The potential of carcinoembryonic antigen, p53, Ki-67 and glutathion Stransferase-π as clinico-histopathological markers for colorectal cancer

Abstract

ObjectiveColorectal cancer is one of the major contributors to cancer death worldwide. Lack of reliable colorectal cancer markers has hampered the management of these cancer patients. Our main purpose was to study the correlation between histopathological variables of colorectal adenocarcinomas and identify histopathological markers that are of prognostic value in patients with colorectal cancer.MethodsIn the present study, we examined the expression of carcinoembryonic antigen (CEA), p53, Ki-67 and glutathion Stransferase (GST) -π by using immunohistochemical staining methods in 126 colorectal carcinoma patients and evaluated the lymph node metastasis status in these patients by histopathological examination.ResultsThe positive rates of CEA, p53, Ki-67 and GST-π expression in the colorectal cancer tissue specimens examined were 95.23%, 55.56%, 53.38% and 82.30%, respectively. Expression of p53 and Ki-67 was significantly correlated with the Dukes stages of the tumor, with higher levels of these proteins in Dukes'C and D tumors than those in Dukes' A and B tumors. Furthermore, the expression of p53, GST-π and Ki-67 correlated with prognosis of patients with colorectal cancer. Additionally, the expression of p53 in colorectal cancer was closely related to the expression of Ki-67 and the expression of GST-π was directly correlated with that of p53.ConclusionThe expression of CEA, p53, Ki-67 and GST-π was correlated with various clinical features of patients with colorectal cancer. The combined use of these histopathological markers appeared to be a promising tool in predicting the prognosis of patients with this type of cancer.

Correlation of Ki-67 proliferation index and 18-fluorodeoxyglucose uptake in colorectal incidental lesions detected by positron emission tomography-computed tomography

“…Higher proliferation indexes have shown to be related to worse outcome in colorectal carcinoma in several studies (8,9). We have demonstrated significant correlation between SUVmax and Ki-67 in colorectal neoplasms.…”

Colorectal carcinoma: nucleosomes, carcinoembryonic antigen and ca 19-9 as apoptotic markers; a comparative study

“…It was reported that the over expression of CEA can protect cancer cells from apoptosis while a decrease in expression might lead to new approaches for management of cancer colon and other organs [ 21 ]. CEA is produced by more than 90% of colorectal cancers and contributes to the malignant characteristics of this type of cancer [ 22 ].…”

“…Bhatnagar et al [ 32 ] noticed that in the well differentiated colorectal carcinoma there is more production of CEA/gram of total protein than in the poorly differentiated tumors in agreement with results obtained in the present study. On the other hand, it was observed that there is no significant correlation between levels of serum CA 19-9 and CEA [ 22 ] and the differentiation degree of the tumor.…”

Primary hepatic neuroendocrine tumors

“…Based on WHO digestive system classification, [19] neuroendocrine tumors were classified into three categories, which are G1: mitotic < 2/10 HPF and/or PI < 2%; G2: mitotic < 2-20) / 10 HPF and/or PI < 3% to 20%; Neuroendocrine carcinoma (NEC): mitosis > 20/10 HPF and/or Ki-67 PI > 20%. There are studies [20] demonstrating that mitosis, nuclear grading and Ki-67 PI are of great value for the evaluation of the malignancy and prognosis of PHNEN.…”