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Amino-functionalized graphene oxide (GO-NH2) was prepared for enhanced antibacterial properties through excellent photothermal efficiency. This nanosheet could easily target the bacterial surface through electrostatic attraction. Upon white light irradiation, GO-NH2 with superior antibacterial efficacy could inhibit the growth of Gram-negative and Gram-positive bacteria, resulting in an increase to 32-times more than the antibacterial activity of GO alone. Through studies of the antibacterial mechanism, it was found that the nanosheets could destroy the cytomembrane of bacteria, resulting in cytoplasmic leakage. Moreover, the analysis of cell proliferation indicated that the nanosheets had good biocompatibility. This work indicates that graphene oxide could be used as a new nanostructured carbon material to construct an antimicrobial agent for photothermal therapy in the biomedical field.

In this work, the superhydrophobic fabric was fabricated by surface modification with mercaptopropyltriethoxysilane to incorporate thiol groups and subsequent thiol-ene click chemistry with methacryloxypropyltrimethoxysilane (MPS)-modified SiO2@Fe3O4 nanoparticles (MPS-SiO2@Fe3O4) in the assistance of ultraviolet light. The Fourier-transform infrared, X-ray photoelectron spectroscopy, and scanning electron microscopy measurement results demonstrated that the MPS-SiO2@Fe3O4 nanoparticles were strongly grafted onto the fabric surface via a chemically covalent bond and constructed a hierarchical micro/nanoscale structure combined with the inherent microstructure of pristine fabric. Under combination of such hierarchical structures and the inherent low surface energies of hydrophobic Si skeleton and alkyl groups, the resulting fabric exhibited superhydrophobicity and could be used to separate oil from the oil/water mixture accompanying with high separation efficiency, permeate flux, and excellent recyclability. Furthermore, the as-prepared fabric displayed excellent superhydrophobic durability against tape-peeling, abrasion, and chemicals like strong acidic and alkaline solutions, which should be ascribed to the strong interactions between the MPS-SiO2@Fe3O4 and fabric surface by strong chemical bonds. Therefore, this work not only provided a facile, environmentally friendly, and versatile strategy for fabricating the superhydrophobic composites but also opened a door to preserve the durable superhydrophobicity, exhibiting promising prospect in the application of oil/water separation.

Objective. This study is aimed at evaluating the miR-370-3p and miR-495-3p expression in the urine of patients with sepsis-associated acute kidney injury (SA-AKI) and exploring its diagnosis value in for SA-AKI. Methods. 184 sepsis invalids were collected and divided two groups (non-AKI group or AKI group) according to whether they had acute kidney injury. RT-qPCR was utilized to measure miR-370-3p and miR-495-3p expressions. ROC curve was performed to evaluate the diagnostic value of miR-370-3p and miR-495-3p for SA-AKI. Patients diagnosed with SA-AKI were followed up for 28 days to record survival time. The prognostic performance of miR-370-3p and miR-495-3p for SA-AKI was evaluated by survival curves. Results. Compared with non-AKI invalids, miR-370-3p and miR-495-3p expressions were obviously lower in the urine of AKI invalids. miR-370-3p and miR-495-3p expressions were markedly negatively correlated with biomarkers of renal injury. Furthermore, the area under the curve (AUC) of miR-370-3p and miR-495-3p for diagnosing sepsis SA-AKI was 0.896 and 0.814, respectively. The higher 28 days-survival rate was observed in patients with high miR-370-3p and miR-495-3p expressions. Conclusions. A novel biomarker for the early diagnosis of SA-AKI may be miR-370-3p and miR-495-3p, which was clearly reduced in the urine of SA-AKI patients.