The potential of <i>Epimedium koreanum</i> Nakai for herb–drug interaction

Zhong, Qing-Xiang; Shi, Zi-Qi; Zhang, Li; Zhong, Rongling; Xia, Zhi; Wang, Jing; Wu, Hao; Jiang, Yutong; Sun, E; Wei, Yingjie; Feng, Liang; Zhang, Zhenhai; Liu, Dan; Song, Jie; Jia, Xiao‐Bin

doi:10.1111/jphp.12773

Cited by 7 publications

(1 citation statement)

References 35 publications

(39 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It primarily spreads in Eastern Asia, with notable distribution in China, Korea, and Japan ( Lee et al., 2016 ; Qian et al., 2023 ). While the published papers on E. koreanum have mainly focused on recourse protection and sustainable utilization, including resource collection, cultivation, geographical distribution characteristics, and medical and pharmaceutical applications of its metabolites ( Zhong et al., 2017 ; Zhang et al., 2020 ), and there have been few investigations on its plant physiology and molecular characteristics. ( Lee et al., 2016 ).…”

Section: Introductionmentioning

confidence: 99%

DNA barcoding and comparative RNA-Seq analysis provide new insights into leaf formation using a novel resource of high-yielding Epimedium koreanum

Yang,

Fan,

Guo

et al. 2023

Front. Plant Sci.

View full text Add to dashboard Cite

Epimedium koreanum Nakai, a well-known traditional Chinese medicinal herb, has been widely used to treat osteoporosis and sexual dysfunction for thousands of years. However, due to the decreasing population of East Asian natural resources, yearly output of Epimedium crude herb has been in low supply year by year. In this study, an unusual variety of E. koreanum was discovered in Dunhua, Jilin Province, the northernmost area where this variety was found containing 6 individuals, with three branches that had 27 leaflets, which is much more than the typical leaflet number of 9. Firstly, the novel E. koreanum varety was identified using DNA barcodes. Then, 1171 differentially expressed genes (DEGs) were discovered through parallel RNA-seq analysis between the newly discovered variety and wild type (WT) E. koreanum plant. Furthermore, the results of bioinformatics investigation revealed that 914 positively and 619 negatively correlated genes associated with the number of leaflets. Additionally, based on RNA-Seq and qRT-PCR analysis, two homologous hub TCP genes, which were commonly implicated in plant leaf development, and shown to be up regulated and down regulated in the discovered newly variety, respectively. Thus, our study discovered a novel wild resource for leaf yield rewarding medicinal Epimedium plant breeding, provided insights into the relationship between plant compound leaf formation and gene expression of TCPs transcription factors and other gene candidates, providing bases for creating high yield cultivated Epimedium variety by using further molecular selection and breeding techniques in the future.

show abstract