The Predictive Ability of Triglycerides and Waist (Hypertriglyceridemic Waist) in Assessing Metabolic Triad Change in Obese Children and Adolescents

Hobkirk, James; King, Rhodri; Pemberton, Philip A.; Smith, Alwyn; Barth, Julian H.; Harman, Nicola; Davies, Ian G.; Carroll, Sean

doi:10.1089/met.2012.0152

Cited by 13 publications

(18 citation statements)

References 25 publications

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“…In this cross‐sectional study, we used the HTWP as a proxy measure of visceral adiposity to examine the cardiometabolic risk profiles in groups of normal weight and overweight/obese youth stratified by BMI. Near identical findings were evident when comparisons were made between those with and without the HTWP (Table ) and confirms the findings of others suggesting that the HTWP may serve as a useful diagnostic tool . Findings from http://onlinelibrary.wiley.com/doi/10.1111/ijpo.12061/suppinfo suggests that the HTWP may confer an improved discriminatory power when compared with WC and BMI for identifying individuals with elevated cardiometabolic risk profiles.…”

Section: Discussionsupporting

confidence: 83%

“…Findings of this study and previous investigations suggest that the HTWP is a convenient method which may serve as an effective tool for initial screening. Since measurements of WC and fasting TG are inexpensive and readily available within a clinical setting, further prolonged prospective study is encouraged to determine whether the measurement of this phenotype could improve the ability of practitioners to identify at‐risk individuals.…”

Section: Discussionsupporting

confidence: 58%

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Utility of the hypertriglyceridemic waist phenotype in the cardiometabolic risk assessment of youth stratified by body mass index

Buchan

Boddy

et al. 2015

Pediatric Obesity

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Abbreviations: BMI-Body Mass Index, WC-waist circumference; CRF-cardiorespiratory fitness; HTWP-hypertriglyceridemic waist phenotype; HDL-c-high density lipoprotein cholesterol; TC-total cholesterol; CRP-C-reactive protein; TG-triglycerides; HOMA-IR-the homeostatic model assessment of insulin resistance; SES-socioeconomic status. What is already known about this subject  Despite the clear relationship between BMI and the comorbidities associated with excess body fatness, the use of BMI is not without its limitations since by its very definition, BMI cannot distinguish between fat and fat-free mass  The presence of fasting hypertriglyceridemia alongside abdominal obesity may provide a useful indicator of visceral adiposity  The hypertriglyceridemic waist phenotype is a simple and inexpensive screening tool to identify adults at increased risk of cardiovascular disease and diabetes. What this study adds  The HTWP may confer an improved discriminatory power when compared to WC and BMI for identifying individuals with elevated cardiometabolic risk profiles.  The measurement of the hypertriglyceridemic waist phenotype appears to distinguish high risk viscerally obese individuals of the same weight status who may be more susceptible to related metabolic complications.  The addition of fasting triglycerides to waist circumference in order to identify the hypertriglyceridemic waist phenotype is a convenient and cost-effective means to identify those at greatest cardiometabolic risk, regardless of weight status. 3 Abstract: Background: It is unclear whether the Hypertriglyceridemic Waist Phenotype can be used to identify those at

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Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 58%

Utility of the hypertriglyceridemic waist phenotype in the cardiometabolic risk assessment of youth stratified by body mass index

Buchan

Boddy

et al. 2015

Pediatric Obesity

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“…Furthermore, waist circumference -which points to visceral obesity [23], was positively correlated with serum tryptase. Obesity is accompanied by adipocyte death and accumulation of macrophages and mast cells in expanding adipose tissues.…”

Section: Discussionmentioning

confidence: 94%

“…Central obesity has been associated with the risk of cardiovascular and metabolic disease in children and the most important index of central obesity is waist circumference [23].…”

Section: Discussionmentioning

confidence: 99%

Is Serum Tryptase a Valuable Marker for Obesity-Bronchial Asthma Interrelationship in Children?

