The potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases

Abella, Vanessa; Scotece, Morena; Conde, Javier; Gómez, Rodolfo; Iglesias, Ana; Pino, Jesús; Gómez-Reino, Juan J.; Lago, Francisca; Mobasheri, Ali; Gualillo, Oreste

doi:10.3109/1354750x.2015.1123354

Cited by 229 publications

(201 citation statements)

References 73 publications

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“…This adipokine plays a role in innate immunity and acute phase response to infection, and has been reported to have roles in the induction of apoptosis in hematopoietic cells, modulation of oxidative stress and inflammation, and metabolic homeostasis. LCN2 has been investigated as a diagnostic and prognostic biomarker in numerous pathological conditions, such as cancer, tissue injury, inflammation and autoimmunity (34,35). Recently, LCN2 has also been proposed as a possible biomarker for disease activity and clinical response to antihistamine therapy in CU.…”

Section: Metabolic Syndromementioning

confidence: 99%

“…Hypoadiponectinemia is associated with a prothrombotic state, atherosclerosis, obesity, and MS (31-33). LCN2, also known as neutrophil gelatinase-associated lipocalin (NGAL), is a secreted glycoprotein that belongs to the lipocalin family of proteins that transport small hydrophobic ligands, such as steroid hormones, lipids and retinoids, and has recently been characterized as a member of the adipokines superfamily (34). This adipokine plays a role in innate immunity and acute phase response to infection, and has been reported to have roles in the induction of apoptosis in hematopoietic cells, modulation of oxidative stress and inflammation, and metabolic homeostasis.…”

Section: Metabolic Syndromementioning

confidence: 99%

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The link between chronic spontaneous urticaria and metabolic syndrome

Veña¹,

Cassano²

2017

Eur Ann Allergy Clin Immunol

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Summary Metabolic syndrome (MS) is a cluster of risk factors for cardiovascular disease and is considered a chronic low-level systemic inflammatory condition. Recent preliminary findings have shown an increased prevalence of MS among patients with chronic urticaria (CU) as compared to controls, with a particularly higher prevalence detected in patients with uncontrolled CU. Chronic spontaneous urticaria (CSU) appears to share some pathomechanisms with MS, including a pro-inflammatory state, increased oxidative stress, alterations in adipokine profile

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Section: Metabolic Syndromementioning

confidence: 99%

Section: Metabolic Syndromementioning

confidence: 99%

The link between chronic spontaneous urticaria and metabolic syndrome

Veña¹,

Cassano²

2017

Eur Ann Allergy Clin Immunol

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“…[10,11] It has a role in apoptosis, carcinogenesis, growth and differentiation of normal and neoplastic tissues, invasion and metastasis of cancer cells. Increased serum NGAL concentrations have been accepted as a prognosis-related independent variable in different types of cancer.…”

Section: Discussionmentioning

confidence: 99%

“…There are numerous studies on NGAL which indicate that it could be used as a tool for the diagnosis and monitoring of many diseases. [10][11][12] Higher expression levels and release of NGAL have been shown in acute and chronic inflammatory states as is the case with an acute phase reactant, and also in different cancer types (ovarian, colorectal, breast, esophageal, endometrial and prostate cancers). These studies have argued that NGAL and matrix metalloproteinases (MMP) are involved in extracellular matrix degradation by forming a complex, and NGAL can play an important role in the development, progress, and invasion of cancer.…”

Section: Introductionmentioning

confidence: 99%

“…[5][6][7][8][9] Recently a lipocalin family member glycoprotein neutrophil gelatinase-associated lipocalin (NGAL), also known as lipocalin-2, come into prominence as a cancer biomarker. [10][11][12] It is 25-kDa biomarker, and associated with cellular iron absorption, antibacterial activity and epithelial cell differentiation. NGAL was first discovered in neutrophils, and subsequently shown to be expressed in many tissues and cells.…”

Section: Introductionmentioning

confidence: 99%

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Neutrophil gelatinase- associated lipocalin as a screening test in prostate cancer

Muşlu

Ercan

Akbayir³

et al. 2017

Turkish Journal of Urology

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Objective: Prostate specific antigen (PSA) with digital rectal examination is used for diagnosis of prostate cancer (PCa), where definite diagnosis can only be made by prostate biopsy. Recently neutrophil gelatinaseassociated lipocalin (NGAL), a lipocalin family member glycoprotein, come into prominence as a cancer biomarker. This study is aimed to test serum NGAL as a diagnostic biomarker for PCa and discriminate PCa from benign prostatic hyperplasia (BPH). Material and methods:In this prospective study, 90 patients who underwent transrectal ultrasound-guided 12-core prostate biopsy between May 2015 and September 2015, were evaluated. Histopathologically diagnosed 45 PCa and 45 BPH patients were enrolled in this study. Serum NGAL and PSA levels of all participants were measured, then these data were evaluated by statistical programs. Results: When sensitivity fixed to 80% specificity of NGAL was better than PSA (49%, 31% respectively). Receiver operating characteristic (ROC) curve analysis showed that NGAL alone or its combined use with PSA have better area under curve (AUC) results than PSA alone (0.662, 0.693, and 0.623 respectively). Conclusion: In conclusion NGAL gave promising results such as increased sensitivity and a better AUC values in order to distinguish PCa from BPH. NGAL showed a potential to be a non-invasive biomarker which may decrease the number of unnecessary biopsies.

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Osteoblast‐derived extracellular vesicles exert osteoblastic and tumor‐suppressive functions via SERPINA3 and LCN2 in prostate cancer

Ito

Hayashi²,

Sato

et al. 2023

Molecular Oncology

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Clinically, the osteolytic phenotype is rare in prostate cancer (PCa), and the prognosis is generally worse than that of the osteoblastic phenotype. Osteoblastic prostate cancer (BPCa) is a major type of bone metastasis. Several factors responsible for osteogenesis have been identified, but the molecular mechanism of osteoblastic bone metastasis in PCa is not fully understood. Here, we show the osteogenic and tumor‐suppressive roles of SERPINA3 and LCN2 in BPCa. In a co‐culture of osteoblasts (OBs) and BPCa cells, SERPINA3 and LCN2 were remarkably upregulated in BPCa via OB‐derived extracellular vesicles, while they were not in the co‐culture of OBs and osteolytic prostate cancer (LPCa) cells. In both the co‐culture system and mouse xenograft experiments with intracaudal injection, enhanced expression of SERPINA3 and LCN2 in PCa led to osteogenesis. Additionally, the addition of SERPINA3 and LCN2 to BPCa cells significantly suppressed the proliferative potential. Retrospective analysis also confirmed that high expression levels of SERPINA3 and LCN2 were significantly correlated with a better prognosis. Our results may partially explain how osteoblastic bone metastasis develops and why the prognosis for BPCa is relatively better than that for LPCa.

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The potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases

Cited by 229 publications

References 73 publications

The link between chronic spontaneous urticaria and metabolic syndrome

The link between chronic spontaneous urticaria and metabolic syndrome

Neutrophil gelatinase- associated lipocalin as a screening test in prostate cancer

Osteoblast‐derived extracellular vesicles exert osteoblastic and tumor‐suppressive functions via SERPINA3 and LCN2 in prostate cancer

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