The potential role of RNA N6-methyladenosine in Cancer progression

Wang, Tianyi; Kong, Shan; Mei, Tao; Ju, Shaoqing

doi:10.1186/s12943-020-01204-7

Cited by 689 publications

(588 citation statements)

References 161 publications

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“…As aforementioned, m 6 A modification is a dynamic and reversible epigenetic change ( Zhang et al, 2020 ), which affects the stability and function of RNAs, thereby modulating the pathogenesis and progression of diseases ( Qin et al, 2020 ; Wang et al, 2020 ; Zhu et al, 2020 ). M 6 A modification has been identified in more than 7,000 human genes, and it preferentially occurred at the site of stop codons and long internal exons within the RRACH sequence (R = G or A; H = A, C, or U) ( Dominissini et al, 2012 ).…”

Section: Rna M 6 a Modificationmentioning

confidence: 99%

Multifaceted Functions and Novel Insight Into the Regulatory Role of RNA N6-Methyladenosine Modification in Musculoskeletal Disorders

Zhang

Liu

et al. 2020

Front. Cell Dev. Biol.

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RNA modifications have emerged as key regulators of transcript expression in diverse physiological and pathological processes. As one of the most prevalent types of RNA modifications, N 6 -methyladenosine (m 6 A) has become the highlight in modulation of various diseases through interfering RNA splicing, translation, nuclear export, and decay. In many cases, the detailed functions of m 6 A in cellular processes and diseases remain unclear. Notably, recent studies have determined the relationship between m 6 A modification and musculoskeletal disorders containing osteosarcoma, osteoarthritis, rheumatoid arthritis, osteoporosis, etc. Herein, this review comprehensively summarizes the recent advances of m 6 A modification in pathogenesis and progression of musculoskeletal diseases. Specifically, the underlying molecular mechanisms, detection technologies, regulatory functions, clinical implications, and future perspectives of m 6 A in musculoskeletal disorders are discussed, with the aim to provide a novel insight into their association.

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Section: Rna M 6 a Modificationmentioning

confidence: 99%

Multifaceted Functions and Novel Insight Into the Regulatory Role of RNA N6-Methyladenosine Modification in Musculoskeletal Disorders

Zhang

Liu

et al. 2020

Front. Cell Dev. Biol.

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“…RNA methylation plays an important role in many biological processes and is widely involved in human development and disease occurrence [49]. N6-methyladenosine (m6A) is a conserved internal modi cation of most eukaryotic nuclear RNA, which is closely related to the splicing , stability and translation e ciency of mRNA and noncoding RNA [28,50].With further studies, M6A can catalyse the M6A modi cation in the mRNA of oncogenes or tumor suppressor genes,and recognize the changes through molecular biological mechanism to regulate the expression of oncogene and tumor suppressor gene [51].The evidence showed that the change of m6A level was involved in the occurrence and development of tumor by affecting the expression of tumor-related genes BRD4, SOCS2 and EGFR [52].…”

Section: Discussionmentioning

confidence: 99%

The prognostic value of METTL3 in cancer patients: a meta-analysis

Pan

et al. 2020

Preprint

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Background: M6A methylation modification of RNA can regulate the development of tumor cells. METTL3 is one of the modified methyltransferases. A growing number of studies have shown that high expression of METTL3 may be associated with the unfavorable prognosis in cancer patients and may become a new biomarker. Therefore, this meta-analysis was used to evaluate the prognostic value of METTL3 in cancer patients through the available literature information.Methods: Relevant studies were retrieved from electronic literature databases including six English databases and three Chinese databases. Correlation analysis was conducted by Stata SE 15.1 and RevMan 5.3 software. We analyzed 11 eligible studies with a total of 1638 cancer patients in this meta-analysis. We took advantage of HRs and ORs with 95% confidence intervals to evaluate the prognostic value of METTL3 in tumors. Besides,the article was qualified by MOOSE check lists and PRISMA Checklist. Results: The results of the meta-analysis indicated that high expression of METTL3 was associated with low overall survival (OS) (HR=2.67, 95%CI:2.19-3.25, P<0.00001) and disease-free survival (DFS) (HR=2.23, 95%CI:1.60-3.11, P<0.00001) in various cancers.Stratified analysis of cancer types showed that over expressed METTL3 was related to poor prognosis in digestive system cancer patients, including CRC(HR=2.29, 95%CI:1.50-3.49，P=0.0001) ,GC(HR=2.96，95%CI:2.13-4.12，P＜0.00001)，and liver cancer（HR=2.70，95%CI:1.88-3.88，P＜0.00001). Meanwhile, the elevated METTL3 expression also affected the lymph node metastasis (OR=3.40，95%CI=1.58-7.33，p=0.002) ，vascular invasion (OR=2.04，95%CI=1.06-3.95，p=0.03) and the tumors progression (III/IV vs. I/II: OR = 3.72, 95% CI: 1.94 - 7.13, P < 0.0001).Conclusion: The existing analysis indicates that METTL3 is associated with low OS and DFS in cancer patients and may serve as a biomarker to assess prognostic value.

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“…Inserting information beyond the information carried by their base sequences to gene transcripts, altering the charge of RNA bases and their matching properties, differential folding of RNAs, and the formation of a regulatory protein-RNA interaction recognition element are classical transcriptome modification processes. Therefore, these modifications are involved in the whole process of RNA metabolism, regulating the fine expression patterns of genes and, ultimately, affecting the biological behaviour of cells [11,12].…”

Section: Origin Of M6a Modificationmentioning

confidence: 99%

m6A modification in RNA: biogenesis, functions and roles in gliomas

Zhang

Geng

et al. 2020

J Exp Clin Cancer Res

120

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The chemical modification of RNA is a newly discovered epigenetic regulation mechanism in cells and plays a crucial role in a variety of biological processes. N6-methyladenine (m6A) mRNA modification is the most abundant form of posttranscriptional RNA modification in eukaryotes. Through the development of m6A RNA sequencing, the relevant molecular mechanism of m6A modification has gradually been revealed. It has been found that the effect of m6A modification on RNA metabolism involves processing, nuclear export, translation and even decay. As the most common malignant tumour of the central nervous system, gliomas (especially glioblastoma) have a very poor prognosis, and treatment efficacy is not ideal even with the application of high-intensity treatment measures of surgery combined with chemoradiotherapy. Exploring the origin and development mechanisms of tumour cells from the perspective of tumour biogenesis has always been a hotspot in the field of glioma research. Emerging evidence suggests that m6A modification can play a key role in gliomas through a variety of mechanisms, providing more possibilities for early diagnosis and targeted therapy of gliomas. The aim of the present review is to focus on the research progress regarding the association between m6A modification and gliomas. And to provide a theoretical basis according to the currently available literature for further exploring this association. This review may provide new insights for the molecular mechanism, early diagnosis, histologic grading, targeted therapy and prognostic evaluation of gliomas.

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The potential role of RNA N6-methyladenosine in Cancer progression

Cited by 689 publications

References 161 publications

Multifaceted Functions and Novel Insight Into the Regulatory Role of RNA N6-Methyladenosine Modification in Musculoskeletal Disorders

Multifaceted Functions and Novel Insight Into the Regulatory Role of RNA N6-Methyladenosine Modification in Musculoskeletal Disorders

The prognostic value of METTL3 in cancer patients: a meta-analysis

m6A modification in RNA: biogenesis, functions and roles in gliomas

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