The Potential Protective Effect ofPhysalis peruvianaL. against Carbon Tetrachloride-Induced Hepatotoxicity in Rats Is Mediated by Suppression of Oxidative Stress and Downregulation of MMP-9 Expression

Abstract

The active constituent profile in Cape gooseberry (Physalis peruviana L.) juice was determined by GC-MS. Quercetin and kaempferol were active components in the juice. In this study we have evaluated its potential protective effect on hepatic injury and fibrosis induced by carbon tetrachloride (CCl4). Twenty-eight rats divided into 4 groups: Group I served as control group, and Group II received weekly i.p. injection of 2 mL CCl4/kg bwt for 12 weeks. Group III were supplemented with Physalis juice via the drinking water. The animals of Group IV received Physalis juice as Group III and also were intraperitoneally injected weekly with 2 mL CCl4/kg bwt for 12 weeks. Hepatoprotective effect was evaluated by improvement in liver enzymes serum levels, reduction in collagen areas, downregulation in expression of the fibrotic marker MMP-9, reduction in the peroxidative marker malonaldehyde and the inflammatory marker nitric oxide, and restoration of the activity of antioxidant enzymatic and nonenzymatic systems, namely, glutathione content, superoxide dismutase, catalase, glutathione-S-transferase, glutathione peroxidase, and glutathione reductase activities. The results show that the potential hepatoprotective effects of Physalis peruviana may be due to physalis acts by promotion of processes that restore hepatolobular architecture and through the inhibition of oxidative stress pathway.

Antioxidant activity and free radical-scavenging of cape gooseberry (Physalis peruviana L.) in hepatocellular carcinoma rats model

“…Additionally, the observed increase in alterations to liver enzymes, including ALT, AST and ALP, in HCCreceived CHJ rats may be due to the improvement of the functional status of hepatocytes with preservation of cellular architecture leakage of intracellular enzymes through membrane-stabilizing activity. [18,53] Previous studies have suggested that CGJ is a significant source of natural antioxidative compounds.…”

Amelioration of Hepato-Renal Toxicity by a Flavonoid-Rich Fraction of Hibiscus rosa-sinenses (Leaves and Flowers) in Male Rabbits Intoxicated by Cadmium

“…Concentrations of Cd in an adjacent environment is cumulative owing to its miscellaneous sources and very long biological half-life ranging from 10 to 30 years. Cd in biological systems is dispensable and it is known to be toxic even at low concentrations [2][3]. Cadmium exposure (acute and chronic) in plants, animals, and humans may cause harm to various organs, including the brain, gastro-intestinal tract, liver, lungs, and testes.…”

“…Cadmium exposure (acute and chronic) in plants, animals, and humans may cause harm to various organs, including the brain, gastro-intestinal tract, liver, lungs, and testes. Many related disorders include renal dysfunction, hepatotoxicity, anemia, osteoporosis, DNA damage, neurodegenerative diseases, and immunosuppressive and proinflammatory effects [3][4][5][6]. A number of mechanisms have been proposed to explain the damage induced by Cd, but it is not yet well understood, although some experimental evidence can determine that deleterious effects of cadmium are due to oxidative stress by depletion of the endogenous antioxidants that serve as a premier source of protection against free radicals and other oxidative stressors.…”

“…A number of mechanisms have been proposed to explain the damage induced by Cd, but it is not yet well understood, although some experimental evidence can determine that deleterious effects of cadmium are due to oxidative stress by depletion of the endogenous antioxidants that serve as a premier source of protection against free radicals and other oxidative stressors. Conventionally, ethno medicines are being used widely in the sub-continent and elsewhere generally owing to their low cost, easy accessibility, and apparentlt reduced side effects [3]. The mechanism of action of these herbal remedies is diverse in many respects from that of the synthetic drugs/pure compounds.…”

Exploring the potential of an Andean fruit : an interdisciplinary study on the cape gooseberry (Physalis peruviana L.) value chain

“…A number of studies has been conducted to test health properties of Physalis peruviana L plant, cape gooseberry and calyx, concluding to a potential association of intakes with in vitro and in vivo anti-inflammatory activity [25,26], inhibition of TPA-induced (12-O-tetradecanoylphorbol-13-acetate) oedema in mice [27], effectiveness in decreasing cadmium toxicity in rats [28,8,29], hepatoprotective, renoprotective and cholesterol suppression effects [8,[30][31][32][33][34], antidiabetic and antihypertension activity [35][36][37][38][39] and cytotoxic activity against in vitro non-specific cancer cells [40] and lung cancer cells [41]. These potential health benefits are associated with the presence of phytochemicals in the extracts such as withanolides, physalins, vitamin C, flavonoids and phenolics, among others.…”