The potential role of oxytocin and perinatal factors in the pathogenesis of autism spectrum disorders – review of the literature

Vanya, Melinda; Szűcs, Szabina; Vetró, Ágnes; Bártfai, György

doi:10.1016/j.psychres.2016.12.007

Cited by 21 publications

(15 citation statements)

References 37 publications

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“…Breast milk contains various substances (e.g., essential fatty acids, insulin‐like grow factor, oxytocin, melatonin) involved in brain development and maturation [Deoni et al, ; Hall, ; Herba et al, ; Koletzo et al, ; Steinman & Mankuta, ]. Breastfeeding promotes mother–child bonding through release of maternal hormones (e.g., prolactin, oxytocin), which can affect social behaviors in the mother and the child [Feldman et al, ; Kim et al, ; Vanya, Szucs, Vetro, & Bartfai, ; Zhang, Zhang, Han, & Han, ]. Breast milk contains immune factors that protect a child against various infections.…”

Section: Introductionmentioning

confidence: 99%

Association Between Breastfeeding Initiation and Duration and Autism Spectrum Disorder in Preschool Children Enrolled in the Study to Explore Early Development

et al. 2019

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Studies report inconsistent findings on the relationship between ASD and breastfeeding. We explored associations between ASD and breastfeeding initiation (yes/no) and duration (months categorized in tertiles) in the Study to Explore Early Development, a community-based case-control study in six sites in the Unites States. We adjusted for various child and mother demographic and pregnancy factors. Breastfeeding initiation was reported in 85.7% of mothers of children with ASD and 90.6% of mothers of controls. After adjustment, we found no significant difference in breastfeeding initiation (adjusted odds-ratio [aOR]: 0.88 and 95% confidence interval (CI) 0.60-1.28). However, mothers of children with ASD were less likely to report duration of breastfeeding in the high (≥12 months) versus low tertile (<6 months) (aOR and 95% CI: 0.61 [0.45-0.84]) or the middle (6-<12 months) versus low tertile (0.72: 0.54-0.98). The association of ASD and breastfeeding duration was slightly attenuated when the presence of the broader autism phenotype (BAP) in the mother was accounted for, but still remained for the highest tertile. This association does not appear to be totally explained by maternal BAP. We were unable to distinguish whether the difference in duration was due to difficulties breastfeeding children who later develop ASD, other factors not adjusted in our study, or greater ASD risk resulting from shorter breastfeeding duration. Longitudinal studies that compare reasons why mothers stop breastfeeding between ASD and controls and establish a temporal relation between ASD and breastfeeding are needed. Future studies should also evaluate interactions between ASD risk genes and breastfeeding. Autism Res 2019, 12: 816-829.Lay Summary: In this study, we compared breastfeeding practices between mothers of children with and without autism spectrum disorder (ASD). We found that the percentage of mothers who started breastfeeding was similar between the two groups, but mothers of children with ASD breastfed for a shorter amount of time compared to mothers of children without ASD. Future studies are needed to evaluate the reasons why the duration of breastfeeding was shorter for mothers of children with ASD compared to those without ASD.

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Section: Introductionmentioning

confidence: 99%

Association Between Breastfeeding Initiation and Duration and Autism Spectrum Disorder in Preschool Children Enrolled in the Study to Explore Early Development

et al. 2019

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“…The development of ASD is suggested to be related to abnormalities of the oxytocin-arginin-vasopressin system. Previous results suggest that OXT and arginine vasopressin (AVP) may play a role in the etiopathogenesis of ASD [20]. The effects of oxytocin on social cognition and behavior have recently attracted considerable attention and numerous papers have researched the possible role of oxytocin as therapeutic agent to treat ASD [21,22].…”

Section: Discussionmentioning

confidence: 99%

Laboratory Findings in Twins Suffering from Autism—Case Report

Dunjić¹,

Pejić²,

Filipović³

et al. 2019

JHS

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Autism refers a wide range of conditions and the most prominent are challenges with social skills, repetitive behaviors, speech disturbances. By now, it is known that there is no one type of autism, but there are many of them which are caused by genetic factors and environmental influences. Sometimes autism is called autism spectrum disorders which reflect the wide variation in challenges and strengths possessed by each person with autism (e.g., gastrointestinal disorders, seizures, sleep disturbances, attention deficit and hyperactivity disorders, anxiety etc.). Around one third of all people with autism remain nonverbal and have an intellectual disability. This condition can be detected as early as 18 months, but the most obvious signs tend to appear between 2 and 3 years of age. Only early intervention in those patients can improve outcomes. There are no many articles published regarding laboratory findings in autism patients. By performing holistic approach in patient healing, we also face autistic children in everyday practice. In this paper we represented case of twins suffering from autism. We found that both of them had elevation of free triiodothyronine, oxytocin, osteocalcin, and basophils. We found that vitamin D level in both twins was lower than recommended. Further research in this field is necessary to reveal whether these findings are causal factors for autism or are an effect of the disease.

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“…The rationale for oxytocin and some evidence from mixed findings of some clinical trials have been reviewed . Using a Shank3‐deficient rat model (which exhibited impaired long‐term social recognition memory and attention), oxytocin was shown to reverse some deficits of these rats .…”

Section: Future Directionsmentioning

confidence: 99%

“…89 The rationale for oxytocin and some evidence from mixed findings of some clinical trials have been reviewed. 90,91 Using a Shank3-deficient rat model (which exhibited impaired long-term social recognition memory and attention), oxytocin was shown to reverse some deficits of these rats. 92 The mechanism of this drug could be due to the effect of oxytocin on oxytocinergic (OXT) neurons in the OXT circuit whose disruption could lead to deficits in social behavior as indicated by studies on a developmental mutation zebrafish model with otpa(−/−) deficits.…”

Section: Potential Treatment or Preventive Strategies For Autismmentioning

confidence: 99%

Genetics and epigenetics of autism: A Review

Waye

Cheng

2017

Psychiatry Clin Neurosci

122

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Autism is a developmental disorder that starts before age 3 years, and children with autism have impairment in both social interaction and communication, and have restricted, repetitive, and stereotyped patterns of behavior, interests, and activities. There is a strong heritable component of autism and autism spectrum disorder (ASD) as studies have shown that parents who have a child with ASD have a 2-18% chance of having a second child with ASD. The prevalence of autism and ASD have been increasing during the last 3 decades and much research has been carried out to understand the etiology, so as to develop novel preventive and treatment strategies. This review aims at summarizing the latest research studies related to autism and ASD, focusing not only on the genetics but also some epigenetic findings of autism/ASD. Some promising areas of research using transgenic/knockout animals and some ideas related to potential novel treatment and prevention strategies will be discussed.

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The potential role of oxytocin and perinatal factors in the pathogenesis of autism spectrum disorders – review of the literature

Cited by 21 publications

References 37 publications

Association Between Breastfeeding Initiation and Duration and Autism Spectrum Disorder in Preschool Children Enrolled in the Study to Explore Early Development

Association Between Breastfeeding Initiation and Duration and Autism Spectrum Disorder in Preschool Children Enrolled in the Study to Explore Early Development

Laboratory Findings in Twins Suffering from Autism—Case Report

Genetics and epigenetics of autism: A Review

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