The potential role of nutrition on lens pathology: a systematic review and meta-analysis

Sideri, Olympia; Tsaousis, Konstantinos T.; Li, He J.; Viskadouraki, Maria; Tsinopoulos, Ioannis

doi:10.1016/j.survophthal.2019.03.003

Cited by 21 publications

(12 citation statements)

References 56 publications

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“…23 In a study in south India, the frequency of Posterior sub capsular (PSC) opacities was greater than in western population and also had found no significant difference for vitamin A. in different types of cataract. 24 Blood levels of antioxidants might be influenced by lifestyle, environmental factors and individual variance in the absorption.…”

Section: Discussionmentioning

confidence: 99%

Serum vitamin A, E & C in cortical & nuclear cataract patients.

Ghazala¹,

Siddiqui²,

Ali³

et al. 2021

TPMJ

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Objective: To assess the status of antioxidant vitamins (A, E & C) in cortical and nuclear cataracts patients. Study Design: Prospective Comparative study. Setting: Al-Ibrahim Eye Hospital and Biochemistry Department of Al-Tibri Medical College, Karachi. Period: Sept 2016 to Aug 2017. Material & Methods: A non-probability random sampling technique was used on 80 pre-diagnosed cataracts (cortical and nuclear) patients, and 40 control subjects were selected for the study. The demographic data were collected, and the blood sample of control and cataract patients were analyzed for random blood sugar and antioxidant vitamins (A, E, and C) by Elisa Method. Results: The Blood level of vitamins E was low in cataract patients as compared to control subjects. Conclusions: The blood level of vitamin E is less in cortical and nuclear cataract patients as compared to control but had shown no significant difference between cortical and nuclear cataract patients.

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Section: Discussionmentioning

confidence: 99%

Serum vitamin A, E & C in cortical & nuclear cataract patients.

Ghazala¹,

Siddiqui²,

Ali³

et al. 2021

TPMJ

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“…Thus, antioxidant nutrients have been investigated for their roles in mitigating the risk of development of cataracts. One review that included observational studies found that vitamin C, beta carotene, lutein and zeaxanthin exerted the protective effect of antioxidation on cataracts [ 98 ]. A meta-analysis based on cohort studies and RCT concluded that supplementation of vitamin A, vitamin E, vitamin C, beta carotene, lutein and zeaxanthin was associated with the reduced risk of age-related cataracts [ 99 ].…”

Section: Role Of Nutrition In Healthy Ageing In Asiamentioning

confidence: 99%

The Role of Micronutrients in Ageing Asia: What Can Be Implemented with the Existing Insights

Inui¹,

Hanley

Tee

et al. 2021

Nutrients

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Life expectancy as a measure of population health does not reflect years of healthy life. The average life expectancy in the Asia-Pacific region has more than doubled since 1900 and is now above 70 years. In the Asia-Pacific region, the proportion of aged people in the population is expected to double between 2017 and 2050. Increased life expectancy leads to an increase in non-communicable diseases, which consequently affects quality of life. Suboptimal nutritional status is a contributing factor to the prevalence and severity of non-communicable diseases, including cardiovascular, cognitive, musculoskeletal, immune, metabolic and ophthalmological functions. We have reviewed the published literature on nutrition and healthy ageing as it applies to the Asia-Pacific region, focusing on vitamins, minerals/trace elements and omega-3 fatty acids. Optimal nutritional status needs to start before a senior age is reached and before the consequences of the disease process are irreversible. Based on the nutritional status and health issues in the senior age in the region, micronutrients of particular importance are vitamins A, D, E, C, B-12, zinc and omega-3 fatty acids. The present paper substantiates the creation of micronutrient guidelines and proposes actions to support the achievement of optimal nutritional status as contribution to healthy ageing for Asia-Pacific populations.

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“…Various antioxidant enzymes and proteins, such as catalase, peroxiredoxin 6, superoxide dismutase, glutathione peroxidase, and glutathione, have been reported to be present in the lens and to be involved in maintaining lenticular homeostasis [7][8][9][10]. It has been reported that the administration of antioxidants reduces the risk of cataract progression [6,9,[11][12][13][14]. For example, lutein (LU) and zeaxanthin, which are naturally occurring carotenoids in the eye, have the potential to reduce cataract progression by absorbing short-wavelength visible light and quenching ROS [15,16].…”

Section: Introductionmentioning

confidence: 99%

Lutein plus Water Chestnut (Trapa bispinosa Roxb.) Extract Inhibits the Development of Cataracts and Induces Antioxidant Gene Expression in Lens Epithelial Cells

Ishida

Shibata

et al. 2020

BioMed Research International

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Age-related cataract (ARC) is the major cause of blindness worldwide. The most significant factors are the maximal exposure of the eye lens to environmental stressors, including oxidative and glycative load. The administration of antioxidant and antiglycative supplements may reduce the risk of cataract progression. In this study, the effects of lutein (LU) and water chestnut (Trapa bispinosa Roxb.) extract (TBE) on cataracts and the expression of antioxidant-related genes were assessed in Shumiya cataract rats (SCRs). LU+TBE or castor oil (COil) as a control was administered to 6- or 9-week-old cataractous SCRs and noncataractous SCRs via a feeding needle for 3 or 4 weeks. Five-week-old SCRs were provided ad libitum access to solid regular chow containing LU, TBE, LU+TBE, or the same chow without LU and/or TBE for 3 weeks. Lenses from all rats were then extracted and photographed. The right eyes of the rats were processed for histological observation, and the left eyes were used for total RNA extraction from lens epithelial cells (LEC). The mRNA levels of antioxidant proteins, peroxiredoxin 6, and catalase were examined using real-time quantitative polymerase chain reaction. Lens opacity appeared in all cataractous SCRs that began receiving LU+TBE at 9 weeks of age. However, compared to the COil group, lens opacity was decreased in the cataractous LU+TBE SCRs in all experiments. The mRNA expression levels of peroxiredoxin 6 and catalase in LECs of cataractous SCRs and cultured human LECs increased after the administration of LU+TBE. Collectively, our results highlight the anticataract and antioxidative effects of LT+TBE in SCRs. LT+TBE supplementation may, thus, be useful in delaying cataract progression.

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The potential role of nutrition on lens pathology: a systematic review and meta-analysis

Cited by 21 publications

References 56 publications

Serum vitamin A, E & C in cortical & nuclear cataract patients.

Serum vitamin A, E & C in cortical & nuclear cataract patients.

The Role of Micronutrients in Ageing Asia: What Can Be Implemented with the Existing Insights

Lutein plus Water Chestnut (Trapa bispinosa Roxb.) Extract Inhibits the Development of Cataracts and Induces Antioxidant Gene Expression in Lens Epithelial Cells

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