The potential of nanoparticles in stem cell differentiation and further therapeutic applications

Dayem, Ahmed Abdal; Choi, Hye Yeon; Yang, Gwang-Mo; Kim, Kyeongseok; Saha, Subbroto Kumar; Kim, Jin‐Hoi; Cho, Ssang-Goo

doi:10.1002/biot.201600453

Cited by 47 publications

(31 citation statements)

References 95 publications

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“…The rapid development of nanotechnology provides a variety of nanomaterials, especially metal nanoparticles, carbon nanomaterials, semiconductor nanomaterials, polymeric nanoparticles and DNA nanostructures, which are promising in regulating stem cell behavior and tissue regeneration [ 135 , 136 ]. Nanomaterials can potently modulate the drug-loaded release or microenvironments involved in stem cell differentiation, and enhance their efficiency and safety [ 123 ].…”

Section: Discussionmentioning

confidence: 99%

Nanomaterials modulate stem cell differentiation: biological interaction and underlying mechanisms

Wei

2017

J Nanobiotechnol

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Stem cells are unspecialized cells that have the potential for self-renewal and differentiation into more specialized cell types. The chemical and physical properties of surrounding microenvironment contribute to the growth and differentiation of stem cells and consequently play crucial roles in the regulation of stem cells’ fate. Nanomaterials hold great promise in biological and biomedical fields owing to their unique properties, such as controllable particle size, facile synthesis, large surface-to-volume ratio, tunable surface chemistry, and biocompatibility. Over the recent years, accumulating evidence has shown that nanomaterials can facilitate stem cell proliferation and differentiation, and great effort is undertaken to explore their possible modulating manners and mechanisms on stem cell differentiation. In present review, we summarize recent progress in the regulating potential of various nanomaterials on stem cell differentiation and discuss the possible cell uptake, biological interaction and underlying mechanisms.

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Section: Discussionmentioning

confidence: 99%

Nanomaterials modulate stem cell differentiation: biological interaction and underlying mechanisms

Wei

2017

J Nanobiotechnol

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“…Thus, delivery of these synthetic material in vivo may recapitulate similar effects to promote proper tissue restoration and phenotype recovery. [119][120][121] ECM modifications can also be performed by directly injecting…”

Section: Secretome-based Rejuvenationmentioning

confidence: 99%

Restoring aged stem cell functionality: Current progress and future directions

2020

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Stem cell dysfunction is a hallmark of aging, associated with the decline of physical and cognitive abilities of humans and other mammals [Cell 2013;153:1194]. Therefore, it has become an active area of research within the aging and stem cell fields, and various techniques have been employed to mitigate the decline of stem cell function both in vitro and in vivo. While some techniques developed in model organisms are not directly translatable to humans, others show promise in becoming clinically relevant to delay or even mitigate negative phenotypes associated with aging. This review focuses on diet, treatment, and small molecule interventions that provide evidence of functional improvement in at least one type of aged adult stem cell.

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“…One research team examined the effect of a small size of AuNPs (4 nm) on the differentiation of hBM-MSCs compared with large size AuNPs (40 nm). The small AuNPs markedly suppressed osteogenic differentiation, while promoting the adipogenic differentiation of hBM-MSCs [ 122 ]. This effect is ascribed to ROS production by the small size AuNPs that resulted in a differential differentiation effect.…”

Section: Metallic Nps and Stem Cell Differentiation And Proliferatmentioning

confidence: 99%

The Impact of Metallic Nanoparticles on Stem Cell Proliferation and Differentiation

2018

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Nanotechnology has a wide range of medical and industrial applications. The impact of metallic nanoparticles (NPs) on the proliferation and differentiation of normal, cancer, and stem cells is well-studied. The preparation of NPs, along with their physicochemical properties, is related to their biological function. Interestingly, various mechanisms are implicated in metallic NP-induced cellular proliferation and differentiation, such as modulation of signaling pathways, generation of reactive oxygen species, and regulation of various transcription factors. In this review, we will shed light on the biomedical application of metallic NPs and the interaction between NPs and the cellular components. The in vitro and in vivo influence of metallic NPs on stem cell differentiation and proliferation, as well as the mechanisms behind potential toxicity, will be explored. A better understanding of the limitations related to the application of metallic NPs on stem cell proliferation and differentiation will afford clues for optimal design and preparation of metallic NPs for the modulation of stem cell functions and for clinical application in regenerative medicine.

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The potential of nanoparticles in stem cell differentiation and further therapeutic applications

Cited by 47 publications

References 95 publications

Nanomaterials modulate stem cell differentiation: biological interaction and underlying mechanisms

Nanomaterials modulate stem cell differentiation: biological interaction and underlying mechanisms

Restoring aged stem cell functionality: Current progress and future directions

The Impact of Metallic Nanoparticles on Stem Cell Proliferation and Differentiation

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