The Potential of Indonesian Heterobranchs Found around Bunaken Island for the Production of Bioactive Compounds

Fisch, Katja M.; Hertzer, Cora; Böhringer, Nils; Wuisan, Zerlina G.; Schillo, Dorothee; Bara, Robert; Kaligis, Fontje; Wägele, Heike; König, Gabriele M.; Schäberle, Till F.

doi:10.3390/md15120384

Cited by 29 publications

(29 citation statements)

References 195 publications

(233 reference statements)

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“…Many of these compounds found in heterobranchs are obtained from their diet, while others are biotransformed, or de novo biosynthesized by the molluscs. Bacterial origin has been suggested for several types of compounds in heterobranchs [280]. However, very few studies rigorously demonstrate this.…”

Section: Discussionmentioning

confidence: 99%

Terpenoids in Marine Heterobranch Molluscs

Ávila

2020

Marine Drugs

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Heterobranch molluscs are rich in natural products. As other marine organisms, these gastropods are still quite unexplored, but they provide a stunning arsenal of compounds with interesting activities. Among their natural products, terpenoids are particularly abundant and diverse, including monoterpenoids, sesquiterpenoids, diterpenoids, sesterterpenoids, triterpenoids, tetraterpenoids, and steroids. This review evaluates the different kinds of terpenoids found in heterobranchs and reports on their bioactivity. It includes more than 330 metabolites isolated from ca. 70 species of heterobranchs. The monoterpenoids reported may be linear or monocyclic, while sesquiterpenoids may include linear, monocyclic, bicyclic, or tricyclic molecules. Diterpenoids in heterobranchs may include linear, monocyclic, bicyclic, tricyclic, or tetracyclic compounds. Sesterterpenoids, instead, are linear, bicyclic, or tetracyclic. Triterpenoids, tetraterpenoids, and steroids are not as abundant as the previously mentioned types. Within heterobranch molluscs, no terpenoids have been described in this period in tylodinoideans, cephalaspideans, or pteropods, and most terpenoids have been found in nudibranchs, anaspideans, and sacoglossans, with very few compounds in pleurobranchoideans and pulmonates. Monoterpenoids are present mostly in anaspidea, and less abundant in sacoglossa. Nudibranchs are especially rich in sesquiterpenes, which are also present in anaspidea, and in less numbers in sacoglossa and pulmonata. Diterpenoids are also very abundant in nudibranchs, present also in anaspidea, and scarce in pleurobranchoidea, sacoglossa, and pulmonata. Sesterterpenoids are only found in nudibranchia, while triterpenoids, carotenoids, and steroids are only reported for nudibranchia, pleurobranchoidea, and anaspidea. Many of these compounds are obtained from their diet, while others are biotransformed, or de novo biosynthesized by the molluscs. Overall, a huge variety of structures is found, indicating that chemodiversity correlates to the amazing biodiversity of this fascinating group of molluscs.

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Section: Discussionmentioning

confidence: 99%

Terpenoids in Marine Heterobranch Molluscs

Ávila

2020

Marine Drugs

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“…Nudibranchs, are one of many marine invertebrate groups that feed on marine sponges, a source of bioactive compounds. The bioactive compounds found in nudibranchs are greatly influenced by food and symbiotic bacteria (Fisch et al, 2017). Nudibranchs have a wide variety of bacteria that are affected by location and food.…”

Section: Discussionmentioning

confidence: 99%

Bioactivity of compounds secreted by symbiont bacteria of Nudibranchs from Indonesia

