The predictive role of CA-125 in the management of tubo-ovarian abscess. A retrospective study

Herzberg, Shmuel; Dior, Uri; Shushan, Asher; Gilad, Ronit; Benshushan, Abraham; Rottenstreich, Amihai

doi:10.1016/j.ejogrb.2019.05.004

Cited by 17 publications

(15 citation statements)

References 32 publications

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“…The association of in ammatory markers with TOA in the presence or absence of endometriosis remains unclear. Several studies have shown that platelets are involved in regulating the in ammatory response and are elevated among TOA patients [15][16][17]. In the presence of in ammation, platelets are activated and release a large number of in ammatory and mitotic substances.…”

Section: Discussionmentioning

confidence: 99%

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Clinical characteristics, treatment status and complications in women with tube ovarian abscess and endometriosis: a retrospective study

Zhao

Chang

et al. 2020

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Background: The aim of our present study was to investigate the clinical characteristics, treatment status and complications in women with endometriosis and tube ovarian abscess (TOA) to determine the possible association between TOA and endometriosis.Methods: Medical records were used to analyze the clinical characteristics, treatment and complications. Twenty women who were diagnosed with TOA with endometriosis were compared with 93 women diagnosed as having TOA without endometriosis between January, 2008 and December, 2018. Statistical analysis was performed using SPSS Version 20.Results: In this study, TOA patients with endometriosis were significantly more likely to have a lower age range (20–39years) than the non-endometriosis group (11/20 (55.0%) vs 27/93 (29.0%), p=0.036). In addition, TOA patients with endometriosis were associated with a significantly lower rate of parity (11/20 (55.0%) vs 75/93 (80.6%), p=0.021), higher rates of infertility (8/20(40%) vs 0/93(0%), p=0.000) and a significantly lower incidence of elevated blood platelet counts (5/20 (25%) vs 43/93 (53.8%), p = 0.026). Furthermore, women with endometriosis had greater blood loss (347±445.77 vs 204.67±289.46, p= 0.014) and an increased complication rate (3/20(15%) vs 0/93(0%), p = 0.000). Among the 3 patients who had complications in the endometriosis group, 2 patients had septic shock and 1 patient had intestinal obstruction. And 1 case who had septic shock followed by IVF treatment. There was no significance difference on other factors.Conclusions: The present study indicated that endometriosis did not increase the difficulty and time of treatment in patients with TOA, but increased bleeding during surgery and serious complications. It is suggested that doctors should pay more attention to postoperative treatment and nursing in women with TOA and endometriosis, especially those who have a history of recent infertility treatment and related procedures.

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Section: Discussionmentioning

confidence: 99%

“…Several studies have found that CA-125 serum levels were related to the occurrence of TOA and have a prognostic role during conservative parenteral antibiotic therapy [15,23]. However, few studies have examined the difference in CA-125 levels in TOA patients based on endometriosis.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics, treatment status and complications in women with tube ovarian abscess and endometriosis: a retrospective study

Zhao

Chang

et al. 2020

Preprint

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“…In routine clinical practice, CA125 has been investigated extensively as a biomarker of EM. Several studies have found that CA-125 serum levels were related to the occurrence of TOA and have a prognostic role during conservative parenteral antibiotic therapy [25,26]. Whether CA125 can be used as the predictive marker for the development of TOA in EM patients.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics, treatment status and complications in women with tube ovarian abscess and endometriosis: a retrospective study

Zhao

Chang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: The aim of our present study was to investigate the clinical characteristics, treatment status and complications in women with endometriosis (EM) and tube ovarian abscess (TOA) to determine the possible association between TOA and EM.Methods: Medical records were used to analyze the clinical characteristics, treatment and complications. Twenty women who were diagnosed with TOA with EM were compared with 93 women diagnosed as having TOA without EM between January, 2008 and December, 2018. Results: In this study, TOA patients with EM were significantly more likely to have a lower age range (20–39years) than the non-EM group (11/20 (55.0%) vs 27/93 (29.0%)). In addition, TOA patients with EM were associated with a significantly lower rate of parity (11/20 (55.0%) vs 75/93 (80.6%),), higher rates of infertility (8/20(40%) vs 0/93(0%),) and a significantly lower incidence of elevated blood platelet counts (5/20 (25%) vs 43/93 (53.8%)). Furthermore, women with EM had greater blood loss (347±445.77 vs 204.67±289.46) and an increased complication rate (3/20(15%) vs 0/93(0%)). Among the 3 patients who had complications in the EM group, 2 patients had septic shock and 1 patient had intestinal obstruction. And 1 case who had septic shock followed by IVF treatment. There was no significance difference on other factors.Conclusions: The present study indicated that EM did not increase the difficulty and time of treatment in patients with TOA, but increased bleeding during surgery and serious complications. It is suggested that doctors should pay more attention to postoperative treatment and nursing in women with TOA and EM, especially those who have a history of recent infertility treatment and related procedures.

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“…Previous studies have identified predisposing risk factors for PID, such as multiple sexual partners, sexually transmitted infection, young age and African American ethnicity. Whereas barrier contraception methods seem to be protective [4,5] and the first line of treatment consists of antibiotics with a high success rate [6], newer studies are trying to define markers associated with the failure of conservative treatment in order to adapt therapy in the acutest way [7].…”

Section: Introductionmentioning

confidence: 99%

Risk factors for recurrent Pelvic Inflammatory Disease

Safrai

Rottenstreich

Shushan

et al. 2020

European Journal of Obstetrics & Gynecology and Reproductiv

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The predictive role of CA-125 in the management of tubo-ovarian abscess. A retrospective study

Cited by 17 publications

References 32 publications

Clinical characteristics, treatment status and complications in women with tube ovarian abscess and endometriosis: a retrospective study

Clinical characteristics, treatment status and complications in women with tube ovarian abscess and endometriosis: a retrospective study

Clinical characteristics, treatment status and complications in women with tube ovarian abscess and endometriosis: a retrospective study

Risk factors for recurrent Pelvic Inflammatory Disease

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