The potential role of fatty liver in paediatric metabolic syndrome: a distinct phenotype with high metabolic risk?

Abstract

We propose that NAFLD should be routinely checked in obese subjects because early lifestyle changes may be effective in reducing the overall risk of MS.

Alanine aminotransferase and metabolic syndrome in adolescents: the Korean National Health and Nutrition Examination Survey Study

“…Insulin resistance increases absorption of free fatty acid into liver, and the hepatic fatty acid is re‐synthesized into triglyceride, resulting in NAFLD with ALT elevation . Therefore, ALT elevation/NAFLD is widely recognized as a hepatic component of MetS .…”

Fatty liver disease, glucose tolerance and insulin resistance in obese adolescents

“…An independent association between hepatic fat and insulin resistance has been suggested by a number of studies and discussed in reviews . Seppala‐Lindroos et al .…”

“…An independent association between hepatic fat and insulin resistance has been suggested by a number of studies and discussed in reviews (17,18). Seppala-Lindroos et al found in normal men that hepatic fat was associated with defects in insulin suppression of both glucose production and serum-free fatty acids that were independent of obesity (2).…”

Dyslipidemia: Relationship to Insulin Resistance, Fatty Liver, and Sub-Clinical Atherosclerosis

“…As a result, excess FFAs are converted to TAG in the liver and stored in hepatocytes or carried into the bloodstream by VLDL. As liver fat increases, VLDL secretions result in high TAG and low HDL levels in the plasma, further increasing systemic insulin resistance [16]. Since insulin resistance, MetS, and fatty liver are interrelated, it is difficult to determine whether systemic insulin resistance causes fatty liver, or if liver fat contributes to the development of insulin resistance, or both.…”