Kristiana

Bedoux

Pals

et al. 2020

PeerJ

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The aims of this work are to isolate bacterial symbionts from nudibranchs and subsequently to determine anti-Methicillin resistant Staphylococcus aureus (MRSA), cytotoxicity and anti-Herpes simplex virus type 1 (HSV-1) activities of bio compounds. A total of 15 species of nudibranchs were collected from Karimunjawa and five species from Bali, respectively. A total of 245 bacteria isolates were obtained. The anti-MRSA activity screening activity indicated two active bacteria. Ethyl acetate extracts from supernatants, indicating extracelullar compounds, showed an inhibition zone against MRSA at concentrations of 500-1,000 µg/ml. DNA sequence analysis showed that the strain KJB-07 from Phyllidia coelestis was closely related to Pseudoalteromonas rubra, whereas the strain NP31-01 isolated from Phyllidia varicosa was closely related to Virgibacillus salarius. The extract of Pseudoalteromonas rubra was cytotoxic to Vero cells at a concentration of 75 µg/ml. The extract of V. salarius presented no cytotoxicity at concentrations of 5-1,000 µg/ml. No anti HSV-1 was observed for both isolated bacteria. This is the first study describing research on anti-MRSA, cytotoxicity and anti HSV-1 activity of bacterial symbionts from the viscera of nudibranch. Compounds produced by Pseudoalteromonas rubra and V. salarius, had potential anti-MRSA activity. However, only extracts from Pseudoalteromonas rubra showed cytotoxic effects on Vero cells. Three compounds were identified by LC/MS after purification from culture supernatant. activity of marine bacteria associated with sponges from the waters off the coast of South East India. Microbiological Research 161 (3):252-262 DOI 10.1016/j.micres.2005.09.002. Avila C. 2006. Molluscan natural products as biological models: chemical ecology, histology, and laboratory culture. Chand S, Karuso P. 2017. Isolation and total synthesis of two novel metabolites from the fissurellid mollusc Scutus antipodes. Tetrahedron Letters 58(10):P. 1992. A one-step microbial DNA extraction method using "Chelex 100" suitable for gene amplification. Research in Microbiology 143(8):785-790

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“…Nudibranch dikenal sebagai biota beracun (Fisch et al, 2017), di mana tingkat racun biota ini dapat berubah-ubah disebabkan oleh perubahan pola makan, misalnya dari jenis makanan yang satu ke jenis makanan yang lain. Dalam penelitian ini dapat dilihat ada jenis menempati karang, tetapi juga ada yang menempati sponge ataupun alga.…”

Section: Metode Penelitianunclassified

Keragaman Substrat Bagi Nudibranch Di Selat Lembeh

Marpaung

Ompi

Manembu

et al. 2019

JPLT

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Research on the diversity of nudibranch substrates was carried out in Lembeh Strait at 3 locations, at Nudifall, Makawide, and Nudiritrit. The purpose of the researchs 1) to discover the nudibranch species at Nudifall, Makawide, Nudiritrit in the Lembeh Strait. 2) to knowing the substrate occupied by nudibranchs in the Lembeh Strait. 3) to knowing the overlapping substrate that was occupied by the nudibranch. Subtrates can to be used by nudibranches to get food sources, shelter from predators, and as a place to live. Nudibranch species found in the Lembeh Strait were 19 species in this study. Dead Coral with Algae (DCA), sponges, algae, hard coral, and tunicates were the types of substrate where nudibranches live in the Lembeh Strait The most dominant or overlapping substrate between types of nudibranchs was Dead Coral with Algae. Keywords : Nudibranch, Substrate, Lembeh Substrate diversity of nudibranch at Lembeh Strait Penelitian mengenai keragaman substrat nudibranch dilakukan di Selat Lembeh pada 3 lokasi yaitu Nudifall, Makawide, dan Nudiritrit. Tujuannya yaitu 1) mengetahui jen nudibranch di Nudifall, Makawide, Nudiritrit di Selat Lembeh. 2) mengetahui substrat yang ditempati nudibranch di Selat Lembeh. 3) mengetahui substrat yang tumpang tindih (overlap) yang ditempati oleh nudibranch. Subtrat dapat dimanfaatkan oleh nudibranch untuk mendapatkan sumber makanan, tempat berlindung dari predator, dan sebagai tempat tinggal. Jenis nudibranch yang ditemukan di Selat Lembeh ada 19 spesies dalam penelitian ini. Dead Coral with Algae (DCA), spons, alga, hard coral, dan tunikata merupakan substrat-substrat tempat hidup nudibranch di Selat Lembeh. Substrat yang paling dominan atau tumpang tindih antar jenis dari nudibranch adalah DCA. Kata kunci : Nudibranch, Substrat, Lembeh.

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The Potential of Indonesian Heterobranchs Found around Bunaken Island for the Production of Bioactive Compounds

Cited by 29 publications

References 195 publications

Terpenoids in Marine Heterobranch Molluscs

Terpenoids in Marine Heterobranch Molluscs

Bioactivity of compounds secreted by symbiont bacteria of Nudibranchs from Indonesia

Keragaman Substrat Bagi Nudibranch Di Selat Lembeh

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