The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases

Maher, Pamela

doi:10.3390/ijms20123056

Cited by 179 publications

(118 citation statements)

References 115 publications

(153 reference statements)

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“…In the case of AD, their efficacy is attributed to the reduction of Aβ toxicity and decreasing oxidative stress [22,23]. Nevertheless, anti-AD effects of certain flavonoids, such as myricetin, rutin, fisetin, catechins, quercetin, kaempferol, and apigenin have been reported [24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Effects of Quercetin in Alzheimer’s Disease

et al. 2019

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Quercetin is a flavonoid with notable pharmacological effects and promising therapeutic potential. It is widely distributed among plants and found commonly in daily diets predominantly in fruits and vegetables. Neuroprotection by quercetin has been reported in several in vitro studies. It has been shown to protect neurons from oxidative damage while reducing lipid peroxidation. In addition to its antioxidant properties, it inhibits the fibril formation of amyloid-β proteins, counteracting cell lyses and inflammatory cascade pathways. In this review, we provide a synopsis of the recent literature exploring the relationship between quercetin and cognitive performance in Alzheimer’s disease and its potential as a lead compound in clinical applications.

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Section: Introductionmentioning

confidence: 99%

Neuroprotective Effects of Quercetin in Alzheimer’s Disease

et al. 2019

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“…There is scientific evidence that the overproduction of reactive oxygen species (ROS) in cells of the body beyond those needed for the effectiveness of the antioxidant defense system may cause damage to such biomolecules as lipids, proteins and DNA, and as a consequence may lead to various degenerative diseases, including cancer, diabetes mellitus, cardiovascular disease, hypertension, rheumatoid diseases, arthritis and neurodegenerative diseases [1][2][3]. The consumption of antioxidants in food and dietary supplements has been linked to a reduced risk of these diseases [4,5]. Antioxidants also play an important role in extending the shelf life of food [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Sunflower (Helianthus annuus L.) Plants at Various Growth Stages Subjected to Extraction—Comparison of the Antioxidant Activity and Phenolic Profile

et al. 2020

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The aim of this study was to evaluate the differences in the antioxidant activity and phenolic profile of sunflower (Helianthus annuus L.) extracts obtained from the aerial parts of plants harvested at five growth stages. In vitro assays were used to determine the antioxidant activity, i.e., ABTS•+ and DPPH• scavenging activity, the ferric-reducing antioxidant power (FRAP) and the ability to inhibit β-carotene–linoleic acid emulsion oxidation. Phenolic compounds, such as mono- and dicaffeoylquinic acid isomers and caffeic acid hexose, were identified using the LC–TOF–MS/MS technique. The predominant compound during the growth cycle of the plant was 3,5-di-O-caffeoylquinic acid, whose content was the highest at the mid-flowering stage. The total phenolic content was also the highest in sunflowers at the mid-flowering stage. The main phenolic compound contents were closely correlated with ABTS•+ and DPPH• scavenging activity and FRAP. No significant correlation was found between the total phenolic content and the antioxidant activity in the emulsion system. The highest antiradical activity and FRAP were generally determined in older plants (mid-flowering and late flowering stages). In conclusion, the aerial parts of sunflowers, in particular those harvested at the mid-flowering stage, are a good plant material from which to obtain phenolic compound extracts, albeit mainly of one class (esters of caffeic acid and quinic acid), with high antioxidant activity.

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“…A substantial body of the literature has reported the multitude pharmacological applications of plant extracts and the compounds isolated from plant extracts [7]. Harnessing the biological potential of medicinal plants represents a sterling opportunity for the development of novel therapeutic candidates [8,9]. e bioactive plant extracts are a promising source of many drugs.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Analysis and Antimicrobial/Antioxidant Activity ofCynodon dactylon(L.) Pers. Rhizome Methanolic Extract

Savadi

Vazifedoost

Didar

et al. 2020

Journal of Food Quality

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A proper use of medicinal plants requires accurate scientific information and understanding of their chemical constituents. The therapeutic effects in the plants are due to the chemical compounds therein. Cynodon dactylon (L.) Pers. of the family Poaceae is a perennial, pan-tropical species of grass which is a well-known traditional medicine and has a renowned position for treatment of many symptoms and diseases. The chemical composition, free radical scavenging activity, and antimicrobial properties of the methanolic extract of C. dactylon rhizomes against selected bacterial and fungal strains were investigated using disk-diffusion method. The results indicated that the major fatty acid structures of C. dactylon methanolic extract were palmitic acid (36.40%), oleic acid (28.26%), and linoleic acid (17.01%). Alpha-tocopherol (151.39 mg·kg−1) and sitosterol (3199.62 mg·kg−1) were the main tocopherols and sterols, respectively. According to the instrumental analysis, the total phenolic compounds of methanolic extract were equal to 917.08 mg·kg−1 and the main compound was hydroquinone (66.89%). Antioxidant activity of the methanolic extract at concentrations of 100–1000 ppm was 9.81–67.87%, which is significantly different from the 200 ppm synthetic antioxidant (BHT) with free radical scavenging activity equal to 48.93% (p<0.05). The antimicrobial study revealed that the methanolic extract of C. dactylon rhizomes was effective against all of the bacterial pathogens and the antibacterial activity increased with an increase in the concentration of extract. Therefore, the largest zone of inhibition was observed against Bacillus cereus (18.3 ± 0.4 mm) and Escherichia coli (16.8 ± 0.5 mm) at 1000 ppm. The highest resistance was observed with Pseudomonas aeruginosa (inhibition zone of 12.8 ± 0.15 mm). Methanolic extract at 200 ppm had no effect against fungus Aspergillus niger. However, at 1000 ppm concentration, an inhibition zone with a diameter of 14.4 ± 0.45 mm was formed.

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The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases

Cited by 179 publications

References 115 publications

Neuroprotective Effects of Quercetin in Alzheimer’s Disease

Neuroprotective Effects of Quercetin in Alzheimer’s Disease

Sunflower (Helianthus annuus L.) Plants at Various Growth Stages Subjected to Extraction—Comparison of the Antioxidant Activity and Phenolic Profile

Phytochemical Analysis and Antimicrobial/Antioxidant Activity ofCynodon dactylon(L.) Pers. Rhizome Methanolic Extract

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