Ta¹,

Kamel²,

Al-Aziz³

et al. 2017

Open J Trauma

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Background: Asthma among obese represents a unique phenotype. Mast cells are more abundant in obese. Serum tryptase (ST) is a marker of mast cell numbers or activity. Since obesity and asthma have been linked in epidemiological studies, a possible higher mast cell activity in obesity could be a factor between the two conditions. This study was to investigate ST and its potential association between obesity and childhood asthma.Methods: Study recruited 60 asthmatic children, their age ranged from 5-16 years. They were divided according to BMI centile to 30 obese and 30 non-obese asthmatics. Thirty healthy non-asthmatic, nonatopic and non-obese children; were included as a healthy control. Serum tryptase, atopy (skin prick test reactivity) and spirometry were assessed.Results: Frequency of atopy and positive skin prick test signifi cantly increased among obese more than non-obese asthmatics (P<0.05, OR = 1.96, 95% CI = 1.27-3.24). FEV1% of predicted mean levels were lower among obese than non-obese asthmatics (p<0.05). ST was signifi cantly higher in asthmatics than in controls with a mean ±SD of 53.3±13.78 ng/ml and 10.06±4.39 ng/ml respectively. ST was higher in obese than non-obese asthmatics with a mean ±SD of 71.73±19.17 ng/ml and 34.5±8.68 ng/ml respectively (P<0.05). There was a negative correlation between ST and FEV1 % of predicted and positive correlations between ST and age, BMI, and waist circumference among asthmatics. Conclusion:Mast cells play a role in both obesity and asthma, serum tryptase, being a marker of mast cell activation, could represent a link between them.

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“…The hypertriglyceridemic waist phenotype (enlarged waist and elevated triglycerides, EWET), defined as simultaneous presence of increased waist circumference and elevated triglycerides, seems to more accurately identify individuals who are at risk, compared with isolated measurements of waist circumference or serum triglycerides, 7 and can be applied in clinical practice. In addition to the strong association of the hypertriglyceridemic waist phenotype with the atherogenic triad, 8,9 it is related to increased visceral adipose tissue, 10 worse cardiometabolic profile (both in the general population [11][12][13] and in individuals who are at risk 14,15 or who present cardiovascular disease 16 ), higher incidence of coronary artery disease and cardiovascular mortality. 17 Low high-density lipoprotein-cholesterol (HDL-c) levels are negatively associated with cardiovascular events in individuals with cardiovascular diseases.…”

Section: Introductionmentioning

confidence: 99%

Enlarged waist combined with elevated triglycerides (hypertriglyceridemic waist phenotype) and HDL-cholesterol in patients with heart failure

et al. 2017

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CONTEXT AND OBJECTIVE: The association of serum triglycerides plus waist circumference seems to be a good marker of cardiovascular risk and has been named the “hypertriglyceridemic waist” phenotype. The aim of our study was to investigate the association between the hypertriglyceridemic waist phenotype and HDL-cholesterol among patients with heart failure. DESIGN AND SETTING: Cross-sectional study in a tertiary-level hospital in southern Brazil. METHODS: We included patients with heart failure aged > 40 years. Anthropometric assessment (weight, height, waist and hip circumferences) was performed; body mass index (BMI) and waist-hip ratio were calculated and lipid measurements (serum total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides) were collected. In men and women, respectively, waist circumference ≥ 94 cm and ≥ 80 cm, and triglycerides ≥ 150 mg/dl were considered abnormal and were used to identify the hypertriglyceridemic waist phenotype. Analyses of covariance were used to evaluate possible associations between levels of HDL-cholesterol and the hypertriglyceridemic waist phenotype, according to sex. RESULTS: 112 participants were included, of whom 62.5% were men. The mean age was 61.8 ± 12.3 years and the mean ejection fraction was 40.1 ± 14.7%. Men and woman presented mean HDL-cholesterol of 40.5 ± 14.6 and 40.9 ± 12.7 mg/dl, respectively. The prevalence of the hypertriglyceridemic waist phenotype was 25%. There was a significant difference in mean HDL-cholesterol between men with and without the hypertriglyceridemic waist phenotype (32.8 ± 14.2 versus 42.1 ± 13.7 mg/dl respectively; P = 0.04), even after adjustment for age, body mass index, type 2 diabetes mellitus, use of statins and heart failure etiology. CONCLUSIONS: The hypertriglyceridemic waist phenotype is significantly associated with lower HDL-cholesterol levels in men with heart failure.

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The Predictive Ability of Triglycerides and Waist (Hypertriglyceridemic Waist) in Assessing Metabolic Triad Change in Obese Children and Adolescents

Cited by 13 publications

References 25 publications

Utility of the hypertriglyceridemic waist phenotype in the cardiometabolic risk assessment of youth stratified by body mass index

Utility of the hypertriglyceridemic waist phenotype in the cardiometabolic risk assessment of youth stratified by body mass index

Is Serum Tryptase a Valuable Marker for Obesity-Bronchial Asthma Interrelationship in Children?

Enlarged waist combined with elevated triglycerides (hypertriglyceridemic waist phenotype) and HDL-cholesterol in patients with heart failure

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