The Potential Protective Effect of Low Potassium Dextran against Lipid Peroxidation in a Rat Lung Transplantation Model

Abstract

The overproduction of reactive oxygen species plays an important role in the cascade of events during lung ischemia-reperfusion leading to graft failure. An evaluation of the peripheral markers of oxidative stress and antioxidant enzyme activities was carried out after reperfusion in a rat lung transplant model. The decrease in lipid peroxidation immediately after transplantation ( P < 0.05) may suggest an adaptative response and/or a protective effect of low potassium dextran against lipid peroxidation through natural scavenging mechanisms.

Maresin 1 Ameliorates Lung Ischemia/Reperfusion Injury by Suppressing Oxidative Stress via Activation of the Nrf‐2‐Mediated HO‐1 Signaling Pathway

“…The level of tissue MDA and 15-F2t-isoprostane, which is the product of lipid peroxidation, was significantly increased in the lung after ischemic reperfusion. These reactions exacerbate the inflammatory response and lung dysfunction, leading to pulmonary edema and gas exchange impedance [20, 30]. …”

Endobronchial Perfluorocarbon Reduces Inflammatory Activity before and after Lung Transplantation in an Animal Experimental Model

“…Similar results have been found in a previous study by Pilla et al [10] in an animal model of ischemic preconditioning. However, studies that used different techniques have found significant differences in oxidative stress in a similar animal model of lung transplantation [9, 37]. Lastly, endobronchial PFC has been shown to protect lungs against reactive oxygen species after lung transplantation, as demonstrated by an increase in superoxide dismutase [38].…”

“…The recipient animals were anesthetized, intubated (14-gauge catheter), and ventilated. They then underwent a left thoracotomy, and the pulmonary vessels and left bronchus were anastomosed using a standard cuff technique [9]. Transplants were performed to 6 animals per group, totaling 24 animals.…”

Cold-induced injury to lung epithelial cells can be inhibited by iron chelators — implications for lung preservation☆

“…Only LPD solution showed marginal superiority, possibly due to its component dextran, for which additional properties have been described aside its oncotic effect; it is even discussed whether dextran plays a role in reducing the production of reactive oxygen species [14]. However, even LPD solution could not offer the protection observed by the addition of iron chelators.…”