The Potential of Sulfated Polysaccharides Isolated from the Brown Seaweed Ecklonia maxima in Cosmetics: Antioxidant, Anti-melanogenesis, and Photoprotective Activities

Abstract

Sulfated polysaccharides prepared from marine algae are potential ingredients in nutraceutical, pharmaceutical, and cosmeceutical industries. In the present study, the antioxidant, anti-melanogenesis, and photoprotective effects of sulfated polysaccharides obtained from Ecklonia maxima (EMC) were investigated to evaluate their potential in cosmetic. EMC was successfully prepared through Celluclast-assisted extraction and ethanol precipitation, and it contained 79.88% of sulfated polysaccharides that with 69.37% carbohydrates and 10.51% sulfate. EMC effectively suppressed 2,2-azobis(2-amidinopropane) hydrochloride (AAPH)-induced oxidative stress in vitro in Vero cells and in vivo in zebrafish. Furthermore, EMC significantly inhibited mushroom tyrosinase and reduced melanin synthesis in alpha-melanocyte-stimulating hormone-stimulated B16F10 cells. In addition, EMC remarkably attenuated photodamage induced by UVB irradiation in vitro in human keratinocytes (HaCaT cells) and in vivo in zebrafish. Furthermore, EMC effectively inhibited wrinkle-related enzymes and improved collagen synthesis in UVB-irradiated human dermal fibroblasts (HDF cells). These results indicate that EMC possesses strong antioxidant, anti-melanogenesis, and photoprotective activities, and suggest that EMC may be an ideal ingredient in the pharmaceutical and cosmeceutical industries.

Anti-Fine Dust Effect of Fucoidan Extracted from Ecklonia maxima Leaves in Macrophages via Inhibiting Inflammatory Signaling Pathways

“…The chemical compositions of the crude extract, Celluclast-assisted extract, and the ethanol-precipitated component of E. maxima were determined. The proximate composition results were reported in our previous study [32]. The polysaccharide and sulfate contents of the Celluclast-assisted extract were 42.37 ± 0.48% and 6.29 ± 0.56%, respectively, while those of the ethanol-precipitated component were 69.37 ± 0.16% and 10.51 ± 0.23%, respectively.…”

Unravelling the Dermatological Potential of the Brown Seaweed Carpomitra costata

“…In a study performed by Rui and co-workers [54], mycosporine-like amino acids (MAAs) extracted from the macroalgae Porphyra tenera, inhibited the expression of collagenase and another extracellular matrix related MMPs. Moreover, sulphated polysaccharides have been previously described as being able to suppress tyrosinase activity [55].…”

Extraction Procedure, Characteristics, and Feasibility of Caulerpa microphysa (Chlorophyta) Polysaccharide Extract as a Cosmetic Ingredient

“…Moisturizing is the most important function of skincare products. Effective moisturizing facilitates active moisture absorption and retention by the skin [ 48 ]. The moisture absorption and moisture retention properties of CME were therefore assessed and compared with those of several cosmetics on the market in this study.…”