The potential of flow-through optosensors in pharmaceutical analysis

“…However, the implementation of Solid Phase Spectroscopy (SPS) [27] in flow systems, called flow-through optosensing [28], improves both the selectivity and sensitivity of the MCFIA systems. In these optosensors, the separation (matrix removal) and retention of the species of interest on the solid phase takes place in the detection area itself and simultaneously with it.…”

Section: Multicommutated Flow Analysismentioning

confidence: 99%

Multicommutation in Flow Systems: A Useful Tool for Pharmaceutical and Clinical Analysis

Llorent‐Martínez¹,

Barrales²,

Córdova³

et al. 2010

CPA

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Multicommutation is a methodology of increasing use for the development of chemical analysis systems. Specifically, it refers to continuous-flow configurations designed with computer-controlled commutators. The flow system, based on the implementation of solenoid valves in Flow Injection Analysis (FIA), is called Multicommutated Flow System (MCFIA). These flow systems can be easily re-configured by just changing the procedure with the software, resulting in increased versatility, potential for automation and minimization of both reagent consumption and waste generation. The use of solenoid pumps for propelling the solutions has been recently introduced and is known as Multipumping Flow Systems (MPFS). Finally, Multisyringe Flow Injection Analysis (MSFIA) has been developed implementing multicommutation principles in a modified Sequential Injection Analysis (SIA) system. This review covers a brief description about the fundamentals of the above mentioned methodologies as well as their application to pharmaceutical and clinical analysis. Several examples are given and some particular aspects are highlighted, such as the differences between measuring the analytical signal in solution or on a solid support (flow-through optosensor), a detailed classification of the reported methods in terms of the flow technique employed, or the novelty of each published method.

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“…The sample plug is inserted in the stream and the radiation directly interacts with the solid surface integrated in the detection area. This principle is called flow-through optosensors (FTOs) (3,4). When an FTO is put in direct contact with the (untreated) sample, it responds selectively to the species of interest, providing a reversible, rapid, and continuous response that is transduced via a nondestructive (molecular) spectroscopic detector.…”

Section: Introductionmentioning

confidence: 99%

Contribution to Automation for Determination of Drugs Based on Flow-Through Optosensors

Llorent‐Martínez

Ortega‐Barrales

Córdova

et al. 2011

Applied Spectroscopy Reviews

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The contribution of solid-phase spectroscopy (SPS) from its first conception (batch mode) to developments based on implementing SPS with flow analysis methodologies, flow-through optosensors (FTOs), is discussed. This article reviews the technical status of these sensors and addresses works of different flow technologies for the detection of drugs in pharmaceutical and clinical samples. In order to give readers insight into the features and the potential of FTO, relevant examples of strategies and typesof configuration are studied. The reports cited show the characteristics of these systems, including high sensitivity and selectivity, easy automation, less amount of reagent used, and low cost of the equipment. Finally, the advantages and disadvantages of the different flow methodologies described as well as a comparison with chromatographic techniques are critically highlighted.

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The potential of flow-through optosensors in pharmaceutical analysis

Cited by 41 publications

References 43 publications

A single spectroscopic flow-through sensing device for determination of ciprofloxacin

A single spectroscopic flow-through sensing device for determination of ciprofloxacin

Multicommutation in Flow Systems: A Useful Tool for Pharmaceutical and Clinical Analysis

Contribution to Automation for Determination of Drugs Based on Flow-Through Optosensors

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