The potential of microelectrode arrays and microelectronics for biomedical research and diagnostics

Jones, Ian; Livi, Paolo; Lewandowska, Marta; Fiscella, Michele; Roscic, Branka; Hierlemann, Andreas

doi:10.1007/s00216-010-3968-1

Cited by 108 publications

(90 citation statements)

References 141 publications

(180 reference statements)

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“…Extracellular electrophysiological methods, on the other hand, yield weaker signals but allow long-term and multisite recordings of cellular networks due to reduced interference with cell viability. A well-established method for extracellular measurements relies on microelectrode arrays (MEAs) [3][4][5][6]. Fields of application for in vitro MEA systems include pharmacological highthroughput screening, cell-based biosensors, and research on information processing in neuronal networks [7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Frequency-dependent signal transfer at the interface between electrogenic cells and nanocavity electrodes

et al. 2012

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We present a model to describe the response of chip-based nanocavity sensors during extracellular recording of action potentials. These sensors feature microelectrodes which are embedded in liquid-filled cavities. They can be used for the highly localized detection of electrical signals on a chip. We calculate the sensor's impedance and simulate the propagation of action potentials. Subsequently we apply our findings to analyze cell-chip coupling properties. The results are compared to experimental data obtained from cardiomyocyte-like cells. We show that both the impedance and the modeled action potentials fit the experimental data well. Furthermore, we find evidence for a large seal resistance of cardiomyocytes on nanocavity sensors compared to conventional planar recording systems.

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Section: Introductionmentioning

confidence: 99%

Frequency-dependent signal transfer at the interface between electrogenic cells and nanocavity electrodes

et al. 2012

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“…Micro-electrode arrays (MEAs) can simultaneously record the action potentials of multiple cells or multiple neuronal synapses or organization propagation in a non-destructive manner, thus providing a powerful tool for these types of studies [45]. The Zhejiang University research group collects electrical signals by culturing olfactory nerve cells on the surface of MEAs and then analyzes their spiking rate, threshold and frequency.…”

Section: Investigating Cellular Mechanisms Of Pg Cells Based On Nervementioning

confidence: 99%

Progress in defining heterogeneity and modeling periglomerular cells in the olfactory bulb

Nan

Tian

et al. 2012

Sci. China Life Sci.

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In recent years the evolution of olfactory bulb periglomerular cells, as well as the function of periglomerular cells in olfactory encoding, has attracted increasing attention. Studies of neural information encoding based on the analysis of simulation and modeling have given rise to electrophysiological models of periglomerular cells, which have an important role in the understanding of the biology of these cells. In this review we provide a brief introduction to the anatomy of the olfactory system and the cell types in the olfactory bulb. We elaborate on the latest progress in the study of the heterogeneity of periglomerular cells based on different classification criteria, such as molecular markers, structure, ion channels and action potentials. Then, we discuss the several existing electrophysiological models of periglomerular cells, and we highlight the problems and defects of these models. Finally, considering our present work, we propose a future direction for electrophysiological investigations of periglomerular cells and for the modeling of periglomerular cells and olfactory information encoding.

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“…1 The advent of smart and ultrasmall (sub-mm) wireless sensing implants can bring an entirely new type of healthcare paradigm to bear as well as improve biomedical research and diagnostics. 2 This size scale will make the implantation and subsequent removal of such devices easier and cheaper.…”

Section: Introductionmentioning

confidence: 99%

Optical power transfer and communication methods for wireless implantable sensing platforms

et al. 2015

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Abstract. Ultrasmall scale implants have recently attracted focus as valuable tools for monitoring both acute and chronic diseases. Semiconductor optical technologies are the key to miniaturizing these devices to the longsought sub-mm scale, which will enable long-term use of these devices for medical applications. This can also enable the use of multiple implantable devices concurrently to form a true body area network of sensors. We demonstrate optical power transfer techniques and methods to effectively harness this power for implantable devices. Furthermore, we also present methods for optical data transfer from such implants. Simultaneous use of these technologies can result in miniaturized sensing platforms that can allow for large-scale use of such systems in real world applications.

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The potential of microelectrode arrays and microelectronics for biomedical research and diagnostics

Cited by 108 publications

References 141 publications

Frequency-dependent signal transfer at the interface between electrogenic cells and nanocavity electrodes

Frequency-dependent signal transfer at the interface between electrogenic cells and nanocavity electrodes

Progress in defining heterogeneity and modeling periglomerular cells in the olfactory bulb

Optical power transfer and communication methods for wireless implantable sensing platforms

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