citation statements)

References 193 publications

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“…This association appeared to be limited only to milk, whereas protein intake from non-dairy food or cheese was not associated with an increase in birth weight [96]. A systematic review of all studies and case reports supported the conclusion that only milk consumption but not the intake of fermented milk/milk products increased birth weight [97,98]. Thus, some compounds of unfermented milk not related to milk proteins, accelerate fetal growth.…”

Section: Fetal Macrosomiamentioning

confidence: 83%

Exosomes of pasteurized milk: potential pathogens of Western diseases

Melnik

Schmitz

2019

J Transl Med

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Milk consumption is a hallmark of western diet. According to common believes, milk consumption has beneficial effects for human health. Pasteurization of cow's milk protects thermolabile vitamins and other organic compounds including bioactive and bioavailable exosomes and extracellular vesicles in the range of 40-120 nm, which are pivotal mediators of cell communication via systemic transfer of specific micro-ribonucleic acids, mRNAs and regulatory proteins such as transforming growth factor-β. There is compelling evidence that human and bovine milk exosomes play a crucial role for adequate metabolic and immunological programming of the newborn infant at the beginning of extrauterine life. Milk exosomes assist in executing an anabolic, growth-promoting and immunological program confined to the postnatal period in all mammals. However, epidemiological and translational evidence presented in this review indicates that continuous exposure of humans to exosomes of pasteurized milk may confer a substantial risk for the development of chronic diseases of civilization including obesity, type 2 diabetes mellitus, osteoporosis, common cancers (prostate, breast, liver, B-cells) as well as Parkinson's disease. Exosomes of pasteurized milk may represent new pathogens that should not reach the human food chain.

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Section: Fetal Macrosomiamentioning

confidence: 83%

Exosomes of pasteurized milk: potential pathogens of Western diseases

Melnik

Schmitz

2019

J Transl Med

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“…Remarkably, cow’s milk consumption by humans during pregnancy, but not the intake of fermented milk products, increase birthweight [ 234 , 235 ], which underlines the mTORC1-activating and growth promoting effects of MEX. Thus, high milk consumption during pregnancy promotes mTORC1-driven fetal overgrowth [ 248 ]. In accordance, cafeteria and high-fat diets in nursing rats and mice modifies specific miR levels in milk [ 249 , 250 ].…”

Section: Milk-induced Overactivation Of Mtorc1 and Diseases Of CIVmentioning

confidence: 99%

Lifetime Impact of Cow’s Milk on Overactivation of mTORC1: From Fetal to Childhood Overgrowth, Acne, Diabetes, Cancers, and Neurodegeneration

Melnik

2021

Biomolecules

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The consumption of cow’s milk is a part of the basic nutritional habits of Western industrialized countries. Recent epidemiological studies associate the intake of cow’s milk with an increased risk of diseases, which are associated with overactivated mechanistic target of rapamycin complex 1 (mTORC1) signaling. This review presents current epidemiological and translational evidence linking milk consumption to the regulation of mTORC1, the master-switch for eukaryotic cell growth. Epidemiological studies confirm a correlation between cow’s milk consumption and birthweight, body mass index, onset of menarche, linear growth during childhood, acne vulgaris, type 2 diabetes mellitus, prostate cancer, breast cancer, hepatocellular carcinoma, diffuse large B-cell lymphoma, neurodegenerative diseases, and all-cause mortality. Thus, long-term persistent consumption of cow’s milk increases the risk of mTORC1-driven diseases of civilization. Milk is a highly conserved, lactation genome-controlled signaling system that functions as a maternal-neonatal relay for optimized species-specific activation of mTORC1, the nexus for regulation of eukaryotic cell growth, and control of autophagy. A deeper understanding of milk´s impact on mTORC1 signaling is of critical importance for the prevention of common diseases of civilization.

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The Potential Impact of Maternal Milk Consumption During Pregnancy on mTORC1-Driven Fetal Growth

Cited by 2 publications

References 193 publications

Exosomes of pasteurized milk: potential pathogens of Western diseases

Exosomes of pasteurized milk: potential pathogens of Western diseases

Lifetime Impact of Cow’s Milk on Overactivation of mTORC1: From Fetal to Childhood Overgrowth, Acne, Diabetes, Cancers, and Neurodegeneration

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