The Potential of miR-370-3p and miR-495-3p Serving as Biomarkers for Sepsis-Associated Acute Kidney Injury

Ma, Wenlu; Miao, Xiaomei; Xia, Fangfang; Ruan, Chao; Tao, Dan; Li, Bing

doi:10.1155/2022/2439509

Cited by 4 publications

(3 citation statements)

References 20 publications

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“…Some studies have indicated that miR-370-3p could be a biomarker for early diagnosis of sepsis-associated acute kidney injury (SA-AKI). Compared with non-AKI invalids, miR-370-3p were obviously lower in the urine of AKI invalids [46]. Since miR-370-3p is stable enough in blood and has a correlation with GCs and SOFA score, it may be a sensitive biomarker for sepsis induced neuronal damage or BBB impairment [45].…”

Section: Mir-370-3pmentioning

confidence: 97%

Research Progress of Biomarkers of Sepsis-Associated Encephalopathy

et al. 2023

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Sepsis-associated encephalopathy (SAE) is a common complication of sepsis, raise the mortality rate with an incidence of up to 71%. Pathological neuroinflammation after sepsis leads to acute brain dysfunction, survivors may remain long-term cognitive impairment. At present, the evaluation of SAE severity and prognosis mainly depends on clinical manifestations and imaging features, but lack of effectiveness and timeliness. Biomarkers of nerve injuries nowadays, have shown good application value and perspectives in the diagnosis and evaluation of SAE. This article will review the current biomarkers for accurate diagnosis and evaluation, basing on the possible pathophysiological mechanism of different stages of SAE.

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Section: Mir-370-3pmentioning

confidence: 97%

Research Progress of Biomarkers of Sepsis-Associated Encephalopathy

et al. 2023

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“…Apart from serum and urinary biomarkers, there is ongoing research regarding molecular biomarkers of SA-AKI. In particular, gene expression profiles in SA-AKI together with biomarkers stemming from proteomics and metabolomics have revolutionized the field of SA-AKI in terms of diagnosis and prognosis [ 56 , 57 , 58 , 59 , 60 , 61 , 62 ]. Regarding gene expression profiles, Guo et al have very recently demonstrated that the AFM gene, also called “afamin”, which is a member of the albumin family of genes, may be a surrogate biomarker for SA-AKI.…”

Section: Biomarkers In Sa-akimentioning

confidence: 99%

“…Furthermore, N-6 adenosine methylation, m6A and RNA methylation modifications were shown to be involved in SA-AKI [ 58 ]. Moreover, Ma et al proposed that the reduction in the expressions of miR-370-3p and miR-495-3p in the urine of patients with SA-AKI are biomarkers in SA-AKI [ 59 ]. Very recently, apart from non-coding RNAs, Ma et al have studied the role of circular RNAs in the development of SA-AKI.…”

Section: Biomarkers In Sa-akimentioning

confidence: 99%

Sepsis-Associated Acute Kidney Injury: Where Are We Now?

Kounatidis,

Vallianou,

Psallida

et al. 2024

Medicina

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Worldwide, sepsis is a well-recognized cause of death. Acute kidney injury (AKI) may be related to sepsis in up to 70% of AKI cases. Sepsis-associated AKI (SA-AKI) is defined as the presence of AKI according to the Kidney Disease: Improving Global Outcomes criteria in the context of sepsis. SA-AKI is categorized into early, which presents during the first 48 h of sepsis, and late, presenting between 48 h and 7 days of sepsis. SA-AKI is associated with a worse prognosis among patients with sepsis. However, there are different SA-AKI phenotypes as well as different pathophysiological pathways of SA-AKI. The aim of this review is to provide an updated synopsis of the pathogenetic mechanisms underlying the development of SA-AKI as well as to analyze its different phenotypes and prognosis. In addition, potential novel diagnostic and prognostic biomarkers as well as therapeutic approaches are discussed. A plethora of mechanisms are implicated in the pathogenesis of SA-AKI, including inflammation and metabolic reprogramming during sepsis; various types of cell death such as apoptosis, necroptosis, pyroptosis and ferroptosis; autophagy and efferocytosis; and hemodynamic changes (macrovascular and microvascular dysfunction). Apart from urine output and serum creatinine levels, which have been incorporated in the definition of AKI, several serum and urinary diagnostic and prognostic biomarkers have also been developed, comprising, among others, interleukins 6, 8 and 18, osteoprotegerin, galectin-3, presepsin, cystatin C, NGAL, proenkephalin A, CCL-14, TIMP-2 and L-FABP as well as biomarkers stemming from multi-omics technologies and machine learning algorithms. Interestingly, the presence of long non-coding RNAs (lncRNAs) as well as microRNAs (miRNAs), such as PlncRNA-1, miR-22-3p, miR-526b, LncRNA NKILA, miR-140-5p and miR-214, which are implicated in the pathogenesis of SA-AKI, may also serve as potential therapeutic targets. The combination of omics technologies represents an innovative holistic approach toward providing a more integrated view of the molecular and physiological events underlying SA-AKI as well as for deciphering unique and specific phenotypes. Although more evidence is still necessary, it is expected that the incorporation of integrative omics may be useful not only for the early diagnosis and risk prognosis of SA-AKI, but also for the development of potential therapeutic targets that could revolutionize the management of SA-AKI in a personalized manner.

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Kidney Injury: Focus on Molecular Signaling Pathways

Liu,

Hu,

Wang

et al. 2024

CMC

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Acute kidney injury (AKI) is a syndrome in which kidney function reduces suddenly. This syndrome which includes both structural changes and loss of function may lead to chronic kidney disease (CKD). Kidney regeneration capacity depends on the cell type and severity of the injury. However, novel studies indicated that regeneration mostly relies on endogenous tubular cells that survive after AKI. Regenerative pharmacology requires a great knowledge of fundamental processes involved in the development and endogenous regeneration, leading to a necessity for investigating related signaling molecules in this process. Regulatory non-coding RNAs (ncRNAs) including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) are currently known as critical regulators of gene expression in various cellular processes, and this regulatory function is also observed in nephrotic tissue, following damaging insults, which may promote or inhibit the progression of damage. Thus, studying signaling molecules and pathways involved in renal injury and repair results in a comprehensive prospect of these processes. Moreover, these studies can lead to new opportunities for discovering and enhancing therapeutic approaches to renal diseases. Herein, we review studies dealing with the role of different signaling pathways involved in renal injury. Besides, we discuss how some signaling pathways are useful for the repair process following AKI.

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The Potential of miR-370-3p and miR-495-3p Serving as Biomarkers for Sepsis-Associated Acute Kidney Injury

Cited by 4 publications

References 20 publications

Research Progress of Biomarkers of Sepsis-Associated Encephalopathy

Research Progress of Biomarkers of Sepsis-Associated Encephalopathy

Sepsis-Associated Acute Kidney Injury: Where Are We Now?

Kidney Injury: Focus on Molecular Signaling Pathways

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